Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 11/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6988058 | 0.91 | CYP11B1 (0.53) | NAMPTRAB9ANPC1ALDH1A1SLC2A1 | |
| SCHEMBL6615774 | 0.76 | NAMPT (0.47) | NAMPTRAB9ANPC1SMN1; SMN2TRPV1 | |
| SCHEMBL6989605 | 0.76 | ABCC9 (0.53) | NAMPTRAB9ANPC1ALDH1A1SMN1; SMN2 | |
| SCHEMBL6615371 | 0.72 | ABCC9 (0.64) | NAMPTRAB9ANPC1ALDH1A1SMN1; SMN2 | |
| SCHEMBL6612614 | 0.72 | CYP11B1 (0.54) | NAMPTRAB9ANPC1SMN1; SMN2LMNA | |
| SCHEMBL6612270 | 0.71 | CYP11B1 (0.53) | NAMPTRAB9ANPC1SMN1; SMN2LMNA | |
| SCHEMBL6612030 | 0.71 | NAMPT (0.62) | NAMPTRAB9ANPC1ALDH1A1SMN1; SMN2 | |
| SCHEMBL6643209 | 0.71 | CYP11B1 (0.58) | NAMPTRAB9ANPC1SMN1; SMN2LMNA | |
| SCHEMBL6614923 | 0.70 | NAMPT (0.58) | NAMPTRAB9ANPC1ALDH1A1SMN1; SMN2 | |
| SCHEMBL7736678 | 0.70 | CYP11B1 (0.51) | NAMPTRAB9ANPC1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1358160-A1 | AMINAL DIONES AS POTASSIUM CHANNEL OPENERS | Abbott Laboratories (US) | 2003-11-05 | — | — | EP | disclosed |
| WO-2002062761-A1 | AMINAL DIONES AS POTASSIUM CHANNEL OPENERS | ABBOTT LABORATORIES (US) | 2002-08-15 | — | — | WO | disclosed |