SCHEMBL6989627

SCHEMBL6989627

CNC(c1ccncc1)c1ccc2c(c1)NC(=O)C(C)O2

nearest known ligand 0.47

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
PARP1 P09874 8/20 0.45
PDE3B Q13370 3/20 0.43
PDE3A Q14432 3/20 0.43
SMYD3 Q9H7B4 3/20 0.40
MAOB P27338 1/20 0.38
ADORA2A P29274 1/20 0.38
CYP3A4 P08684 1/20 0.36
CYP2C19 P33261 1/20 0.36
KDR P35968 1/20 0.35
USP2 O75604 1/20 0.33
GAA P10253 1/20 0.33
MAPT P10636 1/20 0.32
TSHR P16473 1/20 0.32
HSD17B10 Q99714 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6992024 0.86 PARP1 (0.44) PARP1PDE3BPDE3ASMYD3MAOB
SCHEMBL6997052 0.81 PARP1 (0.43) PARP1PDE3BPDE3ASMYD3MAOB
SCHEMBL6999246 0.81 PARP1 (0.48) PARP1PDE3BPDE3ASMYD3MAOB
SCHEMBL6998255 0.81 PARP1 (0.45) PARP1PDE3BPDE3ASMYD3MAOB
SCHEMBL6998103 0.77 PARP1 (0.46) PARP1PDE3BPDE3ASMYD3MAOB
SCHEMBL16804878 0.76 PARP1 (0.57) PARP1PDE3BPDE3ASMYD3MAOB
SCHEMBL19966801 0.76 PARP1 (0.57) PARP1PDE3BPDE3ASMYD3MAOB
SCHEMBL6996963 0.72 CYP3A4 (0.33) CYP3A4CYP2C19
SCHEMBL6989623 0.72 PARP1 (0.78) PARP1PDE3BPDE3ASMYD3MAOB
SCHEMBL7711106 0.72 PDE3B (0.38) PARP1PDE3BPDE3ASMYD3KDR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1015437-B1 BENZOXAZINE AND BENZOTHIAZINE DERIVATIVES AND THEIR USE IN PHARMACEUTICALS SCHERING AG (DE) 2003-12-03 EP disclosed
US-6365736-B1 TREATMENT OF NERVOUS SYSTEM DISORDERS, CARDIOVASCULAR DISORDERS AND FOR ACTIVITY AS NO-SYNTHASES (NOS) INHIBITORS. SCHERING AKTIENGESELLSCHAFT (DE) 2002-04-02 US disclosed