SCHEMBL6992024

SCHEMBL6992024

CNC(c1cccnc1)c1ccc2c(c1)NC(=O)C(C)O2

nearest known ligand 0.44

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
PARP1 P09874 6/20 0.44
PDE3B Q13370 3/20 0.40
PDE3A Q14432 3/20 0.40
SMYD3 Q9H7B4 3/20 0.40
MAPT P10636 3/20 0.40
TSHR P16473 2/20 0.40
HSD17B10 Q99714 2/20 0.40
MAOB P27338 1/20 0.38
ADORA2A P29274 1/20 0.38
KDR P35968 1/20 0.35
POLB P06746 1/20 0.35
GAA P10253 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6989627 0.86 PARP1 (0.45) PARP1PDE3BPDE3ASMYD3MAPT
SCHEMBL6999246 0.80 PARP1 (0.48) PARP1PDE3BPDE3ASMYD3MAOB
SCHEMBL6997052 0.78 PARP1 (0.43) PARP1PDE3BPDE3ASMYD3MAOB
SCHEMBL6998255 0.77 PARP1 (0.45) PARP1PDE3BPDE3ASMYD3MAOB
SCHEMBL6992569 0.76 PDE3B (0.54) PARP1PDE3BPDE3AMAPTTSHR
SCHEMBL6998103 0.75 PARP1 (0.46) PARP1PDE3BPDE3ASMYD3MAOB
SCHEMBL7708177 0.74 MAPT (0.36) PARP1PDE3BPDE3ASMYD3MAPT
SCHEMBL6991325 0.74 SMYD3 (0.36) PARP1PDE3BPDE3ASMYD3MAPT
SCHEMBL16804878 0.73 PARP1 (0.57) PARP1PDE3BPDE3ASMYD3MAPT
SCHEMBL19966801 0.73 PARP1 (0.57) PARP1PDE3BPDE3ASMYD3MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1015437-B1 BENZOXAZINE AND BENZOTHIAZINE DERIVATIVES AND THEIR USE IN PHARMACEUTICALS SCHERING AG (DE) 2003-12-03 EP disclosed
US-6365736-B1 TREATMENT OF NERVOUS SYSTEM DISORDERS, CARDIOVASCULAR DISORDERS AND FOR ACTIVITY AS NO-SYNTHASES (NOS) INHIBITORS. SCHERING AKTIENGESELLSCHAFT (DE) 2002-04-02 US disclosed