Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | QPCT | Q16769 | 10/20 | 0.46 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.45 |
| ▸ | IDO1 | P14902 | 1/20 | 0.45 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14416041 | 0.82 | QPCT (0.50) | QPCT | |
| SCHEMBL6496747 | 0.81 | CYP11B1 (0.63) | QPCTCYP11B1CYP11B2IDO1CYP19A1 | |
| SCHEMBL14416032 | 0.79 | MEN1 (0.47) | QPCTIDO1 | |
| SCHEMBL2780498 | 0.79 | HTT (0.47) | HTTCYP11B1CYP11B2IDO1ALDH1A1 | |
| SCHEMBL1501884 | 0.77 | CYP11B1 (0.70) | HTTCYP11B1CYP11B2IDO1ADORA2A | |
| SCHEMBL4483111 | 0.77 | TSHR (0.42) | TSHRQPCTCYP11B1CYP11B2IDO1 | |
| SCHEMBL6599807 | 0.76 | CYP11B1 (0.55) | HTTCYP11B1CYP11B2IDO1ALDH1A1 | |
| SCHEMBL8542377 | 0.75 | HRH3 (0.53) | — | |
| SCHEMBL6994652 | 0.75 | QPCT (0.40) | TSHRQPCTCYP11B1CYP11B2CYP19A1 | |
| SCHEMBL14415972 | 0.75 | CYP11B1 (0.50) | HTTCYP11B1CYP11B2IDO1ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0588858-B1 | IMIDAZO 2,1-b] 3]BENZAZEPINE DERIVATIVES, COMPOSITIONS AND METHOD OF USE | JANSSEN PHARMACEUTICA NV (BE) | 2003-09-17 | — | — | EP | disclosed |
| US-5468743-A | Imidazo[2,1-b]benzazepine derivatives, compositions and method of use | JANSSEN PHARMACEUTICA N.V. (BE) | 1995-11-21 | — | — | US | disclosed |
| EP-0588858-A1 | IMIDAZO 2,1-b] 3]BENZAZEPINE DERIVATIVES, COMPOSITIONS AND METHOD OF USE | JANSSEN PHARMACEUTICA N.V. (BE) | 1994-03-30 | — | — | EP | disclosed |
| WO-1992022551-A1 | IMIDAZO[2,1-b][3]BENZAZEPINE DERIVATIVES, COMPOSITIONS AND METHOD OF USE | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-12-23 | — | — | WO | disclosed |
| EP-0518435-A1 | Imidazo[2,1-b][3]benzazepine derivatives, compositions and method of use | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-12-16 | — | — | EP | disclosed |