Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 12/20 | 0.63 |
| ▸ | CYP11B2 | P19099 | 12/20 | 0.63 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.63 |
| ▸ | IDO1 | P14902 | 2/20 | 0.61 |
| ▸ | HPGDS | O60760 | 1/20 | 0.51 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.50 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.47 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.47 |
| ▸ | TNF | P01375 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.43 |
| ▸ | QPCT | Q16769 | 1/20 | 0.43 |
| ▸ | CYP4Z1 | Q86W10 | 1/20 | 0.43 |
| ▸ | QPCTL | Q9NXS2 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15075172 | 0.85 | CYP11B1 (0.68) | CYP11B1CYP11B2CYP19A1IDO1MAPT | |
| SCHEMBL4833123 | 0.81 | CYP11B1 (0.64) | CYP11B1CYP11B2CYP19A1IDO1 | |
| SCHEMBL6989844 | 0.81 | TSHR (0.48) | CYP11B1CYP11B2CYP19A1IDO1QPCT | |
| SCHEMBL8652818 | 0.81 | CYP11B1 (0.64) | CYP11B1CYP11B2CYP19A1IDO1 | |
| SCHEMBL4480052 | 0.80 | CYP11B1 (0.51) | CYP11B1CYP11B2CYP19A1IDO1 | |
| SCHEMBL9413343 | 0.78 | CYP11B1 (0.62) | CYP11B1CYP11B2CYP19A1IDO1HPGDS | |
| SCHEMBL27984850 | 0.78 | CYP11B1 (0.62) | CYP11B1CYP11B2IDO1HPGDSP2RX7 | |
| SCHEMBL15458790 | 0.78 | CYP11B1 (0.57) | CYP11B1CYP11B2CYP19A1IDO1HPGDS | |
| SCHEMBL1812632 | 0.78 | CYP11B1 (0.53) | CYP11B1CYP11B2IDO1HPGDSP2RX7 | |
| SCHEMBL3822425 | 0.78 | CYP11B1 (1.00) | CYP11B1CYP11B2CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005016883-A2 | ACRYLAMIDE DERIVATIVES AS VLA-1 INTEGRIN ANTAGONISTS AND USES THEREOF | ICOS CORPORATION (US) | 2005-02-24 | — | — | WO | claimed |
| US-20220214276-A1 | SKIN SENSITIZATION MEASURING REAGENT, METHOD FOR MEASURING SKIN SENSITIZATION, AND COMPOUND | FUJIFILM CORPORATION (JP) | 2022-07-07 | — | — | US | disclosed |
| CN-114230522-A | Imidazole-2-carboxylic acid metal beta-lactamase inhibitor and preparation method and application thereof | 四川大学 | 2022-03-25 | — | — | CN | disclosed |
| CN-109069461-A | The treatment method of illness relevant to marrow source property inhibition cell | 洛克菲勒大学 | 2018-12-21 | — | — | CN | disclosed |
| US-9212348-B2 | Method for producing hematopoietic stem cells using pyrazole compounds | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2015-12-15 | — | — | US | disclosed |
| US-8921388-B2 | Dihydroxypyrimidine carbonic acid derivatives and their use in the treatment, amelioration or prevention of a viral disease | EUROPEAN MOLECULAR BIOLOGY LABORATORY (DE) | 2014-12-30 | — | — | US | disclosed |
| US-20140057353-A1 | METHOD FOR PRODUCING HEMATOPOIETIC STEM CELLS USING PYRAZOLE COMPOUNDS | REPROCELL INCORPORATED (JP) | 2014-02-27 | — | — | US | disclosed |
| US-8658686-B2 | Pyrazole compounds having therapeutic effect on multiple myeloma | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2014-02-25 | — | — | US | disclosed |
| US-20140038990-A1 | Dihydroxypyrimidine carbonic acid derivatives and their use in the treatment, amelioration or prevention of a viral disease | SAVIRA PHARMACEUTICALS GMBH (AT) | 2014-02-06 | — | — | US | disclosed |
| US-20130253204-A1 | PYRAZOLE COMPOUNDS HAVING THERAPEUTIC EFFECT ON MULTIPLE MYELOMA | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2013-09-26 | — | — | US | disclosed |
| CN-101107246-B | Anti-trypanosomiasis agent | FUJI PHOTO FILM CO LTD | 2011-04-20 | — | — | CN | disclosed |
| US-20090176775-A1 | DERIVATIVES OF UREAS OF PIPERIDINE OR PYRROLIDINE, THEIR PREPARATION AND THEIR THERAPEUTICAL USE | SANOFI-AVENTIS (FR) | 2009-07-09 | — | — | US | disclosed |
| US-20090176775-A1 | DERIVATIVES OF UREAS OF PIPERIDINE OR PYRROLIDINE, THEIR PREPARATION AND THEIR THERAPEUTICAL USE | SANOFI-AVENTIS (FR) | 2009-07-09 | — | — | US | disclosed |
| US-20080269250-A1 | Pyrrolidine and Piperidine Acetylene Derivatives for Use as Mglur5 Antagonists | NOVARTIS AG (CH) | 2008-10-30 | — | — | US | disclosed |
| US-20080269250-A1 | Pyrrolidine and Piperidine Acetylene Derivatives for Use as Mglur5 Antagonists | NOVARTIS AG (CH) | 2008-10-30 | — | — | US | disclosed |
| CN-101107246-A | Anti-trypanosomiasis agent | JAPAN SCIENCE & TECH AGENCY (JP) | 2008-01-16 | — | — | CN | disclosed |
| CN-101031295-A | Pharmaceutical composition for preventing or treating protozoan infection | JAPAN SCIENCE & TECH AGENCY (JP) | 2007-09-05 | — | — | CN | disclosed |
| WO-2006089700-A1 | PYRROLIDINE AND PIPERIDINE ACETYLENE DERIVATIVES FOR USE AS MGLUR5 ANTAGONISTS | NOVARTIS AG (CH) | 2006-08-31 | — | — | WO | disclosed |
| WO-2005016883-A2 | ACRYLAMIDE DERIVATIVES AS VLA-1 INTEGRIN ANTAGONISTS AND USES THEREOF | ICOS CORPORATION (US) | 2005-02-24 | — | — | WO | disclosed |
| WO-1993013077-A1 | ANGIOTENSIN II RECEPTOR ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 1993-07-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080269250-A1 | Pyrrolidine and Piperidine Acetylene Derivatives for Use as Mglur5 Antagonists | GRM5, GRIK5, GRM1 | CYP11B1 2973/4885CYP11B2 2584/4885CYP19A1 3294/4885 |
| US-20140038990-A1 | Dihydroxypyrimidine carbonic acid derivatives and their use in the treatment, amelioration or prevention of a viral disease | DPYD, DHODH, ALAD | CYP11B1 118/4885CYP11B2 102/4885CYP19A1 1134/4885 |
| US-20090176775-A1 | DERIVATIVES OF UREAS OF PIPERIDINE OR PYRROLIDINE, THEIR PREPARATION AND THEIR THERAPEUTICAL USE | HSD11B1, HSD3B1, ADH1C | CYP11B1 11/4885CYP11B2 29/4885CYP19A1 62/4885 |
| US-20130253204-A1 | PYRAZOLE COMPOUNDS HAVING THERAPEUTIC EFFECT ON MULTIPLE MYELOMA | MCL1, BCL6, RTN3 | CYP11B1 2212/4885CYP11B2 3246/4885CYP19A1 4546/4885 |
| US-20140057353-A1 | METHOD FOR PRODUCING HEMATOPOIETIC STEM CELLS USING PYRAZOLE COMPOUNDS | HCLS1, RUNX1, HPRT1 | CYP11B1 227/4885CYP11B2 455/4885CYP19A1 3510/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.