Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.49 |
| ▸ | IDO1 | P14902 | 5/20 | 0.45 |
| ▸ | GPR183 | P32249 | 1/20 | 0.44 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | FLT1 | P17948 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | F2 | P00734 | 1/20 | 0.43 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | RHEB | Q15382 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | DAO | P14920 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8802664 | 0.91 | LOXL2 (0.57) | LOXL2IDO1SIRT1EGFRFLT1 | |
| SCHEMBL6826452 | 0.87 | LOXL2 (0.64) | LOXL2SIRT1EGFRF2PCSK9 | |
| SCHEMBL28178529 | 0.84 | F2 (0.58) | IDO1EGFRF2CYP19A1SMN1; SMN2 | |
| SCHEMBL865591 | 0.83 | CYP19A1 (0.50) | LOXL2IDO1F2CYP19A1FFAR1 | |
| SCHEMBL9530334 | 0.81 | MEN1 (0.49) | LOXL2SIRT1EGFRKDRF2 | |
| SCHEMBL6994727 | 0.81 | LOXL2 (0.57) | LOXL2SIRT1F2PCSK9RHEB | |
| SCHEMBL6984195 | 0.81 | LOXL2 (0.49) | LOXL2SIRT1F2PCSK9RHEB | |
| SCHEMBL15363374 | 0.80 | PDE3B (0.45) | GPR183DAO | |
| SCHEMBL6619148 | 0.79 | PCSK9 (0.57) | LOXL2F2PCSK9DAO | |
| SCHEMBL6989299 | 0.78 | LOXL2 (0.57) | LOXL2IDO1SIRT1F2PCSK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1322646-A1 | 2-(1H-INDOL-3-YL)-2-OXO-ACETIC ACID AMIDES WITH ANTITUMOR ACTIVITY | Novuspharma S.p.A. (IT) | 2003-07-02 | — | — | EP | disclosed |
| WO-2002008225-A1 | 2-(1H-INDOL-3-YL)-2-OXO-ACETIC ACID AMIDES WITH ANTITUMOR ACTIVITY | NOVUSPHARMA S.P.A. (IT) | 2002-01-31 | — | — | WO | disclosed |