Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.57 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | PCSK9 | Q8NBP7 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | DAO | P14920 | 1/20 | 0.44 |
| ▸ | IDO1 | P14902 | 2/20 | 0.43 |
| ▸ | F2 | P00734 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 2/20 | 0.42 |
| ▸ | TDO2 | P48775 | 1/20 | 0.42 |
| ▸ | PYGL | P06737 | 1/20 | 0.42 |
| ▸ | PYGM | P11217 | 1/20 | 0.42 |
| ▸ | CYP51A1 | Q16850 | 1/20 | 0.42 |
| ▸ | GUSB | P08236 | 1/20 | 0.41 |
| ▸ | IDH1 | O75874 | 1/20 | 0.41 |
| ▸ | F7 | P08709 | 1/20 | 0.41 |
| ▸ | F3 | P13726 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6826452 | 0.90 | LOXL2 (0.64) | LOXL2SIRT1MEN1KMT2APCSK9 | |
| SCHEMBL6992345 | 0.88 | SIGMAR1 (0.46) | LOXL2PCSK9DAOCNR1 | |
| SCHEMBL8802664 | 0.84 | LOXL2 (0.57) | LOXL2SIRT1MEN1KMT2APCSK9 | |
| SCHEMBL6824873 | 0.84 | LOXL2 (0.60) | LOXL2SIRT1MEN1KMT2APCSK9 | |
| SCHEMBL866136 | 0.83 | LOXL2 (0.72) | LOXL2SIRT1MEN1KMT2APCSK9 | |
| SCHEMBL6995615 | 0.81 | LOXL2 (0.57) | LOXL2RXFP1PCSK9SMN1; SMN2DAO | |
| SCHEMBL12096730 | 0.80 | SIRT1 (0.56) | LOXL2SIRT1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL6824328 | 0.79 | LOXL2 (0.58) | LOXL2SIRT1MEN1KMT2APCSK9 | |
| SCHEMBL6994522 | 0.79 | LOXL2 (0.53) | LOXL2PCSK9F2CNR1GUSB | |
| SCHEMBL6988904 | 0.79 | CNR1 (0.58) | LOXL2SIRT1PCSK9SMN1; SMN2DAO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1322646-A1 | 2-(1H-INDOL-3-YL)-2-OXO-ACETIC ACID AMIDES WITH ANTITUMOR ACTIVITY | Novuspharma S.p.A. (IT) | 2003-07-02 | — | — | EP | disclosed |
| WO-2002008225-A1 | 2-(1H-INDOL-3-YL)-2-OXO-ACETIC ACID AMIDES WITH ANTITUMOR ACTIVITY | NOVUSPHARMA S.P.A. (IT) | 2002-01-31 | — | — | WO | disclosed |