Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | GLS | O94925 | 2/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.36 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.36 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.36 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.36 |
| ▸ | ACACB | O00763 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | ACACA | Q13085 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5204542 | 0.95 | L3MBTL1 (0.42) | L3MBTL1GLSBRD4ALDH1A1LMNA | |
| SCHEMBL6996710 | 0.83 | NPC1 (0.43) | L3MBTL1ALDH1A1LMNANPSR1SIRT2 | |
| SCHEMBL5209066 | 0.81 | CYP2D6 (0.49) | GLSALDH1A1LMNACYP3A4CYP2C9 | |
| SCHEMBL5214004 | 0.79 | HDAC1 (0.45) | GLSBRD4NR1H4 | |
| SCHEMBL5207728 | 0.78 | NPC1 (0.43) | L3MBTL1ALDH1A1LMNASIRT2SIRT1 | |
| SCHEMBL7431095 | 0.76 | HDAC1 (0.38) | GLSBRD4RAB9ANR1H4NPC1 | |
| Trifluoroacetic Acid SCHEMBL5211180 | 0.76 | NPC1 (0.39) | L3MBTL1ALDH1A1LMNASIRT2SIRT1 | |
| SCHEMBL6993286 | 0.74 | NPC1 (0.37) | L3MBTL1ALDH1A1SIRT2SIRT1SIRT3 | |
| SCHEMBL6992189 | 0.74 | CYP2D6 (0.47) | ALDH1A1LMNACYP3A4CYP2C9RAB9A | |
| SCHEMBL5207716 | 0.72 | MEN1 (0.37) | GLSALDH1A1LMNAPOLBRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1343561-A1 | SERINE PROTEASE INHIBITORS | Tularik Limited (GB) | 2003-09-17 | — | — | EP | disclosed |
| EP-1240154-A1 | SERINE PROTEASE INHIBITORS | Tularik Limited (GB) | 2002-09-18 | — | — | EP | disclosed |
| WO-2002047762-A1 | SERINE PROTEASE INHIBITORS | TULARIK LIMITED (GB) | 2002-06-20 | — | — | WO | disclosed |
| WO-2001044226-A1 | SERINE PROTEASE INHIBITORS | TULARIK LIMITED (GB) | 2001-06-21 | — | — | WO | disclosed |