Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.36 |
| ▸ | PTGES | O14684 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 2/20 | 0.35 |
| ▸ | MMP9 | P14780 | 1/20 | 0.35 |
| ▸ | MMP8 | P22894 | 1/20 | 0.35 |
| ▸ | MMP13 | P45452 | 1/20 | 0.35 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CFTR | P13569 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.34 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6981602 | 0.86 | CYP1A2 (0.38) | PDE10ACYP1A2HIF1AEPAS1PTGES | |
| SCHEMBL6402216 | 0.85 | MMP2 (0.39) | PDE10ACYP1A2HIF1AEPAS1PTGES | |
| SCHEMBL6402218 | 0.85 | MMP2 (0.39) | PDE10ACYP1A2HIF1AEPAS1PTGES | |
| SCHEMBL6988861 | 0.85 | MMP2 (0.38) | CYP1A2HIF1AEPAS1PTGESALOX5 | |
| SCHEMBL6988858 | 0.85 | MMP2 (0.38) | CYP1A2HIF1AEPAS1PTGESALOX5 | |
| SCHEMBL6399014 | 0.85 | MMP2 (0.40) | PDE10ACYP1A2HIF1AEPAS1PTGES | |
| SCHEMBL6399016 | 0.85 | MMP2 (0.40) | PDE10ACYP1A2HIF1AEPAS1PTGES | |
| SCHEMBL6987672 | 0.83 | HDAC3 (0.38) | CYP1A2HIF1AEPAS1PTGESALOX5 | |
| SCHEMBL6987677 | 0.83 | HDAC3 (0.38) | CYP1A2HIF1AEPAS1PTGESALOX5 | |
| SCHEMBL6400533 | 0.83 | CYP1A2 (0.38) | PDE10ACYP1A2HIF1AEPAS1PTGES |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1289980-A1 | BICYCLYL OR HETEROBICYCLYLMETHANESULFONYLAMINO-SUBSTITUTED N-HYDROXYFORMAMIDES | SMITHKLINE BEECHAM PLC (GB) | 2003-03-12 | — | — | EP | claimed |
| WO-2001090100-A1 | BICYCLYL OR HETEROBICYCLYLMETHANESULFONYLAMINO-SUBSTITUTED N-HYDROXYFORMAMIDES | SMITHKLINE BEECHAM P.L.C. (GB) | 2001-11-29 | — | — | WO | claimed |