SCHEMBL6987677

SCHEMBL6987677

CC(CCCS(=O)(=O)Cc1cnc2ccccc2c1)N(O)C=O

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC3 O15379 2/20 0.38
HDAC4 P56524 2/20 0.38
HDAC1 Q13547 2/20 0.38
HDAC7 Q8WUI4 2/20 0.38
HDAC2 Q92769 2/20 0.38
HDAC10 Q969S8 2/20 0.38
HDAC11 Q96DB2 2/20 0.38
HDAC8 Q9BY41 2/20 0.38
HDAC6 Q9UBN7 2/20 0.38
HDAC9 Q9UKV0 2/20 0.38
HDAC5 Q9UQL6 2/20 0.38
KMT2A Q03164 3/20 0.37
MEN1 O00255 2/20 0.37
MMP2 P08253 2/20 0.37
MMP13 P45452 1/20 0.37
CYP1A2 P05177 1/20 0.36
HIF1A Q16665 1/20 0.36
EPAS1 Q99814 1/20 0.36
PTGES O14684 1/20 0.36
ALOX5 P09917 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6987672 1.00 HDAC3 (0.38) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL6988858 0.94 MMP2 (0.38) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL6988861 0.94 MMP2 (0.38) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL6982449 0.84 HIF1A (0.35) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL6990090 0.83 PDE10A (0.37) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL6989198 0.82 CYP1A2 (0.43) KMT2AMEN1MMP2MMP13CYP1A2
SCHEMBL6988734 0.81 CYP1A2 (0.41) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL6988727 0.81 CYP1A2 (0.41) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL6981602 0.81 CYP1A2 (0.38) HDAC3HDAC4HDAC1HDAC7HDAC2
Hydrochloric Acid SCHEMBL6985055 0.81 CYP1A2 (0.42) KMT2AMEN1MMP2MMP13CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1289980-A1 BICYCLYL OR HETEROBICYCLYLMETHANESULFONYLAMINO-SUBSTITUTED N-HYDROXYFORMAMIDES SMITHKLINE BEECHAM PLC (GB) 2003-03-12 EP disclosed
WO-2001090100-A1 BICYCLYL OR HETEROBICYCLYLMETHANESULFONYLAMINO-SUBSTITUTED N-HYDROXYFORMAMIDES SMITHKLINE BEECHAM P.L.C. (GB) 2001-11-29 WO disclosed