Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | PPARD | Q03181 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5429281 | 0.74 | TSHR (0.37) | TSHRTP53TDP1PPARDPOLB | |
| SCHEMBL2471601 | 0.71 | PPARD (0.39) | TSHRTP53TDP1PPARDGAA | |
| SCHEMBL35874 | 0.70 | TSHR (0.44) | TSHRTP53TDP1PPARDPOLB | |
| SCHEMBL887692 | 0.70 | PPARD (0.38) | TSHRTP53TDP1PPARDGAA | |
| SCHEMBL3822346 | 0.69 | POLB (0.48) | TSHRTP53TDP1PPARDPOLB | |
| SCHEMBL4584399 | 0.68 | TSHR (0.52) | TSHRTP53TDP1PPARDPOLB | |
| Potassium Ion SCHEMBL887698 | 0.68 | GAA (0.37) | TSHRTP53TDP1PPARDPOLB | |
| SCHEMBL1477184 | 0.68 | PPARD (0.45) | TSHRTP53TDP1PPARDPOLB | |
| SCHEMBL9791411 | 0.67 | TSHR (0.50) | TSHRTP53TDP1PPARDPOLB | |
| SCHEMBL1107289 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0739345-B1 | CYCLIC POLYAMINES | ANORMED INC (CA) | 2003-04-09 | — | — | EP | disclosed |
| US-5698546-A | Cyclic polyamines | JOHNSON MATTHEY PUBLIC LIMTED COMPANY (GB) | 1997-12-16 | — | — | US | disclosed |
| EP-0739345-A1 | CYCLIC POLYAMINES | JOHNSON MATTHEY PUBLIC LIMITED COMPANY (GB) | 1996-10-30 | — | — | EP | disclosed |
| WO-1995018808-A1 | CYCLIC POLYAMINES | JOHNSON MATTHEY PUBLIC LIMITED COMPANY (GB) | 1995-07-13 | — | — | WO | disclosed |