Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PCSK9 | Q8NBP7 | 4/20 | 0.55 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.50 |
| ▸ | AHR | P35869 | 1/20 | 0.48 |
| ▸ | DAO | P14920 | 1/20 | 0.48 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.47 |
| ▸ | F2 | P00734 | 2/20 | 0.44 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6824328 | 0.87 | LOXL2 (0.58) | PCSK9LOXL2DAOF2HCAR2 | |
| SCHEMBL6619148 | 0.83 | PCSK9 (0.57) | PCSK9LOXL2AHRDAOF2 | |
| SCHEMBL30105384 | 0.83 | LOXL2 (0.60) | PCSK9LOXL2AHROPRK1F2 | |
| SCHEMBL3193871 | 0.83 | LOXL2 (0.60) | PCSK9LOXL2AHROPRK1F2 | |
| Hydrochloric Acid SCHEMBL27754931 | 0.81 | LOXL2 (0.58) | LOXL2AHROPRK1F2 | |
| Bromide SCHEMBL30437340 | 0.81 | LOXL2 (0.58) | PCSK9LOXL2AHROPRK1F2 | |
| SCHEMBL6991621 | 0.81 | PCSK9 (0.50) | PCSK9LOXL2AHRDAOOPRK1 | |
| SCHEMBL6989629 | 0.81 | PCSK9 (0.55) | PCSK9LOXL2AHRDAOOPRK1 | |
| SCHEMBL7494967 | 0.81 | PCSK9 (0.50) | PCSK9LOXL2AHR | |
| SCHEMBL6107658 | 0.80 | PCSK9 (0.48) | PCSK9LOXL2AHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1322646-A1 | 2-(1H-INDOL-3-YL)-2-OXO-ACETIC ACID AMIDES WITH ANTITUMOR ACTIVITY | Novuspharma S.p.A. (IT) | 2003-07-02 | — | — | EP | disclosed |
| EP-1244652-A1 | 2-(1H-INDOL-3-YL)-2-OXO-ACETAMIDES WITH ANTITUMOR ACTIVITY | Cell Therapeutics Europe S.R.L. (IT) | 2002-10-02 | — | — | EP | disclosed |
| WO-2002008225-A1 | 2-(1H-INDOL-3-YL)-2-OXO-ACETIC ACID AMIDES WITH ANTITUMOR ACTIVITY | NOVUSPHARMA S.P.A. (IT) | 2002-01-31 | — | — | WO | disclosed |
| WO-2001047916-A1 | 2-(1H-INDOL-3-YL)-2-OXO-ACETAMIDES WITH ANTITUMOR ACTIVITY | NOVUSPHARMA S.P.A. (IT) | 2001-07-05 | — | — | WO | disclosed |