Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 4/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14078822 | 1.00 | CHRM2 (0.41) | CHRM2CHRM1CHRM4CHRM3CHRNA7 | |
| SCHEMBL6990202 | 1.00 | CHRM2 (0.41) | CHRM2CHRM1CHRM4CHRM3CHRNA7 | |
| Hydrochloric Acid SCHEMBL2419739 | 0.98 | CHRM2 (0.40) | CHRM2CHRM1CHRM4CHRM3CHRNA7 | |
| Hydrochloric Acid SCHEMBL2419742 | 0.98 | CHRM2 (0.40) | CHRM2CHRM1CHRM4CHRM3CHRNA7 | |
| SCHEMBL6556633 | 0.89 | ALDH1A1 (0.46) | CHRM2CHRM1CHRM4CHRM3CHRNA7 | |
| SCHEMBL5167294 | 0.89 | ALDH1A1 (0.46) | CHRM2CHRM1CHRM4CHRM3CHRNA7 | |
| SCHEMBL5108694 | 0.89 | ALDH1A1 (0.46) | CHRM2CHRM1CHRM4CHRM3CHRNA7 | |
| Hydrochloric Acid SCHEMBL15329263 | 0.87 | ALDH1A1 (0.49) | CHRM2CHRM1CHRM4CHRM3CHRNA7 | |
| Hydrochloric Acid SCHEMBL5471959 | 0.87 | ALDH1A1 (0.49) | CHRM2CHRM1CHRM4CHRM3CHRNA7 | |
| Hydrochloric Acid SCHEMBL2491331 | 0.87 | ALDH1A1 (0.49) | CHRM2CHRM1CHRM4CHRM3CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0874809-B1 | CARBAMOYLOXY DERIVATIVES OF MUTILINE AND THEIR USE AS ANTIBACTERIALS | SMITHKLINE BEECHAM PLC (GB) | 2003-08-27 | — | — | EP | disclosed |
| EP-0934316-B1 | AZABICYCLIC CARBAMOYLOXY MUTILIN DERIVATIVES FOR ANTIBACTERIAL USE | SMITHKLINE BEECHAM PLC (GB) | 2002-10-16 | — | — | EP | disclosed |
| US-6239175-B1 | Carbamoyloxy derivatives of mutiline and their use as antibacterials | SMITHKLINE BEECHAM P.L.C. (GB) | 2001-05-29 | — | — | US | disclosed |
| US-6121281-A | Azabicyclic carbamoyloxy mutilin derivatives for antibacterial use | SMITHKLINE BEECHAM P.L.C. (GB) | 2000-09-19 | — | — | US | disclosed |
| US-6020368-A | MICROBIOCIDES | HINKS JEREMY DAVID (US) | 2000-02-01 | — | — | US | disclosed |
| EP-0934316-A1 | AZABICYCLIC CARBAMOYLOXY MUTILIN DERIVATIVES FOR ANTIBACTERIAL USE | SMITHKLINE BEECHAM PLC (GB) | 1999-08-11 | — | — | EP | disclosed |
| WO-1998005659-A1 | AZABICYCLIC CARBAMOYLOXY MUTILIN DERIVATIVES FOR ANTIBACTERIAL USE | SMITHKLINE BEECHAM PLC (GB) | 1998-02-12 | — | — | WO | disclosed |