Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 5/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | CTSS | P25774 | 6/20 | 0.42 |
| ▸ | CTSK | P43235 | 4/20 | 0.42 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | ACE | P12821 | 1/20 | 0.37 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.37 |
| ▸ | CTSL | P07711 | 1/20 | 0.36 |
| ▸ | CTSB | P07858 | 1/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.36 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.36 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29364846 | 1.00 | DPP4 (0.43) | DPP4ATMCTSSCTSKAAK1 | |
| SCHEMBL342708 | 1.00 | DPP4 (0.43) | DPP4ATMCTSSCTSKAAK1 | |
| SCHEMBL28759095 | 1.00 | DPP4 (0.43) | DPP4ATMCTSSCTSKAAK1 | |
| SCHEMBL27791284 | 0.91 | DPP4 (0.40) | DPP4ATMCTSSCTSKAAK1 | |
| SCHEMBL571933 | 0.91 | CTSS (0.41) | DPP4ATMCTSSCTSKAAK1 | |
| SCHEMBL10057576 | 0.91 | CTSS (0.41) | DPP4ATMCTSSCTSKAAK1 | |
| SCHEMBL1509212 | 0.90 | AAK1 (0.45) | DPP4ATMCTSSCTSKAAK1 | |
| SCHEMBL2364292 | 0.90 | AAK1 (0.45) | DPP4ATMCTSSCTSKAAK1 | |
| SCHEMBL344600 | 0.90 | DPP4 (0.43) | DPP4ATMCTSSCTSKAAK1 | |
| SCHEMBL19500634 | 0.90 | DPP4 (0.43) | DPP4ATMCTSSCTSKAAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 473 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116554060-B | Preparation method of Boc- (R) -3-amino-4- (2, 4, 5-trifluorophenyl) butyric acid | 江苏八巨药业有限公司 | 2024-11-15 | — | — | CN | claimed |
| CN-118908861-A | Preparation method of Boc- (R) -3-amino-4- (2, 4, 5-trifluorophenyl) butyric acid, intermediate I and preparation method thereof | 台州达辰药业有限公司 | 2024-11-08 | — | — | CN | claimed |
| CN-116554060-A | Preparation method of Boc- (R) -3-amino-4- (2, 4, 5-trifluorophenyl) butyric acid | 江苏八巨药业有限公司 | 2023-08-08 | — | — | CN | claimed |
| CN-115385919-A | Synthetic method of sitagliptin | 江苏阿尔法药业股份有限公司 | 2022-11-25 | — | — | CN | claimed |
| CN-112500316-B | Method for preparing BOC- (R) -3-amino-4- (2,4,5-trifluorophenyl) butyric acid | 浙江永太手心医药科技有限公司 | 2022-11-08 | — | — | CN | claimed |
| CN-113979896-A | Sitagliptin impurity I and preparation method thereof | 浙江永太手心医药科技有限公司 | 2022-01-28 | — | — | CN | claimed |
| CN-107286164-B | Application of compound in preparation of sitagliptin and method for preparing sitagliptin | 武汉臻智生物科技有限公司 | 2021-08-03 | — | — | CN | claimed |
| CN-109824546-B | BOC- (R) -3-amino-4- (2,4, 5-trifluorophenyl) butyric acid condensation impurity and preparation method thereof | 浙江永太科技股份有限公司 | 2021-07-02 | — | — | CN | claimed |
| CN-112500316-A | Method for preparing BOC- (R) -3-amino-4- (2,4, 5-trifluorophenyl) butyric acid | 浙江永太手心医药科技有限公司 | 2021-03-16 | — | — | CN | claimed |
| CN-112195201-A | Application of stereoselective transaminase in asymmetric synthesis of chiral amine | 弈柯莱生物科技(上海)股份有限公司 | 2021-01-08 | — | — | CN | claimed |
| US-20200157587-A1 | USE OFSTEREOSELECTIVE TRANSAMINASE IN ASYMMETRIC SYNTHESIS OF CHIRAL AMINE | Abiochem Biotechnology (Group) Co., Ltd. (CN) | 2020-05-21 | — | — | US | claimed |
| EP-3650537-A1 | USE OF STEREOSELECTIVE TRANSAMINASE IN ASYMMETRIC SYNTHESIS OF CHIRAL AMINE | Abiochem Biotechnology Co., Ltd. (CN) | 2020-05-13 | — | — | EP | claimed |
| CN-111057061-A | Preparation method of tert-butoxycarbonyl-sitagliptin | 台州保灵药业有限公司 | 2020-04-24 | — | — | CN | claimed |
| CN-110914417-A | Application of stereoselective transaminase in asymmetric synthesis of chiral amine | 上海弈柯莱生物医药科技有限公司 | 2020-03-24 | — | — | CN | claimed |
| CN-109824546-A | BOC- (R) -3- amino -4- (2,4,5- trifluorophenyl) butyric acid is condensed impurity and preparation method thereof | 浙江永太科技股份有限公司 | 2019-05-31 | — | — | CN | claimed |
| CN-107286164-A | Purposes of the compound in sitagliptin is prepared and the method for preparing sitagliptin | 武汉臻智生物科技有限公司 | 2017-10-24 | — | — | CN | claimed |
| US-9409912-B2 | Process for the preparation of sitagliptin phosphate | CADILA HEALTHCARE LIMITED (IN) | 2016-08-09 | — | — | US | claimed |
| US-20150087834-A1 | PROCESS FOR THE PREPARATION OF SITAGLIPTIN PHOSPHATE | CADILA HEALTHCARE LIMITED (IN) | 2015-03-26 | — | — | US | claimed |
| WO-2010122578-A2 | PROCESS FOR THE PREPARATION OF SITAGLIPTIN AND ITS INTERMEDIATES | MSN LABORATORIES LIMITED (IN) | 2010-10-28 | — | — | WO | claimed |
| CN-116554060-B | Preparation method of Boc- (R) -3-amino-4- (2, 4, 5-trifluorophenyl) butyric acid | 江苏八巨药业有限公司 | 2024-11-15 | — | — | CN | disclosed |
| CN-116554060-B | Preparation method of Boc- (R) -3-amino-4- (2, 4, 5-trifluorophenyl) butyric acid | 江苏八巨药业有限公司 | 2024-11-15 | — | — | CN | disclosed |
| CN-116554060-B | Preparation method of Boc- (R) -3-amino-4- (2, 4, 5-trifluorophenyl) butyric acid | 江苏八巨药业有限公司 | 2024-11-15 | — | — | CN | disclosed |
| CN-118908861-A | Preparation method of Boc- (R) -3-amino-4- (2, 4, 5-trifluorophenyl) butyric acid, intermediate I and preparation method thereof | 台州达辰药业有限公司 | 2024-11-08 | — | — | CN | disclosed |
| CN-118908861-A | Preparation method of Boc- (R) -3-amino-4- (2, 4, 5-trifluorophenyl) butyric acid, intermediate I and preparation method thereof | 台州达辰药业有限公司 | 2024-11-08 | — | — | CN | disclosed |
| CN-118908861-A | Preparation method of Boc- (R) -3-amino-4- (2, 4, 5-trifluorophenyl) butyric acid, intermediate I and preparation method thereof | 台州达辰药业有限公司 | 2024-11-08 | — | — | CN | disclosed |
| CN-118063351-B | Green synthesis of chiral beta amino acids using biological enzymes and immobilized aminotransferase used | 北京元延医药科技股份有限公司 | 2024-06-28 | — | — | CN | disclosed |
| US-20240174675-A1 | SMALL MOLECULE REGULATORS OF ALVEOLAR TYPE 2 CELL PROLIFERATION FOR THE TREATMENT OF PULMONARY DISEASES | THE SCRIPPS RESEARCH INSTITUTE | 2024-05-30 | — | — | US | disclosed |
| CN-118063351-A | Green synthesis of chiral beta amino acids using biological enzymes and immobilized aminotransferase used | 北京元延医药科技股份有限公司 | 2024-05-24 | — | — | CN | disclosed |
| US-11965193-B2 | Use of stereoselective transaminase in asymmetric synthesis of chiral amine | ABIOCHEM BIOTECHNOLOGY CO., LTD (CN) | 2024-04-23 | — | — | US | disclosed |
| CN-117843643-A | Preparation method of sitagliptin phosphate | 北京诺康达医药科技股份有限公司 | 2024-04-09 | — | — | CN | disclosed |
| CN-116333019-B | Fluorocytidine compound and preparation method and application thereof | 沈阳农业大学 | 2024-04-02 | — | — | CN | disclosed |
| CN-115819260-B | Synthesis process of sitagliptin intermediate | 江苏阿尔法药业股份有限公司 | 2024-03-19 | — | — | CN | disclosed |
| CN-117467733-B | High chiral purity sitagliptin and method for preparing same by using immobilized transaminase | 北京元延医药科技股份有限公司 | 2024-03-12 | — | — | CN | disclosed |
| CN-117603213-A | Synthesis method of sitagliptin phosphate | 安徽美诺华药物化学有限公司 | 2024-02-27 | — | — | CN | disclosed |
| CN-117467733-A | High chiral purity sitagliptin and method for preparing same by using immobilized transaminase | 北京元延医药科技股份有限公司 | 2024-01-30 | — | — | CN | disclosed |
| WO-2024015889-A2 | SMALL MOLECULE REGULATORS OF ALVEOLAR TYPE 2 CELL PROLIFERATION FOR THE TREATMENT OF PULMONARY DISEASES | THE SCRIPPS RESEARCH INSTITUTE (US) | 2024-01-18 | — | — | WO | disclosed |
| CN-111039900-B | Preparation method of 1-morpholine-4- (2, 4, 5-trifluoro-phenyl) butane-1, 3-dione | 弈柯莱生物科技(集团)股份有限公司 | 2023-12-22 | — | — | CN | disclosed |
| CN-117177958-A | Small molecule modulators of alveolar type 2cell proliferation for the treatment of pulmonary diseases | 斯克里普斯研究学院 | 2023-12-05 | — | — | CN | disclosed |
| WO-2023181046-A1 | RECYCLABLE BIOCATALYTIC PROCESS FOR PREPARATION OF SITAGLIPTIN | IOL CHEMICALS AND PHARMACEUTICALS LIMITED (IN) | 2023-09-28 | — | — | WO | disclosed |
| CN-115266973-B | Method for separating and measuring related substances of DPP-IV inhibitor | 盛世泰科生物医药技术(苏州)有限公司 | 2023-08-18 | — | — | CN | disclosed |
| CN-116554060-A | Preparation method of Boc- (R) -3-amino-4- (2, 4, 5-trifluorophenyl) butyric acid | 江苏八巨药业有限公司 | 2023-08-08 | — | — | CN | disclosed |
| CN-116554060-A | Preparation method of Boc- (R) -3-amino-4- (2, 4, 5-trifluorophenyl) butyric acid | 江苏八巨药业有限公司 | 2023-08-08 | — | — | CN | disclosed |
| CN-116554060-A | Preparation method of Boc- (R) -3-amino-4- (2, 4, 5-trifluorophenyl) butyric acid | 江苏八巨药业有限公司 | 2023-08-08 | — | — | CN | disclosed |
| US-20230203550-A1 | USE OF STEREOSELECTIVE TRANSAMINASE IN ASYMMETRIC SYNTHESIS OF CHIRAL AMINE | ABIOCHEM BIOTECHNOLOGY CO., LTD (CN) | 2023-06-29 | — | — | US | disclosed |
| US-20230203550-A1 | USE OF STEREOSELECTIVE TRANSAMINASE IN ASYMMETRIC SYNTHESIS OF CHIRAL AMINE | ABIOCHEM BIOTECHNOLOGY CO., LTD (CN) | 2023-06-29 | — | — | US | disclosed |
| US-20230203550-A1 | USE OF STEREOSELECTIVE TRANSAMINASE IN ASYMMETRIC SYNTHESIS OF CHIRAL AMINE | ABIOCHEM BIOTECHNOLOGY CO., LTD (CN) | 2023-06-29 | — | — | US | disclosed |
| CN-116333019-A | Fluorocytidine compound and preparation method and application thereof | 沈阳农业大学 | 2023-06-27 | — | — | CN | disclosed |
| US-20230174461-A1 | METHOD FOR PREPARING CHIRAL 4-ARYL-ß-AMINO ACID DERIVATIVE | ZHEJIANG MEDICINE CO., LTD. XINCHANG PHARMACEUTICAL FACTORY (CN) | 2023-06-08 | — | — | US | disclosed |
| US-20230174461-A1 | METHOD FOR PREPARING CHIRAL 4-ARYL-ß-AMINO ACID DERIVATIVE | ZHEJIANG MEDICINE CO., LTD. XINCHANG PHARMACEUTICAL FACTORY (CN) | 2023-06-08 | — | — | US | disclosed |
| CN-113773323-B | Preparation method of 3R-amino substituted butyramide derivative | 江苏恒瑞医药股份有限公司 | 2023-05-12 | — | — | CN | disclosed |
| CN-115975969-A | Transaminase and use thereof for the preparation of sitagliptin or an intermediate thereof | 弈柯莱生物科技(上海)股份有限公司 | 2023-04-18 | — | — | CN | disclosed |
| CN-115819260-A | Synthesis process of sitagliptin intermediate | 江苏阿尔法药业股份有限公司 | 2023-03-21 | — | — | CN | disclosed |
| US-20220387427-A1 | ORAL GLIPTIN COMPOSITIONS AND METHOD FOR PREPARATION THEREOF | PHARMA-DATA RESEARCH AND DEVELOPMENT SINGLE MEMBER S.A. (GR) | 2022-12-08 | — | — | US | disclosed |
| CN-115385919-A | Synthetic method of sitagliptin | 江苏阿尔法药业股份有限公司 | 2022-11-25 | — | — | CN | disclosed |
| CN-115385919-A | Synthetic method of sitagliptin | 江苏阿尔法药业股份有限公司 | 2022-11-25 | — | — | CN | disclosed |
| US-11499172-B2 | Use of stereoselective transaminase in asymmetric synthesis of chiral amine | ABIOCHEM BIOTECHNOLOGY CO., LTD. (CN) | 2022-11-15 | — | — | US | disclosed |
| CN-112500316-B | Method for preparing BOC- (R) -3-amino-4- (2,4,5-trifluorophenyl) butyric acid | 浙江永太手心医药科技有限公司 | 2022-11-08 | — | — | CN | disclosed |
| CN-112500316-B | Method for preparing BOC- (R) -3-amino-4- (2,4,5-trifluorophenyl) butyric acid | 浙江永太手心医药科技有限公司 | 2022-11-08 | — | — | CN | disclosed |
| CN-112500316-B | Method for preparing BOC- (R) -3-amino-4- (2,4,5-trifluorophenyl) butyric acid | 浙江永太手心医药科技有限公司 | 2022-11-08 | — | — | CN | disclosed |
| CN-115266973-A | Method for separating and measuring DPP-IV inhibitor related substances | 盛世泰科生物医药技术(苏州)有限公司 | 2022-11-01 | — | — | CN | disclosed |
| CN-111039901-B | Process for producing 1, 3-dicarbonyl compound and intermediate thereof | 弈柯莱生物科技(上海)股份有限公司 | 2022-10-11 | — | — | CN | disclosed |
| US-20220153772-A1 | GLUCOSIDE DERIVATIVE THAT ACTS AS SGLT1 INHIBITOR AND APPLICATION THEREOF | MEDSHINE DISCOVERY INC. (CN) | 2022-05-19 | — | — | US | disclosed |
| CN-114057751-B | Preparation method of DPP-IV inhibitor and key intermediate thereof | 盛世泰科生物医药技术(苏州)有限公司 | 2022-04-12 | — | — | CN | disclosed |
| CN-109896980-B | Biosynthesis method of sitagliptin intermediate | 浙江九洲药业股份有限公司 | 2022-04-08 | — | — | CN | disclosed |
| CN-114057751-A | Preparation method of DPP-IV inhibitor and key intermediate thereof | 盛世泰科生物医药技术(苏州)有限公司 | 2022-02-18 | — | — | CN | disclosed |
| CN-113979896-A | Sitagliptin impurity I and preparation method thereof | 浙江永太手心医药科技有限公司 | 2022-01-28 | — | — | CN | disclosed |
| CN-113773323-A | Preparation method of 3R-amino substituted butanamide derivative | 江苏恒瑞医药股份有限公司 | 2021-12-10 | — | — | CN | disclosed |
| CN-113461691-A | Sitagliptin impurity, preparation method and detection method thereof | 浙江美诺华药物化学有限公司 | 2021-10-01 | — | — | CN | disclosed |
| CN-107286164-B | Application of compound in preparation of sitagliptin and method for preparing sitagliptin | 武汉臻智生物科技有限公司 | 2021-08-03 | — | — | CN | disclosed |
| CN-113149991-A | Synthesis method of sitagliptin free base and sitagliptin phosphate monohydrate | 浙江美诺华药物化学有限公司 | 2021-07-23 | — | — | CN | disclosed |
| CN-109824546-B | BOC- (R) -3-amino-4- (2,4, 5-trifluorophenyl) butyric acid condensation impurity and preparation method thereof | 浙江永太科技股份有限公司 | 2021-07-02 | — | — | CN | disclosed |
| CN-109824546-B | BOC- (R) -3-amino-4- (2,4, 5-trifluorophenyl) butyric acid condensation impurity and preparation method thereof | 浙江永太科技股份有限公司 | 2021-07-02 | — | — | CN | disclosed |
| CN-109824546-B | BOC- (R) -3-amino-4- (2,4, 5-trifluorophenyl) butyric acid condensation impurity and preparation method thereof | 浙江永太科技股份有限公司 | 2021-07-02 | — | — | CN | disclosed |
| EP-3811930-A1 | ORAL GLIPTIN COMPOSITIONS AND METHOD FOR PREPARATION THEREOF | Authenda Pharmaceuticals AG (CH) | 2021-04-28 | — | — | EP | disclosed |
| CN-112500316-A | Method for preparing BOC- (R) -3-amino-4- (2,4, 5-trifluorophenyl) butyric acid | 浙江永太手心医药科技有限公司 | 2021-03-16 | — | — | CN | disclosed |
| CN-112500316-A | Method for preparing BOC- (R) -3-amino-4- (2,4, 5-trifluorophenyl) butyric acid | 浙江永太手心医药科技有限公司 | 2021-03-16 | — | — | CN | disclosed |
| CN-112500316-A | Method for preparing BOC- (R) -3-amino-4- (2,4, 5-trifluorophenyl) butyric acid | 浙江永太手心医药科技有限公司 | 2021-03-16 | — | — | CN | disclosed |
| CN-112195201-A | Application of stereoselective transaminase in asymmetric synthesis of chiral amine | 弈柯莱生物科技(上海)股份有限公司 | 2021-01-08 | — | — | CN | disclosed |
| CN-110914417-B | Application of stereoselective transaminase in asymmetric synthesis of chiral amine | 弈柯莱生物科技(上海)股份有限公司 | 2020-10-27 | — | — | CN | disclosed |
| EP-3156391-B1 | METHOD FOR PREPARING SITAGLIPTIN INTERMEDIATE VIA ASYMMETRICAL REDUCTION METHOD | ZHEJIANG HUAHAI PHARM CO LTD (CN) | 2020-09-02 | — | — | EP | disclosed |
| EP-3156391-B1 | METHOD FOR PREPARING SITAGLIPTIN INTERMEDIATE VIA ASYMMETRICAL REDUCTION METHOD | ZHEJIANG HUAHAI PHARM CO LTD (CN) | 2020-09-02 | — | — | EP | disclosed |
| US-20200206221-A1 | BETA-AMINO HETEROCYCLIC DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES | MERCK SHARP & DOHME CORP. (US) | 2020-07-02 | — | — | US | disclosed |
| US-20200206221-A1 | BETA-AMINO HETEROCYCLIC DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES | MERCK SHARP & DOHME CORP. (US) | 2020-07-02 | — | — | US | disclosed |
| WO-2020109938-A1 | PROCESSES FOR THE PREPARATION OF SITAGLIPTIN AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF | DR. REDDY'S LABORATORIES LIMITED (IN) | 2020-06-04 | — | — | WO | disclosed |
| US-20200157587-A1 | USE OFSTEREOSELECTIVE TRANSAMINASE IN ASYMMETRIC SYNTHESIS OF CHIRAL AMINE | Abiochem Biotechnology (Group) Co., Ltd. (CN) | 2020-05-21 | — | — | US | disclosed |
| US-20200157587-A1 | USE OFSTEREOSELECTIVE TRANSAMINASE IN ASYMMETRIC SYNTHESIS OF CHIRAL AMINE | Abiochem Biotechnology (Group) Co., Ltd. (CN) | 2020-05-21 | — | — | US | disclosed |
| EP-3650537-A1 | USE OF STEREOSELECTIVE TRANSAMINASE IN ASYMMETRIC SYNTHESIS OF CHIRAL AMINE | Abiochem Biotechnology Co., Ltd. (CN) | 2020-05-13 | — | — | EP | disclosed |
| EP-3650537-A1 | USE OF STEREOSELECTIVE TRANSAMINASE IN ASYMMETRIC SYNTHESIS OF CHIRAL AMINE | Abiochem Biotechnology Co., Ltd. (CN) | 2020-05-13 | — | — | EP | disclosed |
| CN-111057061-A | Preparation method of tert-butoxycarbonyl-sitagliptin | 台州保灵药业有限公司 | 2020-04-24 | — | — | CN | disclosed |
| CN-111057061-A | Preparation method of tert-butoxycarbonyl-sitagliptin | 台州保灵药业有限公司 | 2020-04-24 | — | — | CN | disclosed |
| CN-111039901-A | Process for producing 1, 3-dicarbonyl compound and intermediate thereof | 上海弈柯莱生物医药科技有限公司 | 2020-04-21 | — | — | CN | disclosed |
| CN-111039900-A | Preparation method of 1-morpholine-4- (2,4, 5-trifluorophenyl) butane-1, 3-dione | 上海弈柯莱生物医药科技有限公司 | 2020-04-21 | — | — | CN | disclosed |
| CN-106458853-B | Method for preparing sitagliptin intermediate by asymmetric reduction method | 浙江华海药业股份有限公司 | 2020-03-27 | — | — | CN | disclosed |
| CN-110914417-A | Application of stereoselective transaminase in asymmetric synthesis of chiral amine | 上海弈柯莱生物医药科技有限公司 | 2020-03-24 | — | — | CN | disclosed |
| US-10450315-B2 | Process for the preparation of dipeptidyl peptidase-4 (DPP-4) enzyme inhibitor | LEE PHARMA LIMITED (IN) | 2019-10-22 | — | — | US | disclosed |
| CN-105669682-B | A kind of intermediate of DPP-IV inhibitor | 成都先导药物开发股份有限公司 | 2019-08-30 | — | — | CN | disclosed |
| CN-109896980-A | A kind of biological synthesis method of sitagliptin intermediate | 浙江九洲药业股份有限公司 | 2019-06-18 | — | — | CN | disclosed |
| CN-109824546-A | BOC- (R) -3- amino -4- (2,4,5- trifluorophenyl) butyric acid is condensed impurity and preparation method thereof | 浙江永太科技股份有限公司 | 2019-05-31 | — | — | CN | disclosed |
| CN-109824546-A | BOC- (R) -3- amino -4- (2,4,5- trifluorophenyl) butyric acid is condensed impurity and preparation method thereof | 浙江永太科技股份有限公司 | 2019-05-31 | — | — | CN | disclosed |
| CN-109824546-A | BOC- (R) -3- amino -4- (2,4,5- trifluorophenyl) butyric acid is condensed impurity and preparation method thereof | 浙江永太科技股份有限公司 | 2019-05-31 | — | — | CN | disclosed |
| US-10189760-B2 | Method for preparing sitagliptin intermediate via asymmetrical reduction method | ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD. (CN) | 2019-01-29 | — | — | US | disclosed |
| US-10189760-B2 | Method for preparing sitagliptin intermediate via asymmetrical reduction method | ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD. (CN) | 2019-01-29 | — | — | US | disclosed |
| US-20180086765-A1 | NOVEL INTERMEDIATES FOR PREPARING DPP-IV INHIBITORS, PREPARING METHOD THEREOF AND PREPARING METHOD OF DPP-IV INHIBITORS USING THE SAME | KYUNG DONG PHARM. CO., LTD. (KR) | 2018-03-29 | — | — | US | disclosed |
| US-20180086765-A1 | NOVEL INTERMEDIATES FOR PREPARING DPP-IV INHIBITORS, PREPARING METHOD THEREOF AND PREPARING METHOD OF DPP-IV INHIBITORS USING THE SAME | KYUNG DONG PHARM. CO., LTD. (KR) | 2018-03-29 | — | — | US | disclosed |
| US-20180086765-A1 | NOVEL INTERMEDIATES FOR PREPARING DPP-IV INHIBITORS, PREPARING METHOD THEREOF AND PREPARING METHOD OF DPP-IV INHIBITORS USING THE SAME | KYUNG DONG PHARM. CO., LTD. (KR) | 2018-03-29 | — | — | US | disclosed |
| US-9873651-B2 | — | — | 2018-01-23 | — | — | US | disclosed |
| US-9873651-B2 | — | — | 2018-01-23 | — | — | US | disclosed |
| US-9873651-B2 | — | — | 2018-01-23 | — | — | US | disclosed |
| EP-3262025-A1 | NOVEL INTERMEDIATES FOR PREPARING DPP-IV INHIBITORS, PREPARING METHOD THEREOF AND PREPARING METHOD OF DPP-IV INHIBITORS USING THE SAME | Kyung Dong Pharm. Co., Ltd. (KR) | 2018-01-03 | — | — | EP | disclosed |
| US-20170348309-A1 | BETA-AMINO HETEROCYCLIC DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES | MERCK SHARP & DOHME (US) | 2017-12-07 | — | — | US | disclosed |
| US-20170348309-A1 | BETA-AMINO HETEROCYCLIC DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES | MERCK SHARP & DOHME (US) | 2017-12-07 | — | — | US | disclosed |
| US-20170348309-A1 | BETA-AMINO HETEROCYCLIC DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES | MERCK SHARP & DOHME (US) | 2017-12-07 | — | — | US | disclosed |
| EP-2404921-B1 | SALTS OF TETRAHYDROIMIDAZO[1,5-a]PYRAZINE DERIVATIVES, PREPARATION METHODS AND PHARMACEUTICAL USE THEREOF | JIANGSU HENGRUI MEDICINE CO (CN) | 2017-11-22 | — | — | EP | disclosed |
| EP-2404921-B1 | SALTS OF TETRAHYDROIMIDAZO[1,5-a]PYRAZINE DERIVATIVES, PREPARATION METHODS AND PHARMACEUTICAL USE THEREOF | JIANGSU HENGRUI MEDICINE CO (CN) | 2017-11-22 | — | — | EP | disclosed |
| EP-2351567-B1 | PHARMACEUTICAL COMPOSITION FOR PREVENTION AND TREATMENT OF DIABETES OR OBESITY COMPRISING A COMPOUND THAT INHIBITS ACTIVITY OF DIPEPTIDYL PEPTIDASE-IV, AND OTHER ANTIDIABETIC OR ANTIOBESITY AGENTS AS ACTIVE INGREDIENTS | DONG A ST CO LTD (KR) | 2017-11-22 | — | — | EP | disclosed |
| US-20170305822-A1 | METHOD FOR PREPARING SITAGLIPTIN INTERMEDIATE VIA ASYMMETRICAL REDUCTION METHOD | ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD. (CN) | 2017-10-26 | — | — | US | disclosed |
| US-20170305822-A1 | METHOD FOR PREPARING SITAGLIPTIN INTERMEDIATE VIA ASYMMETRICAL REDUCTION METHOD | ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD. (CN) | 2017-10-26 | — | — | US | disclosed |
| US-20170305822-A1 | METHOD FOR PREPARING SITAGLIPTIN INTERMEDIATE VIA ASYMMETRICAL REDUCTION METHOD | ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD. (CN) | 2017-10-26 | — | — | US | disclosed |
| CN-107286164-A | Purposes of the compound in sitagliptin is prepared and the method for preparing sitagliptin | 武汉臻智生物科技有限公司 | 2017-10-24 | — | — | CN | disclosed |
| EP-3156391-A1 | METHOD FOR PREPARING SITAGLIPTIN INTERMEDIATE VIA ASYMMETRICAL REDUCTION METHOD | Zhejiang Huahai Pharmaceutical Co., Ltd (CN) | 2017-04-19 | — | — | EP | disclosed |
| EP-3156391-A1 | METHOD FOR PREPARING SITAGLIPTIN INTERMEDIATE VIA ASYMMETRICAL REDUCTION METHOD | Zhejiang Huahai Pharmaceutical Co., Ltd (CN) | 2017-04-19 | — | — | EP | disclosed |
| EP-2736909-B1 | PROCESS FOR THE PREPARATION OF SITAGLIPTIN AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS | FARMA GRS D O O (SI) | 2017-03-29 | — | — | EP | disclosed |
| EP-2820019-B1 | NOVEL CRYSTALLINE FORM OF SITAGLIPTIN SULFATE | MOEHS IBÉRICA S L (ES) | 2017-03-22 | — | — | EP | disclosed |
| EP-2820019-B1 | NOVEL CRYSTALLINE FORM OF SITAGLIPTIN SULFATE | MOEHS IBÉRICA S L (ES) | 2017-03-22 | — | — | EP | disclosed |
| CN-102603749-B | Synthesis method of sitagliptin intermediate | 浙江华海药业股份有限公司 | 2017-02-08 | — | — | CN | disclosed |
| CN-102603749-B | Synthesis method of sitagliptin intermediate | 浙江华海药业股份有限公司 | 2017-02-08 | — | — | CN | disclosed |
| WO-2016204376-A1 | NOVEL INTERMEDIATES FOR PREPARING DPP-IV INHIBITORS, PREPARING METHOD THEREOF AND PREPARING METHOD OF DPP-IV INHIBITORS USING THE SAME | KYUNG DONG PHARM. CO., LTD. (KR) | 2016-12-22 | — | — | WO | disclosed |
| WO-2016204376-A1 | NOVEL INTERMEDIATES FOR PREPARING DPP-IV INHIBITORS, PREPARING METHOD THEREOF AND PREPARING METHOD OF DPP-IV INHIBITORS USING THE SAME | KYUNG DONG PHARM. CO., LTD. (KR) | 2016-12-22 | — | — | WO | disclosed |
| EP-2647624-B1 | INTERMEDIATES OF SITAGLIPTIN AND PREPARATION PROCESS THEREOF | ZHEJIANG HISOAR PHARMACEUTICAL CO LTD (CN) | 2016-10-12 | — | — | EP | disclosed |
| EP-2381772-B1 | PROCESS AND INTERMEDIATES FOR THE PREPARATION OF N-ACYLATED-4-ARYL BETA-AMINO ACID DERIVATIVES | CHIRAL QUEST INC (US) | 2016-08-24 | — | — | EP | disclosed |
| EP-2381772-B1 | PROCESS AND INTERMEDIATES FOR THE PREPARATION OF N-ACYLATED-4-ARYL BETA-AMINO ACID DERIVATIVES | CHIRAL QUEST INC (US) | 2016-08-24 | — | — | EP | disclosed |
| US-9409912-B2 | Process for the preparation of sitagliptin phosphate | CADILA HEALTHCARE LIMITED (IN) | 2016-08-09 | — | — | US | disclosed |
| US-9409912-B2 | Process for the preparation of sitagliptin phosphate | CADILA HEALTHCARE LIMITED (IN) | 2016-08-09 | — | — | US | disclosed |
| US-9409912-B2 | Process for the preparation of sitagliptin phosphate | CADILA HEALTHCARE LIMITED (IN) | 2016-08-09 | — | — | US | disclosed |
| WO-2016110750-A1 | NOVEL PROCESS FOR THE PREPARATION OF DIPEPTIDYL PEPTIDASE-4 (DPP-4) ENZYME INHIBITOR | LEE PHARMA LIMITED (IN) | 2016-07-14 | — | — | WO | disclosed |
| US-9388188-B2 | Synthetic route for the preparation of β-aminobutyryl substituted 5,6,7,8-tetrahydro[1,4]diazolo[4,3-alpha ]pyrazin-7-yl compounds | LEK PHARMACEUTICALS D.D. (SI) | 2016-07-12 | — | — | US | disclosed |
| US-9388188-B2 | Synthetic route for the preparation of β-aminobutyryl substituted 5,6,7,8-tetrahydro[1,4]diazolo[4,3-alpha ]pyrazin-7-yl compounds | LEK PHARMACEUTICALS D.D. (SI) | 2016-07-12 | — | — | US | disclosed |
| US-20160194680-A1 | Enzymatic Route For The Preparation Of Chiral Gamma-Aryl-Beta-Aminobutyric Acid Derivatives | LEK PHARMACEUTICALS D.D. (SI) | 2016-07-07 | — | — | US | disclosed |
| US-20160194680-A1 | Enzymatic Route For The Preparation Of Chiral Gamma-Aryl-Beta-Aminobutyric Acid Derivatives | LEK PHARMACEUTICALS D.D. (SI) | 2016-07-07 | — | — | US | disclosed |
| EP-2576563-B1 | A NOVEL SYNTHETIC APPROACH TO ß-AMINOBUTYRYL SUBSTITUTED COMPOUNDS | LEK PHARMACEUTICALS (SI) | 2016-05-11 | — | — | EP | disclosed |
| CN-103922971-B | For the preparation of improving one's methods of the intermediate of dipeptidyl peptidase-iv inhibitor | DONG-A ST CO., LTD. (KR) | 2016-05-11 | — | — | CN | disclosed |
| CN-102757431-B | A kind of novel method of synthesizing sitagliptin | ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD. (CN) | 2016-03-30 | — | — | CN | disclosed |
| EP-2669266-B1 | Improved Method for Manufacturing Dipeptidyl Peptidase-IV Inhibitor and Intermediate | DONG A ST CO LTD (KR) | 2016-02-24 | — | — | EP | disclosed |
| EP-2669266-B1 | Improved Method for Manufacturing Dipeptidyl Peptidase-IV Inhibitor and Intermediate | DONG A ST CO LTD (KR) | 2016-02-24 | — | — | EP | disclosed |
| US-9249109-B2 | Method for preparing dipeptidyl peptidase-IV inhibitor and intermediate | DONG-A PHARMACEUTICAL CO., LTD. (KR) | 2016-02-02 | — | — | US | disclosed |
| US-9249109-B2 | Method for preparing dipeptidyl peptidase-IV inhibitor and intermediate | DONG-A PHARMACEUTICAL CO., LTD. (KR) | 2016-02-02 | — | — | US | disclosed |
| US-9249109-B2 | Method for preparing dipeptidyl peptidase-IV inhibitor and intermediate | DONG-A PHARMACEUTICAL CO., LTD. (KR) | 2016-02-02 | — | — | US | disclosed |
| US-9233967-B2 | Process for the preparation of sitagliptin and intermediate compounds | CIPLA LIMITED (IN) | 2016-01-12 | — | — | US | disclosed |
| US-9233967-B2 | Process for the preparation of sitagliptin and intermediate compounds | CIPLA LIMITED (IN) | 2016-01-12 | — | — | US | disclosed |
| US-20150359793-A1 | BETA-AMINO HETEROCYCLIC DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES | MERCK SHARP & DOHME (US) | 2015-12-17 | — | — | US | disclosed |
| US-20150359793-A1 | BETA-AMINO HETEROCYCLIC DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES | MERCK SHARP & DOHME (US) | 2015-12-17 | — | — | US | disclosed |
| US-20150359793-A1 | BETA-AMINO HETEROCYCLIC DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES | MERCK SHARP & DOHME (US) | 2015-12-17 | — | — | US | disclosed |
| US-9187419-B2 | Intermediates of sitagliptin and preparation process thereof | ZHEJIANG HISOAR PHARMACEUTICAL CO., LTD. (CN) | 2015-11-17 | — | — | US | disclosed |
| US-9187419-B2 | Intermediates of sitagliptin and preparation process thereof | ZHEJIANG HISOAR PHARMACEUTICAL CO., LTD. (CN) | 2015-11-17 | — | — | US | disclosed |
| US-9181260-B2 | Crystalline form of sitagliptin sulfate | MOEHS IBERICA, S.L. (ES) | 2015-11-10 | — | — | US | disclosed |
| US-9181260-B2 | Crystalline form of sitagliptin sulfate | MOEHS IBERICA, S.L. (ES) | 2015-11-10 | — | — | US | disclosed |
| US-9181260-B2 | Crystalline form of sitagliptin sulfate | MOEHS IBERICA, S.L. (ES) | 2015-11-10 | — | — | US | disclosed |
| WO-2015162506-A1 | PROCESS FOR THE PREPARATION OF SITAGLIPTIN AND NOVEL INTERMEDIATES | SUVEN LIFE SCIENCES LIMITED (IN) | 2015-10-29 | — | — | WO | disclosed |
| WO-2015162506-A1 | PROCESS FOR THE PREPARATION OF SITAGLIPTIN AND NOVEL INTERMEDIATES | SUVEN LIFE SCIENCES LIMITED (IN) | 2015-10-29 | — | — | WO | disclosed |
| WO-2015145333-A1 | PROCESS FOR THE PREPARATION OF SITAGLIPTIN AND ITS INTERMEDIATE | SUN PHARMACEUTICAL INDUSTRIES LIMITED (IN) | 2015-10-01 | — | — | WO | disclosed |
| WO-2015145333-A1 | PROCESS FOR THE PREPARATION OF SITAGLIPTIN AND ITS INTERMEDIATE | SUN PHARMACEUTICAL INDUSTRIES LIMITED (IN) | 2015-10-01 | — | — | WO | disclosed |
| CN-102260265-B | Hexahydropyrrolo [3,4-b] pyrrole derivative, Its Preparation Method And Use | SHANGHAI SUN-SAIL PHARMACEUTICAL SCIENCE & TECHNOLOGY CO., LTD. (CN) | 2015-09-02 | — | — | CN | disclosed |
| CN-103772323-B | DPP-4 inhibitor compound | NANJING HUAWE MEDICAL SCIENCE & TECHNOLOGY DEVELOPMENT CO., LTD. (CN) | 2015-08-05 | — | — | CN | disclosed |
| EP-2665728-B1 | PREPARATION METHOD OF INTERMEDIATE OF SITAGLIPTIN | ST PHARM CO LTD (KR) | 2015-07-22 | — | — | EP | disclosed |
| US-20150197523-A1 | PROCESS FOR THE PREPARATION OF SITAGLIPTIN AND INTERMEDIATE COMPOUNDS | CIPLA LIMITED (IN) | 2015-07-16 | — | — | US | disclosed |
| US-20150197523-A1 | PROCESS FOR THE PREPARATION OF SITAGLIPTIN AND INTERMEDIATE COMPOUNDS | CIPLA LIMITED (IN) | 2015-07-16 | — | — | US | disclosed |
| US-20150148533-A1 | New Synthetic Route For The Preparation Of Beta-aminobutyryl Substituted 5,6,7,8-tetrahydro[1,4]diazolo[4,3-alpha]Pyrazin-7-yl Compounds | LEK PHARMACEUTICALS D.D. (SI) | 2015-05-28 | — | — | US | disclosed |
| US-20150148533-A1 | New Synthetic Route For The Preparation Of Beta-aminobutyryl Substituted 5,6,7,8-tetrahydro[1,4]diazolo[4,3-alpha]Pyrazin-7-yl Compounds | LEK PHARMACEUTICALS D.D. (SI) | 2015-05-28 | — | — | US | disclosed |
| US-9006436-B2 | Preparation method of intermediate of sitagliptin | ST PHARM CO., LTD. (KR) | 2015-04-14 | — | — | US | disclosed |
| US-9006436-B2 | Preparation method of intermediate of sitagliptin | ST PHARM CO., LTD. (KR) | 2015-04-14 | — | — | US | disclosed |
| US-9006436-B2 | Preparation method of intermediate of sitagliptin | ST PHARM CO., LTD. (KR) | 2015-04-14 | — | — | US | disclosed |
| US-20150087834-A1 | PROCESS FOR THE PREPARATION OF SITAGLIPTIN PHOSPHATE | CADILA HEALTHCARE LIMITED (IN) | 2015-03-26 | — | — | US | disclosed |
| US-20150087834-A1 | PROCESS FOR THE PREPARATION OF SITAGLIPTIN PHOSPHATE | CADILA HEALTHCARE LIMITED (IN) | 2015-03-26 | — | — | US | disclosed |
| US-20150087834-A1 | PROCESS FOR THE PREPARATION OF SITAGLIPTIN PHOSPHATE | CADILA HEALTHCARE LIMITED (IN) | 2015-03-26 | — | — | US | disclosed |
| US-20150037406-A1 | NOVEL CRYSTALLINE FORM OF SITAGLIPTIN SULFATE | MOEHS IBERICA S.L. (ES) | 2015-02-05 | — | — | US | disclosed |
| US-20150037406-A1 | NOVEL CRYSTALLINE FORM OF SITAGLIPTIN SULFATE | MOEHS IBERICA S.L. (ES) | 2015-02-05 | — | — | US | disclosed |
| US-20150037406-A1 | NOVEL CRYSTALLINE FORM OF SITAGLIPTIN SULFATE | MOEHS IBERICA S.L. (ES) | 2015-02-05 | — | — | US | disclosed |
| US-20150025241-A1 | METHOD FOR PREPARING DIPEPTIDYL PEPTIDASE-IV INHIBITOR AND INTERMEDIATE | DONG-A PHARMACEUTICAL. CO., LTD (KR) | 2015-01-22 | — | — | US | disclosed |
| US-20150025241-A1 | METHOD FOR PREPARING DIPEPTIDYL PEPTIDASE-IV INHIBITOR AND INTERMEDIATE | DONG-A PHARMACEUTICAL. CO., LTD (KR) | 2015-01-22 | — | — | US | disclosed |
| US-20150025241-A1 | METHOD FOR PREPARING DIPEPTIDYL PEPTIDASE-IV INHIBITOR AND INTERMEDIATE | DONG-A PHARMACEUTICAL. CO., LTD (KR) | 2015-01-22 | — | — | US | disclosed |
| EP-2230241-B1 | TETRAHYDRO-IMIDAZO[1,5-A]PYRAZINE DERIVATIVES, PREPARATION METHODS AND MEDICAL USES THEREOF | JIANGSU HENGRUI MEDICINE CO (CN) | 2014-11-26 | — | — | EP | disclosed |
| EP-2250157-B1 | NOVEL HETEROCYCLIC COMPOUNDS | PANACEA BIOTEC LTD (IN) | 2014-11-05 | — | — | EP | disclosed |
| US-8846916-B2 | Sitagliptin synthesis | GENERICS [UK] LIMITED (GB) | 2014-09-30 | — | — | US | disclosed |
| EP-2142519-B1 | DPP-IV INHIBITOR INCLUDING BETA-AMINO GROUP, PREPARATION METHOD THEREOF AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME FOR PREVENTING AND TREATING A DIABETES OR AN OBESITY | DONG A PHARM CO LTD (KR) | 2014-09-24 | — | — | EP | disclosed |
| EP-2481722-B1 | SITAGLIPTIN INTERMEDIATES, PREPARATION METHODS AND USES THEREOF | ZHEJIANG JIUZHOU PHARM CO LTD (CN) | 2014-08-27 | — | — | EP | disclosed |
| EP-2481722-B1 | SITAGLIPTIN INTERMEDIATES, PREPARATION METHODS AND USES THEREOF | ZHEJIANG JIUZHOU PHARM CO LTD (CN) | 2014-08-27 | — | — | EP | disclosed |
| EP-2415753-B1 | METHOD FOR PREPARING DIPEPTIDYL PEPTIDASE-IV INHIBITOR AND INTERMEDIATE | DONG A PHARM CO LTD (KR) | 2014-08-27 | — | — | EP | disclosed |
| EP-2292232-B1 | BETA-AMINO TETRAHYDROIMIDAZO(1,2-A)PYRAZINES AND TETRAHYDROTRIAZOLO(4,3-A)PYRAZINES FOR USE IN THE TREATMENT OF DIABETES TYPE II | MERCK SHARP & DOHME (US) | 2014-08-20 | — | — | EP | disclosed |
| EP-2292232-B1 | BETA-AMINO TETRAHYDROIMIDAZO(1,2-A)PYRAZINES AND TETRAHYDROTRIAZOLO(4,3-A)PYRAZINES FOR USE IN THE TREATMENT OF DIABETES TYPE II | MERCK SHARP & DOHME (US) | 2014-08-20 | — | — | EP | disclosed |
| CN-102378751-B | Improved process for preparing dipeptidyl peptidase-IV inhibitors and intermediates | DONG A PHARM CO LTD | 2014-08-20 | — | — | CN | disclosed |
| US-8785477-B2 | Hexahydropyrrolo[3,4-b]pyrrole derivatives, preparation methods and pharmaceutical uses thereof | SHANGHAI SUN-SAIL PHARMACEUTICAL SCIENCE & TECHNOLOGY CO., LTD. (CN) | 2014-07-22 | — | — | US | disclosed |
| US-8785477-B2 | Hexahydropyrrolo[3,4-b]pyrrole derivatives, preparation methods and pharmaceutical uses thereof | SHANGHAI SUN-SAIL PHARMACEUTICAL SCIENCE & TECHNOLOGY CO., LTD. (CN) | 2014-07-22 | — | — | US | disclosed |
| US-8785477-B2 | Hexahydropyrrolo[3,4-b]pyrrole derivatives, preparation methods and pharmaceutical uses thereof | SHANGHAI SUN-SAIL PHARMACEUTICAL SCIENCE & TECHNOLOGY CO., LTD. (CN) | 2014-07-22 | — | — | US | disclosed |
| CN-103922971-A | Improved Method For Preparing Intermediate Of Dipeptidyl Peptidase-iv Inhibitor | DONG A PHARM CO LTD | 2014-07-16 | — | — | CN | disclosed |
| EP-2578586-B1 | HEXAHYDROPYRROLO[3,4-b]PYRROLE DERIVATIVES, PREPARATION METHODS AND PHARMACEUTICAL USES THEREOF | SHANGHAI SUN SAIL PHARMACEUTICAL SCIENCE & TECHNOLOGY CO LTD (CN) | 2014-07-09 | — | — | EP | disclosed |
| EP-2578586-B1 | HEXAHYDROPYRROLO[3,4-b]PYRROLE DERIVATIVES, PREPARATION METHODS AND PHARMACEUTICAL USES THEREOF | SHANGHAI SUN SAIL PHARMACEUTICAL SCIENCE & TECHNOLOGY CO LTD (CN) | 2014-07-09 | — | — | EP | disclosed |
| US-8765668-B2 | Methods of synthesis of β-aminobutyryl substituted compounds | LEK PHARMACEUTICALS D.D. (SI) | 2014-07-01 | — | — | US | disclosed |
| US-8765668-B2 | Methods of synthesis of β-aminobutyryl substituted compounds | LEK PHARMACEUTICALS D.D. (SI) | 2014-07-01 | — | — | US | disclosed |
| WO-2014086325-A1 | A METHOD OF PREPARING 3-AMINO-4-(2,4,5-TRIFLUOROPHENYL)BUTANOIC ACID DERIVATIVES | ZENTIVA, K.S. (CZ) | 2014-06-12 | — | — | WO | disclosed |
| EP-2736909-A1 | PROCESS FOR THE PREPARATION OF SITAGLIPTIN AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS | Farma GRS, d.o.o. (SI) | 2014-06-04 | — | — | EP | disclosed |
| CN-103772323-A | DPP-4 (Dipepitidyl Peptidase-4) inhibitor compound | NANJING HUAWE MEDICAL TECHNOLOGY DEV CO LTD | 2014-05-07 | — | — | CN | disclosed |
| CN-101925586-B | Novel heterocyclic compounds | PANACEA BIOTEC LTD | 2014-05-07 | — | — | CN | disclosed |
| US-8710255-B2 | Sitagliptin intermediate compounds, preparation methods and uses thereof | ZHEJIANG JIUZHOU PHARMACEUTICAL CO., LTD. (CN) | 2014-04-29 | — | — | US | disclosed |
| US-8624026-B2 | Method of preparing sitagliptin and intermediates used therein | HANMI SCIENCE CO., LTD (KR) | 2014-01-07 | — | — | US | disclosed |
| US-8624026-B2 | Method of preparing sitagliptin and intermediates used therein | HANMI SCIENCE CO., LTD (KR) | 2014-01-07 | — | — | US | disclosed |
| US-20140005394-A1 | PREPARATION METHOD OF INTERMEDIATE OF SITAGLIPTIN | ST PHARM CO., LTD (KR) | 2014-01-02 | — | — | US | disclosed |
| EP-2669265-A2 | Improved method for preparing dipeptidyl peptidase-IV inhibitor and intermediate | Dong-A Pharmaceutical Co., Ltd. (KR) | 2013-12-04 | — | — | EP | disclosed |
| EP-2669266-A1 | Improved Method for Manufacturing Dipeptidyl Peptidase-IV Inhibitor and Intermediate | Dong-A Pharmaceutical Co., Ltd. (KR) | 2013-12-04 | — | — | EP | disclosed |
| US-8598347-B2 | Method for manufacturing dipeptidyl peptidase-IV inhibitor and intermediate | DONG-A PHARMACEUTICAL. CO., LTD (KR) | 2013-12-03 | — | — | US | disclosed |
| EP-2665728-A2 | PREPARATION METHOD OF INTERMEDIATE OF SITAGLIPTIN | ST Pharm Co. Ltd. (KR) | 2013-11-27 | — | — | EP | disclosed |
| US-20130281695-A1 | INTERMEDIATES OF SITAGLIPTIN AND PREPARATION PROCESS THEREOF | ZHEJIANG HISOAR PHARMACEUTICAL CO., LTD. (CN) | 2013-10-24 | — | — | US | disclosed |
| US-20130281695-A1 | INTERMEDIATES OF SITAGLIPTIN AND PREPARATION PROCESS THEREOF | ZHEJIANG HISOAR PHARMACEUTICAL CO., LTD. (CN) | 2013-10-24 | — | — | US | disclosed |
| EP-2647624-A1 | INTERMEDIATES OF SITAGLIPTIN AND PREPARATION PROCESS THEREOF | Zhejiang Hisoar Pharmaceutical Co., Ltd (CN) | 2013-10-09 | — | — | EP | disclosed |
| WO-2013128000-A1 | NOVEL CRYSTALLINE FORM OF SITAGLIPTIN SULFATE | MOEHS IBERICA S.L. (ES) | 2013-09-06 | — | — | WO | disclosed |
| US-8518946-B2 | Salts of (R)-7-[3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-trifluoromethyl-5,6,7,8-tetrahydroimidazo[1,5-a] pyrazine-1-carboxylic acid, preparation method and medical use thereof | JIANGSU HENGRUI MEDICINE CO., LTD. (CN) | 2013-08-27 | — | — | US | disclosed |
| US-8518946-B2 | Salts of (R)-7-[3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-trifluoromethyl-5,6,7,8-tetrahydroimidazo[1,5-a] pyrazine-1-carboxylic acid, preparation method and medical use thereof | JIANGSU HENGRUI MEDICINE CO., LTD. (CN) | 2013-08-27 | — | — | US | disclosed |
| US-8518946-B2 | Salts of (R)-7-[3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-trifluoromethyl-5,6,7,8-tetrahydroimidazo[1,5-a] pyrazine-1-carboxylic acid, preparation method and medical use thereof | JIANGSU HENGRUI MEDICINE CO., LTD. (CN) | 2013-08-27 | — | — | US | disclosed |
| US-20130217695-A1 | BETA-AMINO HETEROCYCLIC DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES | MERCK SHARP & DOHME CORP. (US) | 2013-08-22 | — | — | US | disclosed |
| US-20130217695-A1 | BETA-AMINO HETEROCYCLIC DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES | MERCK SHARP & DOHME CORP. (US) | 2013-08-22 | — | — | US | disclosed |
| US-20130217695-A1 | BETA-AMINO HETEROCYCLIC DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES | MERCK SHARP & DOHME CORP. (US) | 2013-08-22 | — | — | US | disclosed |
| US-8513411-B2 | Tetrahydro-imidazo[1,5-α] pyrazine derivatives, preparation process and medicinal use thereof | JIANGSU HENGRUI MEDICINE CO., LTD. (CN) | 2013-08-20 | — | — | US | disclosed |
| US-8513411-B2 | Tetrahydro-imidazo[1,5-α] pyrazine derivatives, preparation process and medicinal use thereof | JIANGSU HENGRUI MEDICINE CO., LTD. (CN) | 2013-08-20 | — | — | US | disclosed |
| US-8513411-B2 | Tetrahydro-imidazo[1,5-α] pyrazine derivatives, preparation process and medicinal use thereof | JIANGSU HENGRUI MEDICINE CO., LTD. (CN) | 2013-08-20 | — | — | US | disclosed |
| WO-2013114173-A1 | A NOVEL PROCESS FOR THE PREPARATION OF SITAGLIPTIN | SMILAX LABORATORIES LIMITED (IN) | 2013-08-08 | — | — | WO | disclosed |
| US-20130178500-A1 | HEXAHYDROPYRROLO[3,4-b]PYRROLE DERIVATIVES, PREPARATION METHODS AND PHARMACEUTICAL USES THEREOF | JIANGSU JINGLIXIN PHARMACEUTICAL TECHNOLOGY CO.,LTD. (CN) | 2013-07-11 | — | — | US | disclosed |
| US-20130178500-A1 | HEXAHYDROPYRROLO[3,4-b]PYRROLE DERIVATIVES, PREPARATION METHODS AND PHARMACEUTICAL USES THEREOF | JIANGSU JINGLIXIN PHARMACEUTICAL TECHNOLOGY CO.,LTD. (CN) | 2013-07-11 | — | — | US | disclosed |
| US-20130178500-A1 | HEXAHYDROPYRROLO[3,4-b]PYRROLE DERIVATIVES, PREPARATION METHODS AND PHARMACEUTICAL USES THEREOF | JIANGSU JINGLIXIN PHARMACEUTICAL TECHNOLOGY CO.,LTD. (CN) | 2013-07-11 | — | — | US | disclosed |
| US-8471057-B2 | Sitagliptin intermediates, preparation methods and uses thereof | ZHEJIANG JIUZHOU PHARMACEUTICAL CO., LTD. (CN) | 2013-06-25 | — | — | US | disclosed |
| US-8471057-B2 | Sitagliptin intermediates, preparation methods and uses thereof | ZHEJIANG JIUZHOU PHARMACEUTICAL CO., LTD. (CN) | 2013-06-25 | — | — | US | disclosed |
| US-8471057-B2 | Sitagliptin intermediates, preparation methods and uses thereof | ZHEJIANG JIUZHOU PHARMACEUTICAL CO., LTD. (CN) | 2013-06-25 | — | — | US | disclosed |
| US-8455479-B2 | Heterocyclic compounds | PANACEA BIOTEC LIMITED (IN) | 2013-06-04 | — | — | US | disclosed |
| US-20130137852-A1 | NOVEL COMPOUNDS AS DPP-IV INHIBITORS AND PROCESS FOR PREPARATION THEREOF | Cadila Corporate Campus (IN) | 2013-05-30 | — | — | US | disclosed |
| US-20130137852-A1 | NOVEL COMPOUNDS AS DPP-IV INHIBITORS AND PROCESS FOR PREPARATION THEREOF | Cadila Corporate Campus (IN) | 2013-05-30 | — | — | US | disclosed |
| US-20130130974-A1 | NOVEL SYNTHETIC APPROACH TO beta-AMINOBUTYRYL SUBSTITUTED COMPOUNDS | LEK PHARMACEUTICALS D.D. (SI) | 2013-05-23 | — | — | US | disclosed |
| US-20130130974-A1 | NOVEL SYNTHETIC APPROACH TO beta-AMINOBUTYRYL SUBSTITUTED COMPOUNDS | LEK PHARMACEUTICALS D.D. (SI) | 2013-05-23 | — | — | US | disclosed |
| US-8440669-B2 | Pharmaceutical composition for prevention and treatment of diabetes or obesity comprising a compound that inhibits activity of dipeptidyl peptidase-IV, and other antidiabetic or antiobesity agents as active ingredients | DONG-A PHARMACEUTICAL CO. LTD. (KR) | 2013-05-14 | — | — | US | disclosed |
| US-8440668-B2 | Beta-amino heterocyclic dipeptidyl peptidase inhibitors for the treatment of type 2 diabetes | MERCK SHARP & DOHME CORP (US) | 2013-05-14 | — | — | US | disclosed |
| US-8440668-B2 | Beta-amino heterocyclic dipeptidyl peptidase inhibitors for the treatment of type 2 diabetes | MERCK SHARP & DOHME CORP (US) | 2013-05-14 | — | — | US | disclosed |
| US-8440668-B2 | Beta-amino heterocyclic dipeptidyl peptidase inhibitors for the treatment of type 2 diabetes | MERCK SHARP & DOHME CORP (US) | 2013-05-14 | — | — | US | disclosed |
| CN-103058888-A | Preparation method of (R)-3-t-butyloxycarboryl-amino-4-(2, 4, 5-trifluorobenzene) butyric acid | SHANGHAI PUYI CHEMICAL CO LTD | 2013-04-24 | — | — | CN | disclosed |
| CN-103058888-A | Preparation method of (R)-3-t-butyloxycarboryl-amino-4-(2, 4, 5-trifluorobenzene) butyric acid | SHANGHAI PUYI CHEMICAL CO LTD | 2013-04-24 | — | — | CN | disclosed |
| EP-2578586-A1 | HEXAHYDROPYRROLO[3,4-b]PYRROLE DERIVATIVES, PREPARATION METHODS AND PHARMACEUTICAL USES THEREOF | Shanghai Sun-Sail Pharmaceutical Science & Technology Co., Ltd (CN) | 2013-04-10 | — | — | EP | disclosed |
| EP-2578586-A1 | HEXAHYDROPYRROLO[3,4-b]PYRROLE DERIVATIVES, PREPARATION METHODS AND PHARMACEUTICAL USES THEREOF | Shanghai Sun-Sail Pharmaceutical Science & Technology Co., Ltd (CN) | 2013-04-10 | — | — | EP | disclosed |
| WO-2013013833-A1 | PROCESS FOR THE PREPARATION OF SITAGLIPTIN AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS | FARMA GRS, D.O.O. (SI) | 2013-01-31 | — | — | WO | disclosed |
| EP-2551259-A1 | SITAGLIPTIN INTERMEDIATE COMPOUNDS, PREPARATION METHODS AND USES THEREOF | Zhejiang Jiuzhou Pharmaceutical Co., Ltd. (CN) | 2013-01-30 | — | — | EP | disclosed |
| EP-2551259-A1 | SITAGLIPTIN INTERMEDIATE COMPOUNDS, PREPARATION METHODS AND USES THEREOF | Zhejiang Jiuzhou Pharmaceutical Co., Ltd. (CN) | 2013-01-30 | — | — | EP | disclosed |
| US-20130012735-A1 | SITAGLIPTIN INTERMEDIATE COMPOUNDS, PREPARATION METHODS AND USES THEREOF | ZHEJIANG JIUZHOU PHARMACEAUTICAL CO., LTD. (CN) | 2013-01-10 | — | — | US | disclosed |
| US-20130012735-A1 | SITAGLIPTIN INTERMEDIATE COMPOUNDS, PREPARATION METHODS AND USES THEREOF | ZHEJIANG JIUZHOU PHARMACEAUTICAL CO., LTD. (CN) | 2013-01-10 | — | — | US | disclosed |
| US-20130012735-A1 | SITAGLIPTIN INTERMEDIATE COMPOUNDS, PREPARATION METHODS AND USES THEREOF | ZHEJIANG JIUZHOU PHARMACEAUTICAL CO., LTD. (CN) | 2013-01-10 | — | — | US | disclosed |
| US-8334385-B2 | Process for the preparation of R-sitagliptin and its pharmaceutically acceptable salts thereof | GLENMARK GENERICS LIMITED | 2012-12-18 | — | — | US | disclosed |
| US-8278486-B2 | Process and intermediates for the preparation of N-acylated-4-aryl beta-amino acid derivatives | CHIRAL QUEST, INC. (US) | 2012-10-02 | — | — | US | disclosed |
| US-8278486-B2 | Process and intermediates for the preparation of N-acylated-4-aryl beta-amino acid derivatives | CHIRAL QUEST, INC. (US) | 2012-10-02 | — | — | US | disclosed |
| US-8278486-B2 | Process and intermediates for the preparation of N-acylated-4-aryl beta-amino acid derivatives | CHIRAL QUEST, INC. (US) | 2012-10-02 | — | — | US | disclosed |
| US-20120220766-A1 | TETRAHYDRO-IMIDAZO[1,5-alpha] PYRAZINE DERIVATIVES, PREPERATION PROCESS AND MEDICINAL USE THEREOF | SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD. (CN) | 2012-08-30 | — | — | US | disclosed |
| US-20120220766-A1 | TETRAHYDRO-IMIDAZO[1,5-alpha] PYRAZINE DERIVATIVES, PREPERATION PROCESS AND MEDICINAL USE THEREOF | SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD. (CN) | 2012-08-30 | — | — | US | disclosed |
| US-20120220766-A1 | TETRAHYDRO-IMIDAZO[1,5-alpha] PYRAZINE DERIVATIVES, PREPERATION PROCESS AND MEDICINAL USE THEREOF | SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD. (CN) | 2012-08-30 | — | — | US | disclosed |
| US-20120214997-A1 | METHOD OF PREPARING SITAGLIPTIN AND INTERMEDIATES USED THEREIN | HANMI HOLDINGS CO., LTD. (KR) | 2012-08-23 | — | — | US | disclosed |
| US-20120214997-A1 | METHOD OF PREPARING SITAGLIPTIN AND INTERMEDIATES USED THEREIN | HANMI HOLDINGS CO., LTD. (KR) | 2012-08-23 | — | — | US | disclosed |
| EP-2481722-A1 | SITAGLIPTIN INTERMEDIATES, PREPARATION METHODS AND USES THEREOF | Zhejiang Jiuzhou Pharmaceutical Co., Ltd. (CN) | 2012-08-01 | — | — | EP | disclosed |
| EP-2481722-A1 | SITAGLIPTIN INTERMEDIATES, PREPARATION METHODS AND USES THEREOF | Zhejiang Jiuzhou Pharmaceutical Co., Ltd. (CN) | 2012-08-01 | — | — | EP | disclosed |
| WO-2012099381-A2 | PREPARATION METHOD OF INTERMEDIATE OF SITAGLIPTIN | ST PHARM CO., LTD. (KR) | 2012-07-26 | — | — | WO | disclosed |
| CN-102603749-A | Synthesis method of sitagliptin intermediate | ZHEJIANG HUAHAI PHARM CO LTD | 2012-07-25 | — | — | CN | disclosed |
| US-20120178957-A1 | SITAGLIPTIN INTERMEDIATES, PREPARATION METHODS AND USES THEREOF | ZHEJIANG JIUZHOU PHARMACEUTICAL CO., LTD. (CN) | 2012-07-12 | — | — | US | disclosed |
| US-20120178957-A1 | SITAGLIPTIN INTERMEDIATES, PREPARATION METHODS AND USES THEREOF | ZHEJIANG JIUZHOU PHARMACEUTICAL CO., LTD. (CN) | 2012-07-12 | — | — | US | disclosed |
| US-20120178957-A1 | SITAGLIPTIN INTERMEDIATES, PREPARATION METHODS AND USES THEREOF | ZHEJIANG JIUZHOU PHARMACEUTICAL CO., LTD. (CN) | 2012-07-12 | — | — | US | disclosed |
| US-8207161-B2 | Tetrahydro-imidazo[1,5-α]pyrazine derivatives, preparation process and medicinal use thereof | JIANGSU HENGRUI MEDICINE CO. LTD. (CN) | 2012-06-26 | — | — | US | disclosed |
| US-8207161-B2 | Tetrahydro-imidazo[1,5-α]pyrazine derivatives, preparation process and medicinal use thereof | JIANGSU HENGRUI MEDICINE CO. LTD. (CN) | 2012-06-26 | — | — | US | disclosed |
| US-8207161-B2 | Tetrahydro-imidazo[1,5-α]pyrazine derivatives, preparation process and medicinal use thereof | JIANGSU HENGRUI MEDICINE CO. LTD. (CN) | 2012-06-26 | — | — | US | disclosed |
| US-20120108598-A1 | SITAGLIPTIN SYNTHESIS | MYLAN INDIA PRIVATE LIMITED (IN) | 2012-05-03 | — | — | US | disclosed |
| US-8168637-B2 | Beta-amino heterocyclic dipeptidyl peptidase inhibitors for the treatment of diabetes | MERCK SHARP & DOHME CORP. (US) | 2012-05-01 | — | — | US | disclosed |
| US-8168637-B2 | Beta-amino heterocyclic dipeptidyl peptidase inhibitors for the treatment of diabetes | MERCK SHARP & DOHME CORP. (US) | 2012-05-01 | — | — | US | disclosed |
| US-8168637-B2 | Beta-amino heterocyclic dipeptidyl peptidase inhibitors for the treatment of diabetes | MERCK SHARP & DOHME CORP. (US) | 2012-05-01 | — | — | US | disclosed |
| WO-2012035549-A2 | AN IMPROVED PROCESS FOR THE SYNTHESIS OF BETA AMINO ACID DERIVATIVES | PANACEA BIOTEC LTD (IN) | 2012-03-22 | — | — | WO | disclosed |
| EP-2430025-A1 | SITAGLIPTIN SYNTHESIS | Generics [UK] Limited (GB) | 2012-03-21 | — | — | EP | disclosed |
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |
| US-20120065209-A1 | TETRAHYDRO-IMIDAZO[1,5-a]PYRAZINE DERIVATIVES SALTS, PREPARATION METHODS AND MEDICINAL USE THEREOF | SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD. (CN) | 2012-03-15 | — | — | US | disclosed |
| US-20120065209-A1 | TETRAHYDRO-IMIDAZO[1,5-a]PYRAZINE DERIVATIVES SALTS, PREPARATION METHODS AND MEDICINAL USE THEREOF | SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD. (CN) | 2012-03-15 | — | — | US | disclosed |
| EP-2423178-A1 | Process for the production of sitagliptin | Chemo Ibérica, S.A. (ES) | 2012-02-29 | — | — | EP | disclosed |
| EP-2423178-A1 | Process for the production of sitagliptin | Chemo Ibérica, S.A. (ES) | 2012-02-29 | — | — | EP | disclosed |
| WO-2012017391-A2 | NOVEL COMPOUNDS AS DPP-IV INHIBITORS AND PROCESS FOR PREPARATION THEREOF | CADILA PHARMACEUTICALS LIMITED (IN) | 2012-02-09 | — | — | WO | disclosed |
| EP-2415754-A2 | IMPROVED METHOD FOR MANUFACTURING DIPEPTIDYL PEPTIDASE-IV INHIBITOR AND INTERMEDIATE | Dong-A Pharmaceutical Co., Ltd. (KR) | 2012-02-08 | — | — | EP | disclosed |
| EP-2415754-A2 | IMPROVED METHOD FOR MANUFACTURING DIPEPTIDYL PEPTIDASE-IV INHIBITOR AND INTERMEDIATE | Dong-A Pharmaceutical Co., Ltd. (KR) | 2012-02-08 | — | — | EP | disclosed |
| EP-2415753-A2 | IMPROVED METHOD FOR PREPARING DIPEPTIDYL PEPTIDASE-IV INHIBITOR AND INTERMEDIATE | Dong-A Pharmaceutical Co., Ltd. (KR) | 2012-02-08 | — | — | EP | disclosed |
| EP-2415753-A2 | IMPROVED METHOD FOR PREPARING DIPEPTIDYL PEPTIDASE-IV INHIBITOR AND INTERMEDIATE | Dong-A Pharmaceutical Co., Ltd. (KR) | 2012-02-08 | — | — | EP | disclosed |
| US-20120016126-A1 | METHOD FOR MANUFACTURING DIPEPTIDYL PEPTIDASE-IV INHIBITOR AND INTERMEDIATE | DONG-A PHARMACEUTICAL. CO., LTD (KR) | 2012-01-19 | — | — | US | disclosed |
| US-20120016126-A1 | METHOD FOR MANUFACTURING DIPEPTIDYL PEPTIDASE-IV INHIBITOR AND INTERMEDIATE | DONG-A PHARMACEUTICAL. CO., LTD (KR) | 2012-01-19 | — | — | US | disclosed |
| US-20120016126-A1 | METHOD FOR MANUFACTURING DIPEPTIDYL PEPTIDASE-IV INHIBITOR AND INTERMEDIATE | DONG-A PHARMACEUTICAL. CO., LTD (KR) | 2012-01-19 | — | — | US | disclosed |
| US-20120016125-A1 | METHOD FOR PREPARING DIPEPTIDYL PEPTIDASE-IV INHIBITOR AND INTERMEDIATE | DONG-A PHARMACEUTICAL. CO., LTD (KR) | 2012-01-19 | — | — | US | disclosed |
| US-20120016125-A1 | METHOD FOR PREPARING DIPEPTIDYL PEPTIDASE-IV INHIBITOR AND INTERMEDIATE | DONG-A PHARMACEUTICAL. CO., LTD (KR) | 2012-01-19 | — | — | US | disclosed |
| EP-2404921-A1 | SALTS OF TETRAHYDROIMIDAZO Ý1,5-A¨PYRAZINE DERIVATIVES, PREPARATION METHODS AND PHARMACEUTICAL USE THEREOF | Jiangsu Hengrui Medicine Co., Ltd. (CN) | 2012-01-11 | — | — | EP | disclosed |
| WO-2011151443-A1 | A NOVEL SYNTHETIC APPROACH TO ß-AMINOBUTYRYL SUBSTITUTED COMPOUNDS | LEK PHARMACEUTICALS D.D. (SI) | 2011-12-08 | — | — | WO | disclosed |
| WO-2011147207-A1 | HEXAHYDROPYRROLO[3,4-b]PYRROLE DERIVATIVES, PREPARATION METHODS AND PHARMACEUTICAL USES THEREOF | 上海阳帆医药科技有限公司 (CN) | 2011-12-01 | — | — | WO | disclosed |
| US-8030315-B2 | DPP-IV inhibitor including beta-amino group, preparation method thereof and pharmaceutical composition containing the same for preventing and treating diabetes or obesity | DONG-A PHARM. CO., LTD. (KR) | 2011-10-04 | — | — | US | disclosed |
| US-8030315-B2 | DPP-IV inhibitor including beta-amino group, preparation method thereof and pharmaceutical composition containing the same for preventing and treating diabetes or obesity | DONG-A PHARM. CO., LTD. (KR) | 2011-10-04 | — | — | US | disclosed |
| US-8030315-B2 | DPP-IV inhibitor including beta-amino group, preparation method thereof and pharmaceutical composition containing the same for preventing and treating diabetes or obesity | DONG-A PHARM. CO., LTD. (KR) | 2011-10-04 | — | — | US | disclosed |
| US-20110201624-A1 | Pharmaceutical Composition for Prevention and Treatment of Diabetes or Obesity Comprising a Compound that Inhibits Activity of Dipeptidyl Peptidase-IV, and other Antidiabetic or Antiobesity Agents as Active Ingredients | DONG-A PHARMACEUTICAL. CO., LTD (KR) | 2011-08-18 | — | — | US | disclosed |
| US-20110190308-A1 | NOVEL CYCLIC AZABENZIMIDAZOLE DERIVATIVES USEFUL AS ANTI-DIABETIC AGENTS | MERCK SHARP & DOHME CORP. (US) | 2011-08-04 | — | — | US | disclosed |
| US-20110190308-A1 | NOVEL CYCLIC AZABENZIMIDAZOLE DERIVATIVES USEFUL AS ANTI-DIABETIC AGENTS | MERCK SHARP & DOHME CORP. (US) | 2011-08-04 | — | — | US | disclosed |
| US-20110190308-A1 | NOVEL CYCLIC AZABENZIMIDAZOLE DERIVATIVES USEFUL AS ANTI-DIABETIC AGENTS | MERCK SHARP & DOHME CORP. (US) | 2011-08-04 | — | — | US | disclosed |
| WO-2011092671-A1 | PROLINE DERIVATIVES FOR USE IN THE TREATMENT OF DIABETES | RANBAXY LABORATORIES LIMITED (IN) | 2011-08-04 | — | — | WO | disclosed |
| EP-2351567-A2 | PHARMACEUTICAL COMPOSITION FOR PREVENTION AND TREATMENT OF DIABETES OR OBESITY COMPRISING A COMPOUND THAT INHIBITS ACTIVITY OF DIPEPTIDYL PEPTIDASE-IV, AND OTHER ANTIDIABETIC OR ANTIOBESITY AGENTS AS ACTIVE INGREDIENTS | Dong-A Pharmaceutical Co., Ltd. (KR) | 2011-08-03 | — | — | EP | disclosed |
| WO-2011049344-A2 | METHOD OF PREPARING SITAGLIPTIN AND INTERMEDIATES USED THEREIN | HANMI HOLDINGS CO., LTD. (KR) | 2011-04-28 | — | — | WO | disclosed |
| EP-2292232-A1 | Beta-amino tetrahydroimidazo(1,2-A)pyrazines and tetrahydrotriazolo(4,3-A)pyrazines for use in the treatment of diabetes type II | Merck Sharp & Dohme Corp. (US) | 2011-03-09 | — | — | EP | disclosed |
| CN-101925586-A | Novel heterocyclic compounds | PANACEA BIOTEC LTD | 2010-12-22 | — | — | CN | disclosed |
| US-20100317856-A1 | PROCESS FOR THE PREPARATION OF R-SITAGLIPTIN AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF | GLENMARK GENERICS LTD (IN) | 2010-12-16 | — | — | US | disclosed |
| US-20100311732-A1 | NOVEL HETEROCYCLIC COMPOUNDS | PANACEA BIOTEC PHARMA LIMITED (IN) | 2010-12-09 | — | — | US | disclosed |
| WO-2010131025-A1 | SITAGLIPTIN SYNTHESIS | GENERICS [UK] LIMITED (GB) | 2010-11-18 | — | — | WO | disclosed |
| EP-2250157-A1 | NOVEL HETEROCYCLIC COMPOUNDS | Panacea Biotec Limited (IN) | 2010-11-17 | — | — | EP | disclosed |
| US-20100280245-A1 | PROCESS AND INTERMEDIATES FOR THE PREPARATION OF N-ACYLATED-4-ARYL BETA-AMINO ACID DERIVATIVES | CHIRAL QUEST, INC. | 2010-11-04 | — | — | US | disclosed |
| US-20100280245-A1 | PROCESS AND INTERMEDIATES FOR THE PREPARATION OF N-ACYLATED-4-ARYL BETA-AMINO ACID DERIVATIVES | CHIRAL QUEST, INC. | 2010-11-04 | — | — | US | disclosed |
| US-20100280245-A1 | PROCESS AND INTERMEDIATES FOR THE PREPARATION OF N-ACYLATED-4-ARYL BETA-AMINO ACID DERIVATIVES | CHIRAL QUEST, INC. | 2010-11-04 | — | — | US | disclosed |
| WO-2010122578-A2 | PROCESS FOR THE PREPARATION OF SITAGLIPTIN AND ITS INTERMEDIATES | MSN LABORATORIES LIMITED (IN) | 2010-10-28 | — | — | WO | disclosed |
| US-20100273786-A1 | TETRAHYDRO-IMIDAZ0[1,5-A]PYRAZINE DERIVATIVES, PREPARATION PROCESS AND MEDICINAL USE THEREOF | JIANGSU HENGRUI MEDICINE CO., LTD. (CN) | 2010-10-28 | — | — | US | disclosed |
| US-20100273786-A1 | TETRAHYDRO-IMIDAZ0[1,5-A]PYRAZINE DERIVATIVES, PREPARATION PROCESS AND MEDICINAL USE THEREOF | JIANGSU HENGRUI MEDICINE CO., LTD. (CN) | 2010-10-28 | — | — | US | disclosed |
| US-20100273786-A1 | TETRAHYDRO-IMIDAZ0[1,5-A]PYRAZINE DERIVATIVES, PREPARATION PROCESS AND MEDICINAL USE THEREOF | JIANGSU HENGRUI MEDICINE CO., LTD. (CN) | 2010-10-28 | — | — | US | disclosed |
| US-7820666-B2 | Tetrahydrotriazolopyrazine derivatives and uses thereof | CONCERT PHARMACEUTICALS, INC. (US) | 2010-10-26 | — | — | US | disclosed |
| US-7820666-B2 | Tetrahydrotriazolopyrazine derivatives and uses thereof | CONCERT PHARMACEUTICALS, INC. (US) | 2010-10-26 | — | — | US | disclosed |
| US-7820666-B2 | Tetrahydrotriazolopyrazine derivatives and uses thereof | CONCERT PHARMACEUTICALS, INC. (US) | 2010-10-26 | — | — | US | disclosed |
| WO-2010114291-A2 | IMPROVED METHOD FOR PREPARING DIPEPTIDYL PEPTIDASE-IV INHIBITOR AND INTERMEDIATE | 동아제약 주식회사 (KR) | 2010-10-07 | — | — | WO | disclosed |
| WO-2010114292-A2 | IMPROVED METHOD FOR MANUFACTURING DIPEPTIDYL PEPTIDASE-IV INHIBITOR AND INTERMEDIATE | 동아제약 주식회사 (KR) | 2010-10-07 | — | — | WO | disclosed |
| EP-2230241-A1 | TETRAHYDRO-IMIDAZOÝ1,5-A¨PYRAZINE DERIVATIVES, PREPARATION METHODS AND MEDICAL USES THEREOF | Jiangsu Hengrui Medicine Co., Ltd. (CN) | 2010-09-22 | — | — | EP | disclosed |
| EP-2230241-A1 | TETRAHYDRO-IMIDAZOÝ1,5-A¨PYRAZINE DERIVATIVES, PREPARATION METHODS AND MEDICAL USES THEREOF | Jiangsu Hengrui Medicine Co., Ltd. (CN) | 2010-09-22 | — | — | EP | disclosed |
| EP-2226324-A1 | BETA-AMINO TETRAHYDROIMIDAZO(1,2-A)PYRAZINES AND TETRAHYDROTRIAZOLO(4,3-A)PYRAZINES FOR USE IN THE TREATMENT OF DIABETES TYPE II | Merck Sharp & Dohme Corp. (US) | 2010-09-08 | — | — | EP | disclosed |
| EP-2226324-A1 | BETA-AMINO TETRAHYDROIMIDAZO(1,2-A)PYRAZINES AND TETRAHYDROTRIAZOLO(4,3-A)PYRAZINES FOR USE IN THE TREATMENT OF DIABETES TYPE II | Merck Sharp & Dohme Corp. (US) | 2010-09-08 | — | — | EP | disclosed |
| WO-2010097420-A1 | PROCESS FOR THE PREPARATION OF A CHIRAL BETA AMINOACID DERIVATIVE AND INTERMEDIATES THEREOF | Esteve Química, S.A. (ES) | 2010-09-02 | — | — | WO | disclosed |
| EP-1784188-B1 | FUSED TRIAZOLE DERIVATIVES AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES | MERCK SHARP & DOHME (US) | 2010-07-14 | — | — | EP | disclosed |
| EP-1784188-B1 | FUSED TRIAZOLE DERIVATIVES AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES | MERCK SHARP & DOHME (US) | 2010-07-14 | — | — | EP | disclosed |
| WO-2010078440-A1 | PROCESS AND INTERMEDIATES FOR THE PREPARATION OF N-ACYLATED-4-ARYL BETA-AMINO ACID DERIVATIVES | CHIRAL QUEST, INC. (US) | 2010-07-08 | — | — | WO | disclosed |
| EP-1625847-B1 | Medical use of a tetrahydrotriazolo[4,3-a]pyrazine | MERCK SHARP & DOHME (US) | 2010-06-16 | — | — | EP | disclosed |
| US-20100130504-A1 | BETA-AMINO HETEROCYCLIC DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES | MERCK SHARP & DOHME LLC | 2010-05-27 | — | — | US | disclosed |
| US-20100130504-A1 | BETA-AMINO HETEROCYCLIC DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES | MERCK SHARP & DOHME LLC | 2010-05-27 | — | — | US | disclosed |
| US-20100130504-A1 | BETA-AMINO HETEROCYCLIC DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES | MERCK SHARP & DOHME LLC | 2010-05-27 | — | — | US | disclosed |
| US-20100120790-A1 | DPP-IV INHIBITOR INCLUDING BETA-AMINO GROUP, PREPARATION METHOD THEREOF AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME FOR PREVENTING AND TREATING DIABETES OR OBESITY | DONG-A PHARM. CO., LTD (KR) | 2010-05-13 | — | — | US | disclosed |
| US-20100120790-A1 | DPP-IV INHIBITOR INCLUDING BETA-AMINO GROUP, PREPARATION METHOD THEREOF AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME FOR PREVENTING AND TREATING DIABETES OR OBESITY | DONG-A PHARM. CO., LTD (KR) | 2010-05-13 | — | — | US | disclosed |
| US-20100120790-A1 | DPP-IV INHIBITOR INCLUDING BETA-AMINO GROUP, PREPARATION METHOD THEREOF AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME FOR PREVENTING AND TREATING DIABETES OR OBESITY | DONG-A PHARM. CO., LTD (KR) | 2010-05-13 | — | — | US | disclosed |
| US-20100076024-A1 | Novel Compounds as Serine Protease Inhibitors | ZIMMERMANN KASPAR | 2010-03-25 | — | — | US | disclosed |
| US-20100076024-A1 | Novel Compounds as Serine Protease Inhibitors | ZIMMERMANN KASPAR | 2010-03-25 | — | — | US | disclosed |
| US-20100076024-A1 | Novel Compounds as Serine Protease Inhibitors | ZIMMERMANN KASPAR | 2010-03-25 | — | — | US | disclosed |
| US-20100048570-A1 | THIAZOLIDINE DERIVATIVES AND METHODS FOR THE PREPARATION THEREOF | Kainos Medicine, Inc (KR) | 2010-02-25 | — | — | US | disclosed |
| US-20100048570-A1 | THIAZOLIDINE DERIVATIVES AND METHODS FOR THE PREPARATION THEREOF | Kainos Medicine, Inc (KR) | 2010-02-25 | — | — | US | disclosed |
| US-20100048570-A1 | THIAZOLIDINE DERIVATIVES AND METHODS FOR THE PREPARATION THEREOF | Kainos Medicine, Inc (KR) | 2010-02-25 | — | — | US | disclosed |
| CN-101641360-A | Piperazine derivatives, preparation method and medical application thereof | SHANGHAI HENGRUI PHARM CO LTD | 2010-02-03 | — | — | CN | disclosed |
| CN-101641361-A | Tetrahydroimidazo [1, 5-a ] pyrazine derivative, preparation method and application thereof in medicine | SHANGHAI HENGRUI PHARM CO LTD | 2010-02-03 | — | — | CN | disclosed |
| EP-2142519-A1 | DPP-IV INHIBITOR INCLUDING BETA-AMINO GROUP, PREPARATION METHOD THEREOF AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME FOR PREVENTING AND TREATING A DIABETES OR AN OBESITY | Dong-A Pharm.Co., Ltd. (KR) | 2010-01-13 | — | — | EP | disclosed |
| EP-1554256-B1 | PIPERIDINO PYRIMIDINE DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OF DIABETES | MERCK & CO INC (US) | 2009-12-09 | — | — | EP | disclosed |
| EP-1554256-B1 | PIPERIDINO PYRIMIDINE DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OF DIABETES | MERCK & CO INC (US) | 2009-12-09 | — | — | EP | disclosed |
| EP-2125725-A1 | COMPOUNDS OF FORMULA (I) AS SERINE PROTEASE INHIBITORS | Novartis AG (CH) | 2009-12-02 | — | — | EP | disclosed |
| US-7625888-B2 | Fused triazole derivatives as dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes | MERCK & CO., INC. (US) | 2009-12-01 | — | — | US | disclosed |
| US-7625888-B2 | Fused triazole derivatives as dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes | MERCK & CO., INC. (US) | 2009-12-01 | — | — | US | disclosed |
| US-7625888-B2 | Fused triazole derivatives as dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes | MERCK & CO., INC. (US) | 2009-12-01 | — | — | US | disclosed |
| EP-2118081-A2 | THIAZOLIDINE DERIVATIVES AND METHODS FOR THE PREPARATION THEREOF | Kainos Medicine, Inc., (KR) | 2009-11-18 | — | — | EP | disclosed |
| EP-1624874-B1 | 3-AMINO-4-PHENYLBUTANOIC ACID DERIVATIVES AS DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES | MERCK & CO INC (US) | 2009-11-04 | — | — | EP | disclosed |
| EP-1624874-B1 | 3-AMINO-4-PHENYLBUTANOIC ACID DERIVATIVES AS DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES | MERCK & CO INC (US) | 2009-11-04 | — | — | EP | disclosed |
| WO-2009093269-A1 | NOVEL HETEROCYCLIC COMPOUNDS | PANACEA BIOTEC LIMITED (IN) | 2009-07-30 | — | — | WO | disclosed |
| US-20090192326-A1 | Preparation of sitagliptin intermediate | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2009-07-30 | — | — | US | disclosed |
| US-20090192326-A1 | Preparation of sitagliptin intermediate | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2009-07-30 | — | — | US | disclosed |
| US-20090192326-A1 | Preparation of sitagliptin intermediate | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2009-07-30 | — | — | US | disclosed |
| US-7560455-B2 | 3-Amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes | MERCK & CO., INC. (US) | 2009-07-14 | — | — | US | disclosed |
| US-7560455-B2 | 3-Amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes | MERCK & CO., INC. (US) | 2009-07-14 | — | — | US | disclosed |
| US-7560455-B2 | 3-Amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes | MERCK & CO., INC. (US) | 2009-07-14 | — | — | US | disclosed |
| EP-1784188-A4 | FUSED TRIAZOLE DERIVATIVES AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES | MERCK & CO INC (US) | 2009-06-24 | — | — | EP | disclosed |
| US-20090156465-A1 | DERIVATIVES OF BETA-AMINO ACID AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS | RANBAXY LABORATORIES LIMITED (IN) | 2009-06-18 | — | — | US | disclosed |
| WO-2009064476-A1 | PREPARATION OF SITAGLIPTIN INTERMEDIATE | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2009-05-22 | — | — | WO | disclosed |
| WO-2009064476-A1 | PREPARATION OF SITAGLIPTIN INTERMEDIATE | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2009-05-22 | — | — | WO | disclosed |
| EP-1592689-A4 | 3-AMINO-4-PHENYLBUTANOIC ACID DERIVATIVES AS DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES | MERCK & CO INC (US) | 2008-12-24 | — | — | EP | disclosed |
| EP-1651623-B1 | HEXAHYDRODIAZEPINONES AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES | MERCK & CO INC (US) | 2008-12-17 | — | — | EP | disclosed |
| EP-1651623-B1 | HEXAHYDRODIAZEPINONES AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES | MERCK & CO INC (US) | 2008-12-17 | — | — | EP | disclosed |
| WO-2008141021-A1 | DEUTERATED DERIVATIVES OF TETRAHYDROTRIAZOLOPYRAZINE COMPOUNDS AND THEIR USE AS DPP-IV INHIBITORS | CONCERT PHARMACEUTICALS, INC. (US) | 2008-11-20 | — | — | WO | disclosed |
| US-20080280913-A1 | TETRAHYDROTRIAZOLOPYRAZINE DERIVATIVES AND USES THEREOF | CONCERT PHARMACEUTICALS, INC. | 2008-11-13 | — | — | US | disclosed |
| US-20080280913-A1 | TETRAHYDROTRIAZOLOPYRAZINE DERIVATIVES AND USES THEREOF | CONCERT PHARMACEUTICALS, INC. | 2008-11-13 | — | — | US | disclosed |
| US-20080280913-A1 | TETRAHYDROTRIAZOLOPYRAZINE DERIVATIVES AND USES THEREOF | CONCERT PHARMACEUTICALS, INC. | 2008-11-13 | — | — | US | disclosed |
| WO-2008130151-A1 | DPP-IV INHIBITOR INCLUDING BETA-AMINO GROUP, PREPARATION METHOD THEREOF AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME FOR PREVENTING AND TREATING A DIABETES OR AN OBESITY | DONG-A PHARM. CO., LTD. (KR) | 2008-10-30 | — | — | WO | disclosed |
| EP-1973918-A2 | DERIVATIVES OF BETA-AMINO ACID AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS | RANBAXY LABORATORIES, LTD. (IN) | 2008-10-01 | — | — | EP | disclosed |
| WO-2008101953-A1 | COMPOUNDS OF FORMULA (I) AS SERINE PROTEASE INHIBITORS | NOVARTIS AG (CH) | 2008-08-28 | — | — | WO | disclosed |
| EP-1961742-A1 | compounds of formula (I) as serine protease inhibitors | Novartis AG (CH) | 2008-08-27 | — | — | EP | disclosed |
| WO-2008087560-A2 | THIAZOLIDINE DERIVATIVES AND METHODS FOR THE PREPARATION THEREOF | KAINOS MEDICINE, INC., (US) | 2008-07-24 | — | — | WO | disclosed |
| US-7390809-B2 | Beta-amino heterocyclic dipeptidyl peptidase inhibitors for diabetes | MERCK & CO., INC. (US) | 2008-06-24 | — | — | US | disclosed |
| US-7390809-B2 | Beta-amino heterocyclic dipeptidyl peptidase inhibitors for diabetes | MERCK & CO., INC. (US) | 2008-06-24 | — | — | US | disclosed |
| US-7390809-B2 | Beta-amino heterocyclic dipeptidyl peptidase inhibitors for diabetes | MERCK & CO., INC. (US) | 2008-06-24 | — | — | US | disclosed |
| US-7388019-B2 | 3-amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes | MERCK & CO., INC. (US) | 2008-06-17 | — | — | US | disclosed |
| US-7388019-B2 | 3-amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes | MERCK & CO., INC. (US) | 2008-06-17 | — | — | US | disclosed |
| US-7388019-B2 | 3-amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes | MERCK & CO., INC. (US) | 2008-06-17 | — | — | US | disclosed |
| EP-1905759-A1 | N-[1-(3-AMINO-4-PHENYL-BUTYRYL)-4-HYDROXY-PYRROLIDIN-2-YLMETHYL}-PROPIONAMIDE AND RELATED COMPOUNDS AS DPP-IV INHIBITORS FOR THE TREATMENT OFTYPE 2 DIABETES MELLITUS | Santhera Pharmaceuticals (Schweiz) AG (CH) | 2008-04-02 | — | — | EP | disclosed |
| EP-1905759-A1 | N-[1-(3-AMINO-4-PHENYL-BUTYRYL)-4-HYDROXY-PYRROLIDIN-2-YLMETHYL}-PROPIONAMIDE AND RELATED COMPOUNDS AS DPP-IV INHIBITORS FOR THE TREATMENT OFTYPE 2 DIABETES MELLITUS | Santhera Pharmaceuticals (Schweiz) AG (CH) | 2008-04-02 | — | — | EP | disclosed |
| EP-1556362-B1 | BETA-AMINO HETEROCYCLIC DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES | MERCK & CO INC (US) | 2008-03-26 | — | — | EP | disclosed |
| WO-2008028662-A1 | N-[1-(3-AMINO-4-PHENYL-BUTYRYL)-4-HYDROXY-PYRROLIDIN-2-YLMETHYL}-PROPIONAMIDE AND RELATED COMPOUNDS AS DPP-IV INHIBITORS FOR THE TREATMENT OF TYPE 2 DIABETES MELLITUS | SANTHERA PHARMACEUTICALS (SCHWEIZ) AG (CH) | 2008-03-13 | — | — | WO | disclosed |
| US-20080027035-A1 | Dpp-Iv Inhibitors | GRAFFINITY PHARMACEUTICALS AG (DE) | 2008-01-31 | — | — | US | disclosed |
| US-20080027035-A1 | Dpp-Iv Inhibitors | GRAFFINITY PHARMACEUTICALS AG (DE) | 2008-01-31 | — | — | US | disclosed |
| US-20080015146-A1 | Dpp-IV Inhibitors | SANTHERA PHARMACEUTICALS (DEUTSCHLAND) AG (DE) | 2008-01-17 | — | — | US | disclosed |
| US-20080015146-A1 | Dpp-IV Inhibitors | SANTHERA PHARMACEUTICALS (DEUTSCHLAND) AG (DE) | 2008-01-17 | — | — | US | disclosed |
| US-20080015146-A1 | Dpp-IV Inhibitors | SANTHERA PHARMACEUTICALS (DEUTSCHLAND) AG (DE) | 2008-01-17 | — | — | US | disclosed |
| US-20080009512-A1 | Tetrahydroquinolones and Aza-Analogues Thereof for Use as Dpp-IV Inhibitors in the Treatment of Diabetes | ASTRAZENECA AB (SE) | 2008-01-10 | — | — | US | disclosed |
| US-7307164-B2 | β-amino heterocyclic dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes | MERCK & CO., INC. (US) | 2007-12-11 | — | — | US | disclosed |
| US-7307164-B2 | β-amino heterocyclic dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes | MERCK & CO., INC. (US) | 2007-12-11 | — | — | US | disclosed |
| US-7307164-B2 | β-amino heterocyclic dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes | MERCK & CO., INC. (US) | 2007-12-11 | — | — | US | disclosed |
| EP-1490335-B1 | BETA-AMINO HETEROCYCLIC DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES | MERCK & CO INC (US) | 2007-09-19 | — | — | EP | disclosed |
| EP-1490335-B1 | BETA-AMINO HETEROCYCLIC DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES | MERCK & CO INC (US) | 2007-09-19 | — | — | EP | disclosed |
| EP-1613304-B1 | DPP-IV INHIBITORS | SANTHERA PHARMACEUTICALS CH (CH) | 2007-09-12 | — | — | EP | disclosed |
| US-20070208010-A1 | Fused Triazole Derivatives as Dipeptidyl Peptidase-IV Inhibitors for the Treatment or Prevention of Diabetes | MERCK SHARP & DOHME CORP. | 2007-09-06 | — | — | US | disclosed |
| US-20070208010-A1 | Fused Triazole Derivatives as Dipeptidyl Peptidase-IV Inhibitors for the Treatment or Prevention of Diabetes | MERCK SHARP & DOHME CORP. | 2007-09-06 | — | — | US | disclosed |
| US-20070208010-A1 | Fused Triazole Derivatives as Dipeptidyl Peptidase-IV Inhibitors for the Treatment or Prevention of Diabetes | MERCK SHARP & DOHME CORP. | 2007-09-06 | — | — | US | disclosed |
| US-7265128-B2 | 3-amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes | MERCK & CO., INC. (US) | 2007-09-04 | — | — | US | disclosed |
| US-7265128-B2 | 3-amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes | MERCK & CO., INC. (US) | 2007-09-04 | — | — | US | disclosed |
| US-7265128-B2 | 3-amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes | MERCK & CO., INC. (US) | 2007-09-04 | — | — | US | disclosed |
| EP-1583534-A4 | 3-AMINO-4-PHENYLBUTANOIC ACID DERIVATIVES AS DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES | MERCK & CO INC (US) | 2007-08-29 | — | — | EP | disclosed |
| US-20070197522-A1 | Dpp-iv inhibitors | SANTHERA PHARMACEUTICALS (SCHWEIZ) GMBH (CH) | 2007-08-23 | — | — | US | disclosed |
| US-20070197522-A1 | Dpp-iv inhibitors | SANTHERA PHARMACEUTICALS (SCHWEIZ) GMBH (CH) | 2007-08-23 | — | — | US | disclosed |
| US-20070197522-A1 | Dpp-iv inhibitors | SANTHERA PHARMACEUTICALS (SCHWEIZ) GMBH (CH) | 2007-08-23 | — | — | US | disclosed |
| US-7259160-B2 | Hexahydrodiazepinones as dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes | MERCK & CO., INC. (US) | 2007-08-21 | — | — | US | disclosed |
| US-7259160-B2 | Hexahydrodiazepinones as dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes | MERCK & CO., INC. (US) | 2007-08-21 | — | — | US | disclosed |
| US-7259160-B2 | Hexahydrodiazepinones as dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes | MERCK & CO., INC. (US) | 2007-08-21 | — | — | US | disclosed |
| EP-1554280-B1 | ANTIDIABETIC BETA-AMINO HETEROCYCLIC DIPEPTIDYL PEPTIDASE INHIBITORS | MERCK & CO INC (US) | 2007-08-15 | — | — | EP | disclosed |
| EP-1554280-B1 | ANTIDIABETIC BETA-AMINO HETEROCYCLIC DIPEPTIDYL PEPTIDASE INHIBITORS | MERCK & CO INC (US) | 2007-08-15 | — | — | EP | disclosed |
| WO-2007077508-A2 | DERIVATIVES OF BETA-AMINO ACID AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS | RANBAXY LABORATORIES LIMITED (IN) | 2007-07-12 | — | — | WO | disclosed |
| EP-1554256-A4 | PIPERIDINO PYRIMIDINE DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OF DIABETES | MERCK & CO INC (US) | 2007-06-13 | — | — | EP | disclosed |
| EP-1786806-A1 | DPP-IV INHIBITORS | Santhera Pharmaceuticals (Schweiz) AG (CH) | 2007-05-23 | — | — | EP | disclosed |
| EP-1784188-A2 | FUSED TRIAZOLE DERIVATIVES AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES | Merck & Co., Inc. (US) | 2007-05-16 | — | — | EP | disclosed |
| US-7208498-B2 | Piperidino pyrimidine dipeptidyl peptidase inhibitors for the treatment of diabetes | MERCK & CO., INC. (US) | 2007-04-24 | — | — | US | disclosed |
| US-7208498-B2 | Piperidino pyrimidine dipeptidyl peptidase inhibitors for the treatment of diabetes | MERCK & CO., INC. (US) | 2007-04-24 | — | — | US | disclosed |
| US-7208498-B2 | Piperidino pyrimidine dipeptidyl peptidase inhibitors for the treatment of diabetes | MERCK & CO., INC. (US) | 2007-04-24 | — | — | US | disclosed |
| EP-1758863-A1 | TETRAHYDROQUINOLONES AND AZA-ANALOGUES THEREOF FOR USE AS DPP-IV INHIBITORS IN THE TREATEMENT OF DIABETES | AstraZeneca AB (SE) | 2007-03-07 | — | — | EP | disclosed |
| US-20060270679-A1 | Beta-amino heterocyclic dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes | MERCK SHARP & DOHME CORP. | 2006-11-30 | — | — | US | disclosed |
| EP-1624874-A4 | 3-AMINO-4-PHENYLBUTANOIC ACID DERIVATIVES AS DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES | MERCK & CO INC (US) | 2006-11-22 | — | — | EP | disclosed |
| US-20060258646-A1 | 3-Amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes | MERCK SHARP & DOHME LLC | 2006-11-16 | — | — | US | disclosed |
| US-7125873-B2 | Beta-amino tetrahydroimidazo (1, 2-a) pyrazines and tetrahydrotrioazolo (4, 3-a) pyrazines as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes | MERCK & CO., INC. (US) | 2006-10-24 | — | — | US | disclosed |
| EP-1651623-A4 | HEXAHYDRODIAZEPINONES AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES | MERCK & CO INC (US) | 2006-10-04 | — | — | EP | disclosed |
| US-20060211682-A1 | Hexahydrodiazepinones as dipeptidyl peptidase-iv inhibitors for the treatment or prevention of diabetes | MERCK SHARP & DOHME LLC | 2006-09-21 | — | — | US | disclosed |
| US-7101871-B2 | Beta-amino heterocyclic dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes | MERCK & CO., INC. (US) | 2006-09-05 | — | — | US | disclosed |
| EP-1556362-A4 | BETA-AMINO HETEROCYCLIC DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES | MERCK & CO INC (US) | 2006-08-23 | — | — | EP | disclosed |
| EP-1554280-A4 | ANTIDIABETIC BETA-AMINO HETEROCYCLIC DIPEPTIDYL PEPTIDASE INHIBITORS | MERCK & CO INC (US) | 2006-07-05 | — | — | EP | disclosed |
| EP-1651623-A2 | HEXAHYDRODIAZEPINONES AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES | Merck & Co., Inc. (US) | 2006-05-03 | — | — | EP | disclosed |
| US-20060074087-A1 | 3-Amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes | MERCK SHARP & DOHME LLC | 2006-04-06 | — | — | US | disclosed |
| US-20060069116-A1 | 3-Amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes | MERCK SHARP & DOHME LLC | 2006-03-30 | — | — | US | disclosed |
| EP-1412357-B1 | BETA-AMINO TETRAHYDROIMIDAZO(1,2-A)PYRAZINES AND TETRAHYDROTRIAZOLO(4,3-A)PYRAZINES AS DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES | MERCK & CO INC (US) | 2006-03-22 | — | — | EP | disclosed |
| US-20060052382-A1 | 3-Amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes | MERCK & CO., INC. | 2006-03-09 | — | — | US | disclosed |
| WO-2006023750-A2 | FUSED TRIAZOLE DERIVATIVES AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES | MERCK & CO., INC. (US) | 2006-03-02 | — | — | WO | disclosed |
| US-20060040963-A1 | Piperidino pyrimidine dipeptidyl peptidase inhibitors for the treatment of diabetes | MERCK SHARP & DOHME LLC | 2006-02-23 | — | — | US | disclosed |
| EP-1624874-A2 | 3-AMINO-4-PHENYLBUTANOIC ACID DERIVATIVES AS DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES | Merck & Co., Inc. (US) | 2006-02-15 | — | — | EP | disclosed |
| EP-1625847-A1 | Pharmaceutical composition comprising a tetrahydrotriazolo[4,3-a]pyrazine | Merck & Co., Inc. (US) | 2006-02-15 | — | — | EP | disclosed |
| EP-1490335-A4 | BETA-AMINO HETEROCYCLIC DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES | MERCK & CO INC (US) | 2006-02-08 | — | — | EP | disclosed |
| US-20060014953-A1 | Beta-amino heterocyclic dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes | MERCK SHARP & DOHME LLC | 2006-01-19 | — | — | US | disclosed |
| WO-2005123685-A1 | TETRAHYDROQUINOLONES AND AZA-ANALOGUES THEREOF FOR USE AS DPP-IV INHIBITORS IN THE TREATEMENT OF DIABETES | ASTRAZENECA AB (SE) | 2005-12-29 | — | — | WO | disclosed |
| WO-2005121131-A1 | DPP-IV INHIBITORS | SANTHERA PHARMACEUTICALS (SCHWEIZ) AG (CH) | 2005-12-22 | — | — | WO | disclosed |
| WO-2005121131-A1 | DPP-IV INHIBITORS | SANTHERA PHARMACEUTICALS (SCHWEIZ) AG (CH) | 2005-12-22 | — | — | WO | disclosed |
| EP-1592689-A2 | 3-AMINO-4-PHENYLBUTANOIC ACID DERIVATIVES AS DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES | Merck & Co., Inc. (US) | 2005-11-09 | — | — | EP | disclosed |
| WO-2005095343-A1 | DPP-IV INHIBITORS | SANTHERA PHARMACEUTICALS (SCHWEIZ) GMBH (CH) | 2005-10-13 | — | — | WO | disclosed |
| EP-1583534-A1 | 3-AMINO-4-PHENYLBUTANOIC ACID DERIVATIVES AS DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES | Merck & Co., Inc. (US) | 2005-10-12 | — | — | EP | disclosed |
| EP-1556362-A2 | BETA-AMINO HETEROCYCLIC DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES | Merck & Co., Inc. (US) | 2005-07-27 | — | — | EP | disclosed |
| EP-1554280-A2 | ANTIDIABETIC BETA-AMINO HETEROCYCLIC DIPEPTIDYL PEPTIDASE INHIBITORS | Merck & Co., Inc. (US) | 2005-07-20 | — | — | EP | disclosed |
| EP-1554256-A1 | PIPERIDINO PYRIMIDINE DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OF DIABETES | Merck & Co., Inc. (US) | 2005-07-20 | — | — | EP | disclosed |
| WO-2005056003-A1 | DPP-IV INHIBITORS | SANTHERA PHARMACEUTICALS (SCHWEIZ) GMBH (CH) | 2005-06-23 | — | — | WO | disclosed |
| US-20050107390-A1 | Beta-amino heterocyclic dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes | MERCK SHARP & DOHME CORP. | 2005-05-19 | — | — | US | disclosed |
| WO-2005011581-A2 | HEXAHYDRODIAZEPINONES AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES | MERCK & CO., INC. (US) | 2005-02-10 | — | — | WO | disclosed |
| EP-1490335-A2 | BETA-AMINO HETEROCYCLIC DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES | Merck & Co., Inc. (US) | 2004-12-29 | — | — | EP | disclosed |
| US-20040254167-A1 | Beta-amino heterocyclic dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes | MERCK SHARP & DOHME CORP. | 2004-12-16 | — | — | US | disclosed |
| WO-2004103276-A2 | 3-AMINO-4-PHENYLBUTANOIC ACID DERIVATIVES AS DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES | MERCK & CO., INC. (US) | 2004-12-02 | — | — | WO | disclosed |
| WO-2004103276-A2 | 3-AMINO-4-PHENYLBUTANOIC ACID DERIVATIVES AS DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES | MERCK & CO., INC. (US) | 2004-12-02 | — | — | WO | disclosed |
| US-20040167133-A1 | Beta-amino tetrahydroimidazo (1, 2-a) pyrazines and tetrahydrotrioazolo (4,3-a) pyrazines as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes | MERCK SHARP & DOHME LLC | 2004-08-26 | — | — | US | disclosed |
| WO-2004069162-A2 | 3-AMINO-4-PHENYLBUTANOIC ACID DERIVATIVES AS DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES | MERCK & CO., INC. (US) | 2004-08-19 | — | — | WO | disclosed |
| WO-2004064778-A2 | 3-AMINO-4-PHENYLBUTANOIC ACID DERIVATIVES AS DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES | MERCK & CO. INC. (US) | 2004-08-05 | — | — | WO | disclosed |
| WO-2004058266-A1 | 3-AMINO-4-PHENYLBUTANOIC ACID DERIVATIVES AS DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES | MERCK & CO., INC. (US) | 2004-07-15 | — | — | WO | disclosed |
| WO-2004037169-A2 | BETA-AMINO HETEROCYCLIC DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES | MERCK & CO., INC. (US) | 2004-05-06 | — | — | WO | disclosed |
| WO-2004037169-A2 | BETA-AMINO HETEROCYCLIC DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES | MERCK & CO., INC. (US) | 2004-05-06 | — | — | WO | disclosed |
| EP-1412357-A1 | BETA-AMINO TETRAHYDROIMIDAZO(1,2-A)PYRAZINES AND TETRAHYDROTRIAZOLO(4,3-A)PYRAZINES AS DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES | Merck & Co., Inc. (US) | 2004-04-28 | — | — | EP | disclosed |
| WO-2004032836-A2 | ANTIDIABETIC BETA-AMINO HETEROCYLCIC DIPEPTIDYL PEPTIDASE INHIBITORS | MERCK & CO., INC. (US) | 2004-04-22 | — | — | WO | disclosed |
| WO-2004032836-A2 | ANTIDIABETIC BETA-AMINO HETEROCYLCIC DIPEPTIDYL PEPTIDASE INHIBITORS | MERCK & CO., INC. (US) | 2004-04-22 | — | — | WO | disclosed |
| US-6699871-B2 | SUCH AS 7-((3R)-3-AMINO-4-(3,4-DIFLUOROPHENYL)BUTANOYL)-2-(TRIFLUOROMETHYL)-5,6,7,8 -TETRAHYDROIMIDAZO(1,2-A)PYRAZINE DIHYDROCHLORIDE FOR TREATMENT OF INSULIN RESISTANCE DISORDERS | MERCK & CO., INC. | 2004-03-02 | — | — | US | disclosed |
| WO-2004007468-A1 | PIPERIDINO PYRIMIDINE DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OF DIABETES | MERCK & CO., INC. (US) | 2004-01-22 | — | — | WO | disclosed |
| WO-2004007468-A1 | PIPERIDINO PYRIMIDINE DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OF DIABETES | MERCK & CO., INC. (US) | 2004-01-22 | — | — | WO | disclosed |
| WO-2003082817-A2 | BETA-AMINO HETEROCYCLIC DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES | MERCK & CO., INC. (US) | 2003-10-09 | — | — | WO | disclosed |
| US-20030100563-A1 | Beta-amino heterocyclic dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes | SALZUFER HOLDING INC., AS ADMINISTRATIVE AGENT | 2003-05-29 | — | — | US | disclosed |
| WO-2003004498-A1 | BETA-AMINO TETRAHYDROIMIDAZO (1, 2-A) PYRAZINES AND TETRAHYDROTRIOAZOLO (4, 3-A) PYRAZINES AS DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES | MERCK & CO., INC. (US) | 2003-01-16 | — | — | WO | disclosed |
| WO-2003004498-A1 | BETA-AMINO TETRAHYDROIMIDAZO (1, 2-A) PYRAZINES AND TETRAHYDROTRIOAZOLO (4, 3-A) PYRAZINES AS DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES | MERCK & CO., INC. (US) | 2003-01-16 | — | — | WO | disclosed |
| WO-2003004498-A1 | BETA-AMINO TETRAHYDROIMIDAZO (1, 2-A) PYRAZINES AND TETRAHYDROTRIOAZOLO (4, 3-A) PYRAZINES AS DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES | MERCK & CO., INC. (US) | 2003-01-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (50 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080027035-A1 | Dpp-Iv Inhibitors | DPP4, DPP7, DPP3 | DPP4 1/4885ATM 4787/4885CTSS 505/4885 |
| US-20110190308-A1 | NOVEL CYCLIC AZABENZIMIDAZOLE DERIVATIVES USEFUL AS ANTI-DIABETIC AGENTS | DPP4, DPP3, DPP7 | DPP4 1/4885ATM 4820/4885CTSS 1498/4885 |
| US-20130130974-A1 | NOVEL SYNTHETIC APPROACH TO beta-AMINOBUTYRYL SUBSTITUTED COMPOUNDS | BCAT1, BCAT2, DDC | DPP4 153/4885ATM 2310/4885CTSS 2126/4885 |
| US-20060074087-A1 | 3-Amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes | DPP4, DPP3, DPP7 | DPP4 1/4885ATM 4721/4885CTSS 1879/4885 |
| US-20090192326-A1 | Preparation of sitagliptin intermediate | DPP4, DPP7, DPP3 | DPP4 1/4885ATM 2081/4885CTSS 1611/4885 |
| US-20130217695-A1 | BETA-AMINO HETEROCYCLIC DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES | DPP4, DPP3, DPP7 | DPP4 1/4885ATM 4777/4885CTSS 702/4885 |
| US-20150025241-A1 | METHOD FOR PREPARING DIPEPTIDYL PEPTIDASE-IV INHIBITOR AND INTERMEDIATE | DPP4, DPP3, DPP7 | DPP4 1/4885ATM 4783/4885CTSS 460/4885 |
| US-20050107390-A1 | Beta-amino heterocyclic dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes | DPP4, DPP3, DPP7 | DPP4 1/4885ATM 4777/4885CTSS 702/4885 |
| US-20220153772-A1 | GLUCOSIDE DERIVATIVE THAT ACTS AS SGLT1 INHIBITOR AND APPLICATION THEREOF | SLC5A1, SLC5A2, UGGT1 | DPP4 74/4885ATM 3598/4885CTSS 3913/4885 |
| US-20200206221-A1 | BETA-AMINO HETEROCYCLIC DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES | DPP4, DPP3, DPP7 | DPP4 1/4885ATM 4777/4885CTSS 702/4885 |
| US-20230174461-A1 | METHOD FOR PREPARING CHIRAL 4-ARYL-ß-AMINO ACID DERIVATIVE | ENPEP, BCAT2, BCAT1 | DPP4 330/4885ATM 3602/4885CTSS 1765/4885 |
| US-20120016126-A1 | METHOD FOR MANUFACTURING DIPEPTIDYL PEPTIDASE-IV INHIBITOR AND INTERMEDIATE | DPP4, DPP3, DPP7 | DPP4 1/4885ATM 4671/4885CTSS 584/4885 |
| US-20150359793-A1 | BETA-AMINO HETEROCYCLIC DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES | DPP4, DPP3, DPP7 | DPP4 1/4885ATM 4777/4885CTSS 702/4885 |
| US-20060052382-A1 | 3-Amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes | DPP4, DPP3, DPP7 | DPP4 1/4885ATM 4721/4885CTSS 1879/4885 |
| US-20040167133-A1 | Beta-amino tetrahydroimidazo (1, 2-a) pyrazines and tetrahydrotrioazolo (4,3-a) pyrazines as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes | DPP4, DPP3, DPP7 | DPP4 1/4885ATM 4824/4885CTSS 1545/4885 |
| US-20070208010-A1 | Fused Triazole Derivatives as Dipeptidyl Peptidase-IV Inhibitors for the Treatment or Prevention of Diabetes | DPP4, DPP3, DPP7 | DPP4 1/4885ATM 4295/4885CTSS 674/4885 |
| US-20140005394-A1 | PREPARATION METHOD OF INTERMEDIATE OF SITAGLIPTIN | DPP4, DPP7, DPP9 | DPP4 1/4885ATM 2578/4885CTSS 2539/4885 |
| US-20100076024-A1 | Novel Compounds as Serine Protease Inhibitors | PRSS1, SERPINB1, SPINT2 | DPP4 97/4885ATM 1978/4885CTSS 47/4885 |
| US-20060014953-A1 | Beta-amino heterocyclic dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes | DPP4, DPP3, DPP7 | DPP4 1/4885ATM 4777/4885CTSS 702/4885 |
| US-20180086765-A1 | NOVEL INTERMEDIATES FOR PREPARING DPP-IV INHIBITORS, PREPARING METHOD THEREOF AND PREPARING METHOD OF DPP-IV INHIBITORS USING THE SAME | DPP4, DPP7, DPP9 | DPP4 1/4885ATM 4429/4885CTSS 973/4885 |
| US-20120016125-A1 | METHOD FOR PREPARING DIPEPTIDYL PEPTIDASE-IV INHIBITOR AND INTERMEDIATE | DPP4, DPP3, DPP7 | DPP4 1/4885ATM 4783/4885CTSS 460/4885 |
| US-20060270679-A1 | Beta-amino heterocyclic dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes | DPP4, DPP3, DPP7 | DPP4 1/4885ATM 4777/4885CTSS 702/4885 |
| US-20120108598-A1 | SITAGLIPTIN SYNTHESIS | DPP4, DPP7, DPP3 | DPP4 1/4885ATM 3633/4885CTSS 1121/4885 |
| US-20120214997-A1 | METHOD OF PREPARING SITAGLIPTIN AND INTERMEDIATES USED THEREIN | DPP4, DPP7, DPP8 | DPP4 1/4885ATM 2389/4885CTSS 2077/4885 |
| US-20120178957-A1 | SITAGLIPTIN INTERMEDIATES, PREPARATION METHODS AND USES THEREOF | DPP4, DPP8, DPP9 | DPP4 1/4885ATM 1645/4885CTSS 2017/4885 |
| US-20130178500-A1 | HEXAHYDROPYRROLO[3,4-b]PYRROLE DERIVATIVES, PREPARATION METHODS AND PHARMACEUTICAL USES THEREOF | DPP4, DPP3, DPP7 | DPP4 1/4885ATM 4814/4885CTSS 776/4885 |
| US-20070197522-A1 | Dpp-iv inhibitors | DPP7, DPP4, DPP3 | DPP4 2/4885ATM 4757/4885CTSS 261/4885 |
| US-20150087834-A1 | PROCESS FOR THE PREPARATION OF SITAGLIPTIN PHOSPHATE | DPP4, DPP9, SI | DPP4 1/4885ATM 2304/4885CTSS 1448/4885 |
| US-20080015146-A1 | Dpp-IV Inhibitors | DPP4, DPP9, DPP3 | DPP4 1/4885ATM 4682/4885CTSS 550/4885 |
| US-20100317856-A1 | PROCESS FOR THE PREPARATION OF R-SITAGLIPTIN AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF | DPP4, DPP9, DPP3 | DPP4 1/4885ATM 2893/4885CTSS 404/4885 |
| US-20120220766-A1 | TETRAHYDRO-IMIDAZO[1,5-alpha] PYRAZINE DERIVATIVES, PREPERATION PROCESS AND MEDICINAL USE THEREOF | DPP4, DPP3, DPP7 | DPP4 1/4885ATM 4729/4885CTSS 883/4885 |
| US-20130137852-A1 | NOVEL COMPOUNDS AS DPP-IV INHIBITORS AND PROCESS FOR PREPARATION THEREOF | DPP4, DPP7, DPP3 | DPP4 1/4885ATM 4704/4885CTSS 443/4885 |
| US-20100120790-A1 | DPP-IV INHIBITOR INCLUDING BETA-AMINO GROUP, PREPARATION METHOD THEREOF AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME FOR PREVENTING AND TREATING DIABETES OR OBESITY | DPP4, DPP7, DPP3 | DPP4 1/4885ATM 4500/4885CTSS 2017/4885 |
| US-20040254167-A1 | Beta-amino heterocyclic dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes | DPP4, DPP3, DPP7 | DPP4 1/4885ATM 4803/4885CTSS 877/4885 |
| US-20060211682-A1 | Hexahydrodiazepinones as dipeptidyl peptidase-iv inhibitors for the treatment or prevention of diabetes | DPP4, DPP3, DPP7 | DPP4 1/4885ATM 4735/4885CTSS 933/4885 |
| US-20100130504-A1 | BETA-AMINO HETEROCYCLIC DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES | DPP4, DPP3, DPP7 | DPP4 1/4885ATM 4777/4885CTSS 702/4885 |
| US-20150197523-A1 | PROCESS FOR THE PREPARATION OF SITAGLIPTIN AND INTERMEDIATE COMPOUNDS | DPP4, DPP7, DPP9 | DPP4 1/4885ATM 3694/4885CTSS 1668/4885 |
| US-20130012735-A1 | SITAGLIPTIN INTERMEDIATE COMPOUNDS, PREPARATION METHODS AND USES THEREOF | DPP4, DPP9, DPP3 | DPP4 1/4885ATM 3185/4885CTSS 1686/4885 |
| US-20030100563-A1 | Beta-amino heterocyclic dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes | DPP4, DPP3, DPP7 | DPP4 1/4885ATM 4805/4885CTSS 806/4885 |
| US-20080009512-A1 | Tetrahydroquinolones and Aza-Analogues Thereof for Use as Dpp-IV Inhibitors in the Treatment of Diabetes | DPP4, DPP8, DPP3 | DPP4 1/4885ATM 4439/4885CTSS 2636/4885 |
| US-20060069116-A1 | 3-Amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes | DPP4, DPP3, DPP7 | DPP4 1/4885ATM 4721/4885CTSS 1879/4885 |
| US-20240174675-A1 | SMALL MOLECULE REGULATORS OF ALVEOLAR TYPE 2 CELL PROLIFERATION FOR THE TREATMENT OF PULMONARY DISEASES | DPP4, DPP7, DPP3 | DPP4 1/4885ATM 624/4885CTSS 467/4885 |
| US-20130281695-A1 | INTERMEDIATES OF SITAGLIPTIN AND PREPARATION PROCESS THEREOF | DPP4, DPP9, DPP3 | DPP4 1/4885ATM 776/4885CTSS 978/4885 |
| US-20060258646-A1 | 3-Amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes | DPP4, DPP3, DPP7 | DPP4 1/4885ATM 4738/4885CTSS 1633/4885 |
| US-20160194680-A1 | Enzymatic Route For The Preparation Of Chiral Gamma-Aryl-Beta-Aminobutyric Acid Derivatives | GABRB1, GABRB2, GABRB3 | DPP4 431/4885ATM 4783/4885CTSS 848/4885 |
| US-20170305822-A1 | METHOD FOR PREPARING SITAGLIPTIN INTERMEDIATE VIA ASYMMETRICAL REDUCTION METHOD | DPP4, DPP7, SI | DPP4 1/4885ATM 1614/4885CTSS 1108/4885 |
| US-20150148533-A1 | New Synthetic Route For The Preparation Of Beta-aminobutyryl Substituted 5,6,7,8-tetrahydro[1,4]diazolo[4,3-alpha]Pyrazin-7-yl Compounds | GABRB3, GABRB1, GABRB2 | DPP4 40/4885ATM 3010/4885CTSS 4225/4885 |
| US-20100311732-A1 | NOVEL HETEROCYCLIC COMPOUNDS | DPP4, DPP3, DPP8 | DPP4 1/4885ATM 4807/4885CTSS 235/4885 |
| US-20060040963-A1 | Piperidino pyrimidine dipeptidyl peptidase inhibitors for the treatment of diabetes | DPP4, DPP3, DPP7 | DPP4 1/4885ATM 4802/4885CTSS 1145/4885 |
| US-20120065209-A1 | TETRAHYDRO-IMIDAZO[1,5-a]PYRAZINE DERIVATIVES SALTS, PREPARATION METHODS AND MEDICINAL USE THEREOF | DPP4, DPP7, DPP3 | DPP4 1/4885ATM 4751/4885CTSS 449/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.