Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 3/20 | 0.45 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.45 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.45 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.45 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.45 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.38 |
| ▸ | CHRNA6 | Q15825 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8704953 | 0.77 | CHRNB2 (0.47) | CHRNB2CHRNB4CHRNA3CHRNB1CHRNB3 | |
| SCHEMBL27782824 | 0.77 | SLC18A3 (0.54) | — | |
| SCHEMBL8134466 | 0.77 | CHRNB2 (0.41) | CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL8704582 | 0.77 | CYP2A6 (0.43) | CHRNB2CHRNB4CHRNA3CHRNB1CHRNB3 | |
| SCHEMBL8135453 | 0.77 | CHRNB2 (0.41) | CHRNB2CHRNB4CHRNA3CHRNA4 | |
| Hydrochloric Acid SCHEMBL7000218 | 0.72 | CHRNA7 (0.36) | CHRNB2CHRNA4CHRNA7 | |
| SCHEMBL10740876 | 0.69 | SMN1; SMN2 (0.57) | — | |
| SCHEMBL2080952 | 0.68 | CHRNB2 (0.48) | CHRNB2CHRNA4 | |
| SCHEMBL2081287 | 0.67 | CHRNB4 (0.48) | CHRNB2CHRNB4CHRNA3CHRNB1CHRNA4 | |
| SCHEMBL2081206 | 0.67 | CHRNB2 (0.47) | CHRNB2CHRNB4CHRNA3CHRNA4CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0970083-B1 | 7a-HETEROCYCLE-SUBSTITUTED HEXAHYDRO-1H-PYRROLIZINE COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION | ABBOTT LAB (US) | 2003-04-16 | — | — | EP | claimed |
| US-5733912-A | NERVOUS SYSTEM DISORDERS IN NERVE CELLS | ABBOTT LABORATORIES (US) | 1998-03-31 | — | — | US | disclosed |