Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC18A3 | Q16572 | 7/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | APEX1 | P27695 | 1/20 | 0.49 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10740876 | 0.90 | SMN1; SMN2 (0.57) | SLC18A3SMN1; SMN2 | |
| SCHEMBL27625961 | 0.80 | SLC18A3 (0.51) | SLC18A3SMN1; SMN2CYP2D6TSHRCYP1A2 | |
| SCHEMBL27719321 | 0.79 | SLC6A9 (0.50) | SLC18A3 | |
| SCHEMBL13119224 | 0.78 | HPGD (0.53) | SLC18A3SMN1; SMN2 | |
| SCHEMBL13116655 | 0.78 | HPGD (0.53) | SLC18A3SMN1; SMN2 | |
| SCHEMBL5556937 | 0.77 | SLC6A9 (0.54) | — | |
| SCHEMBL5556935 | 0.77 | SLC6A9 (0.54) | — | |
| SCHEMBL8286207 | 0.77 | SLC6A9 (0.54) | — | |
| SCHEMBL5562017 | 0.77 | SLC6A9 (0.54) | — | |
| SCHEMBL6991046 | 0.77 | CHRNB2 (0.45) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101583612-A | Azetidinone derivatives for the treatment of lipid metabolism disorders | SCHERING CORP (US) | 2009-11-18 | — | — | CN | disclosed |
| CN-101528227-A | Azetidinone derivatives and methods of use thereof | SCHERING CORP (US) | 2009-09-09 | — | — | CN | disclosed |
| CN-101528746-A | Spirocyclic azetidinone derivatives for the treatment of disorders of lipid metabolism, pain, diabetes and other disorders | SCHERING CORP (US) | 2009-09-09 | — | — | CN | disclosed |