Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 17/20 | 0.65 |
| ▸ | PGR | P06401 | 12/20 | 0.65 |
| ▸ | AR | P10275 | 3/20 | 0.51 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6291123 | 1.00 | NR3C1 (0.65) | NR3C1PGRARNR3C2 | |
| SCHEMBL6291127 | 1.00 | NR3C1 (0.65) | NR3C1PGRARNR3C2 | |
| SCHEMBL6294368 | 0.90 | NR3C1 (0.68) | NR3C1PGRAR | |
| SCHEMBL6294458 | 0.87 | PGR (0.69) | NR3C1PGRARNR3C2 | |
| SCHEMBL4180178 | 0.87 | PGR (0.69) | NR3C1PGRARNR3C2 | |
| SCHEMBL4167735 | 0.87 | PGR (0.69) | NR3C1PGRARNR3C2 | |
| SCHEMBL6291106 | 0.82 | PGR (0.69) | NR3C1PGRARNR3C2 | |
| SCHEMBL6294840 | 0.82 | NR3C1 (0.79) | NR3C1PGRAR | |
| SCHEMBL6291670 | 0.82 | NR3C1 (0.67) | NR3C1PGRARNR3C2 | |
| SCHEMBL6995370 | 0.82 | PGR (0.80) | NR3C1PGRARNR3C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6506766-B1 | A pharmaceutical composition for use in treating inflammation, immune, autoimmune, and inflammatory diseases in a mammal by selectively modulating the activation, repression, agonism, and antagonism effects of the mammal's glucocorticoid | ABBOTT LABORATORIES | 2003-01-14 | — | — | US | claimed |
| EP-1053239-B1 | GLUCOCORTICOID-SELECTIVE ANTI-INFLAMMATORY AGENTS | ABBOTT LAB (US) | 2003-01-08 | — | — | EP | claimed |
| US-6506766-B1 | A pharmaceutical composition for use in treating inflammation, immune, autoimmune, and inflammatory diseases in a mammal by selectively modulating the activation, repression, agonism, and antagonism effects of the mammal's glucocorticoid | ABBOTT LABORATORIES | 2003-01-14 | — | — | US | disclosed |
| EP-1053239-B1 | GLUCOCORTICOID-SELECTIVE ANTI-INFLAMMATORY AGENTS | ABBOTT LAB (US) | 2003-01-08 | — | — | EP | disclosed |