Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCA | P17252 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | ELANE | P08246 | 4/20 | 0.31 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.31 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.31 |
| ▸ | BTN3A1 | O00481 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6991459 | 0.80 | PRKCA (0.42) | PRKCAPOLBGAANPSR1ELANE | |
| SCHEMBL12360855 | 0.78 | PRKCA (0.41) | PRKCAPOLBGAANPSR1ELANE | |
| SCHEMBL7348874 | 0.74 | PRKCA (0.38) | PRKCAPOLBGAANPSR1ELANE | |
| SCHEMBL20299385 | 0.74 | PRKCA (0.38) | PRKCAPOLBGAANPSR1ELANE | |
| SCHEMBL7348875 | 0.73 | PRKCA (0.37) | PRKCAPOLBGAANPSR1BTN3A1 | |
| SCHEMBL4258156 | 0.71 | POLB (0.48) | PRKCAPOLBGAANPSR1ELANE | |
| SCHEMBL681950 | 0.71 | PRKCA (0.46) | PRKCAPOLBGAANPSR1ELANE | |
| SCHEMBL63686 | 0.69 | — | — | |
| SCHEMBL126096 | 0.69 | — | — | |
| SCHEMBL63687 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0641343-B1 | 4-MERCAPTOACETYLAMINO-[2] BENZAZEPINONE(3) DERIVATIVES, AND USE AS ENKEPHALINASE INHIBITORS | MERRELL PHARMA INC (US) | 2003-06-25 | — | — | EP | disclosed |
| EP-0656001-B1 | NOVEL 2-SUBSTITUTED INDANE-2-MERCAPTOACETYLAMIDE TRICYCLIC DERIVATIVES USEFUL AS INHIBITORS OF ENKEPHALINASE | MERRELL PHARMA INC (US) | 1999-09-15 | — | — | EP | disclosed |
| US-5491142-A | 2-substituted indane-2-mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase | MERRELL DOW PHARMACEUTICALS INC. (US) | 1996-02-13 | — | — | US | disclosed |
| US-5491141-A | ENZYME INHIBITORS, HYPERTENSIVE AGENTS; TREATING DIURETIC, CONGESTIVE HEART FAILURE, ALDOSTERONISM, RENAL DISEASES, GLAUCOMA | MERRELL DOW PHARMACEUTICALS INC. (US) | 1996-02-13 | — | — | US | disclosed |
| EP-0656001-A1 | NOVEL 2-SUBSTITUTED INDANE-2-MERCAPTOACETYLAMIDE TRICYCLIC DERIVATIVES USEFUL AS INHIBITORS OF ENKEPHALINASE | MERRELL PHARMACEUTICALS INC. (US) | 1995-06-07 | — | — | EP | disclosed |
| US-5420271-A | Analgesics, cardiovascular disorders, diuretics or hypoaldosteronemic agents | MERRELL DOW PHARMACEUTICALS, INC. (US) | 1995-05-30 | — | — | US | disclosed |
| EP-0641343-A1 | 4-MERCAPTOACETYLAMINO- 2] BENZAZEPINONE(3) DERIVATIVES, AND USE AS ENKEPHALINASE INHIBITORS | MERRELL PHARMACEUTICALS INC. (US) | 1995-03-08 | — | — | EP | disclosed |
| WO-1994004531-A1 | NOVEL 2-SUBSTITUTED INDANE-2-MERCAPTOACETYLAMIDE TRICYCLIC DERIVATIVES USEFUL AS INHIBITORS OF ENKEPHALINASE | MERRELL DOW PHARMACEUTICALS INC. (US) | 1994-03-03 | — | — | WO | disclosed |
| WO-1993023397-A1 | 4-MERCAPTOACETYLAMINO-[2] BENZAZEPINONE(3) DERIVATIVES, AND USE AS ENKEPHALINASE INHIBITORS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-11-25 | — | — | WO | disclosed |
| US-5238932-A | Mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-08-24 | — | — | US | disclosed |