Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.50 |
| ▸ | PGR | P06401 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.46 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.45 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.45 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.44 |
| ▸ | TDO2 | P48775 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | F2 | P00734 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6997691 | 0.73 | NPC1 (0.40) | HPGDPGRNPC1RAB9ANOTUM | |
| SCHEMBL8383654 | 0.72 | NISCH (0.46) | HPGDPGRNPC1RAB9ANOTUM | |
| SCHEMBL3041896 | 0.72 | HPGD (0.51) | HPGDNPC1RAB9ANOTUMNCOA1 | |
| SCHEMBL24534483 | 0.72 | HPGD (0.61) | HPGDNPC1RAB9ANOTUMNCOA1 | |
| SCHEMBL28613547 | 0.71 | HDAC4 (0.51) | HPGDPGRNOTUMNCOA1NCOA3 | |
| SCHEMBL24534874 | 0.70 | NPC1 (0.74) | HPGDNPC1RAB9ANOTUMDAPK3 | |
| SCHEMBL4158013 | 0.70 | PGR (0.81) | PGRNOTUMNCOA1NCOA3HDAC4 | |
| SCHEMBL29489425 | 0.69 | CYP3A4 (0.73) | NOTUMHDAC4HDAC8DYRK1ACLK4 | |
| SCHEMBL196765 | 0.69 | CYP3A4 (0.73) | NOTUMHDAC4HDAC8DYRK1ACLK4 | |
| SCHEMBL1996001 | 0.69 | KDM4E (0.51) | NOTUMNCOA1NCOA3DYRK1ACLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863906-B1 | HETEROCYCLIC DIOXETHANE SUBSTRATES, PROCESS FOR THEIR PREPARATION AND THEIR USE | ROCHE DIAGNOSTICS GMBH (DE) | 2003-02-12 | — | — | EP | disclosed |
| US-6107036-A | Heterocyclic dioxethane substrates, process for their preparation and their use | ROCHE DIAGNOSTICS GMBH (DE) | 2000-08-22 | — | — | US | disclosed |
| EP-0863906-A2 | HETEROCYCLIC DIOXETHANE SUBSTRATES, PROCESS FOR THEIR PREPARATION AND THEIR USE | Roche Diagnostics GmbH (DE) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997014696-A2 | HETEROCYCLIC DIOXETHANE SUBSTRATES, PROCESS FOR THEIR PREPARATION AND THEIR USE | BOEHRINGER MANNHEIM GMBH (DE) | 1997-04-24 | — | — | WO | disclosed |