Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B2 | P37059 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | STS | P08842 | 2/20 | 0.39 |
| ▸ | CTSL | P07711 | 1/20 | 0.39 |
| ▸ | KLK7 | P49862 | 6/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.38 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.38 |
| ▸ | KLK5 | Q9Y337 | 5/20 | 0.37 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.37 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.37 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | CETP | P11597 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3206265 | 0.86 | KLK7 (0.50) | STSKLK7NR1H2NR1H3KLK5 | |
| SCHEMBL10132370 | 0.78 | ALDH1A1 (0.50) | SMN1; SMN2STSNR1H2NR1H3P2RX7 | |
| SCHEMBL247530 | 0.76 | KLK7 (0.54) | STSKLK7NR1H2NR1H3KLK5 | |
| SCHEMBL14932460 | 0.75 | GRM2 (0.41) | SMN1; SMN2STSKLK7NR1H2NR1H3 | |
| SCHEMBL22266043 | 0.75 | SMN1; SMN2 (0.50) | HSD17B2SMN1; SMN2STSNR1H2TP53 | |
| SCHEMBL31080065 | 0.74 | GLA (0.38) | SMN1; SMN2KLK7NR1H2KLK5PRSS1 | |
| SCHEMBL1519933 | 0.73 | SMN1; SMN2 (0.45) | HSD17B2SMN1; SMN2STSCTSLNR1H2 | |
| SCHEMBL1519935 | 0.73 | SMN1; SMN2 (0.45) | HSD17B2SMN1; SMN2STSCTSLNR1H2 | |
| SCHEMBL3161476 | 0.73 | SMN1; SMN2 (0.58) | SMN1; SMN2STSTP53POLB | |
| SCHEMBL16787408 | 0.72 | MAPT (0.42) | KLK7NR1H2NR1H3KLK5GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8889683-B2 | Substituted quinoxalines as inhibitors of fatty acid binding protein | MERCK SHARP & DOHME CORP. (US) | 2014-11-18 | — | — | US | disclosed |
| US-8889683-B2 | Substituted quinoxalines as inhibitors of fatty acid binding protein | MERCK SHARP & DOHME CORP. (US) | 2014-11-18 | — | — | US | disclosed |
| US-20120122837-A1 | INHIBITORS OF FATTY ACID BINDING PROTEIN | MERCK SHARP & DOHME LLC | 2012-05-17 | — | — | US | disclosed |
| US-20120122837-A1 | INHIBITORS OF FATTY ACID BINDING PROTEIN | MERCK SHARP & DOHME LLC | 2012-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120122837-A1 | INHIBITORS OF FATTY ACID BINDING PROTEIN | FABP4, FABP1, FABP3 | HSD17B2 1758/4885SMN1; SMN2 4592/4885STS 4531/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.