Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 3/20 | 0.49 |
| ▸ | FADS1 | O60427 | 3/20 | 0.45 |
| ▸ | NSD2 | O96028 | 1/20 | 0.41 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | METAP1 | P53582 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6987111 | 0.78 | NOTUM (0.50) | NOTUMFADS1NSD2ALOX5DRD2 | |
| SCHEMBL9105102 | 0.78 | NOTUM (0.53) | NOTUMFADS1NSD2ALOX5DRD2 | |
| SCHEMBL6984473 | 0.78 | NOTUM (0.53) | NOTUMFADS1NSD2ALOX5DRD2 | |
| SCHEMBL6992302 | 0.75 | NOTUM (0.50) | NOTUMFADS1NSD2GRM2ALOX5 | |
| SCHEMBL6988377 | 0.73 | FADS1 (0.55) | NOTUMFADS1NSD2GRM2 | |
| SCHEMBL6985886 | 0.73 | NOTUM (0.60) | NOTUMNSD2ALOX5DRD2DRD3 | |
| SCHEMBL6985389 | 0.72 | NOTUM (0.47) | NOTUMFADS1NSD2GRM2DRD2 | |
| SCHEMBL14632427 | 0.71 | NOTUM (0.57) | NOTUMALOX5DRD2DRD3 | |
| SCHEMBL6988378 | 0.71 | NOTUM (0.57) | NOTUMALOX5DRD2DRD3 | |
| SCHEMBL6839819 | 0.70 | NOTUM (0.56) | NOTUMALOX5DRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1301506-A1 | CYCLIC AMINO ACID DERIVATIVES | MERCK PATENT GmbH (DE) | 2003-04-16 | — | — | EP | disclosed |
| WO-2002006269-A1 | CYCLIC AMINO ACID DERIVATIVES | MERCK PATENT GMBH (DE) | 2002-01-24 | — | — | WO | disclosed |