Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.63 |
| ▸ | LMNA | P02545 | 2/20 | 0.63 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | EGFR | P00533 | 4/20 | 0.57 |
| ▸ | GFER | P55789 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27476499 | 1.00 | SMN1; SMN2 (0.63) | SMN1; SMN2LMNANPC1EGFRGFER | |
| SCHEMBL24003686 | 0.83 | P2RX7 (0.64) | SMN1; SMN2LMNANPC1EGFRGFER | |
| SCHEMBL1467988 | 0.83 | SMN1; SMN2 (0.61) | SMN1; SMN2LMNANPC1EGFRGFER | |
| SCHEMBL8707413 | 0.83 | SMN1; SMN2 (0.61) | SMN1; SMN2LMNANPC1EGFRGFER | |
| SCHEMBL9372706 | 0.80 | SMN1; SMN2 (0.58) | SMN1; SMN2LMNANPC1EGFRGFER | |
| SCHEMBL8299753 | 0.80 | TDP1 (0.68) | SMN1; SMN2LMNANPC1ALDH1A1GAA | |
| SCHEMBL7291545 | 0.80 | SMN1; SMN2 (0.58) | SMN1; SMN2LMNANPC1EGFRGFER | |
| SCHEMBL950218 | 0.79 | LMNA (0.73) | SMN1; SMN2LMNANPC1EGFRGFER | |
| SCHEMBL13701715 | 0.79 | SMN1; SMN2 (0.57) | SMN1; SMN2LMNANPC1EGFRGFER | |
| SCHEMBL24571401 | 0.79 | SMN1; SMN2 (0.56) | SMN1; SMN2LMNANPC1EGFRGFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2160391-B1 | NICOTINAMIDE DERIVATIVES AS SYNTHESIS UNITS FOR PRODUCING AGROCHEMICAL SUBSTANCES, AND METHOD FOR THE PRODUCTION THEREOF | BAYER CROPSCIENCE AG (DE) | 2010-08-04 | — | — | EP | disclosed |
| US-20100190992-A1 | Nicotinamide derivatives as synthesis units for producing agrochemical substances, and method for the production thereof | BAYER CROPSCIENCE AG (DE) | 2010-07-29 | — | — | US | disclosed |
| US-20100190992-A1 | Nicotinamide derivatives as synthesis units for producing agrochemical substances, and method for the production thereof | BAYER CROPSCIENCE AG (DE) | 2010-07-29 | — | — | US | disclosed |
| EP-2014658-A1 | Nicotinamide derivatives and method for their manufacture | Bayer CropScience AG (DE) | 2009-01-14 | — | — | EP | disclosed |
| WO-2008155003-A1 | NICOTINAMIDE DERIVATIVES AS SYNTHESIS UNITS FOR PRODUCING AGROCHEMICAL SUBSTANCES, AND METHOD FOR THE PRODUCTION THEREOF | BAYER CROPSCIENCE AG (DE) | 2008-12-24 | — | — | WO | disclosed |
| EP-1358169-A2 | DIAMINOTHIAZOLES AND THEIR USE AS INHIBITORS OF CYCLIN-DEPENDENT KINASE | F. HOFFMANN-LA ROCHE AG (CH) | 2003-11-05 | — | — | EP | disclosed |
| EP-0779281-B1 | ISOXAZOLES | SANKYO CO (JP) | 2003-10-29 | — | — | EP | disclosed |
| WO-2002057261-A2 | DIAMINOTHIAZOLES AND THEIR USE AS INHIBITORS OF CYCLIN-DEPENDENT KINASE | F. HOFFMANN-LA ROCHE AG (CH) | 2002-07-25 | — | — | WO | disclosed |
| US-6096771-A | ISOXAZOLE DERIVATIVES EXHIBITING EXCELLENT TYPE B AND TYPE A MONOAMINE OXIDASE INHIBITORY ACTIVITIES, THEREFORE USEFUL FOR PREVENTING PARKINSON'S DISEASE, DEPRESSION AND ALZHEIMER'S DISEASE | SANKYO COMPANY, LIMITED (JP) | 2000-08-01 | — | — | US | disclosed |
| US-5965591-A | MONOAMINE OXIDASE INHIBITOR; FOR PROPHYLAXIS AND TREATING PARKINSON'S DISEASE, DEPRESSION AND ALZHEIMER'S DISEASE | SANKYO COMPANY, LIMITED (JP) | 1999-10-12 | — | — | US | disclosed |
| EP-0779281-A1 | ISOXAZOLES | SANKYO COMPANY LIMITED (JP) | 1997-06-18 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100190992-A1 | Nicotinamide derivatives as synthesis units for producing agrochemical substances, and method for the production thereof | NAMPT, NQO1, NNT | SMN1; SMN2 2622/4885LMNA 2360/4885NPC1 881/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.