Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 2/20 | 0.71 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.71 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.56 |
| ▸ | TBXAS1 | P24557 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | PRKCI | P41743 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15179017 | 0.88 | CYP19A1 (0.64) | CYP11B1CYP11B2CYP19A1TBXAS1 | |
| SCHEMBL9323999 | 0.87 | CYP11B1 (0.58) | CYP11B1CYP11B2CYP19A1TBXAS1MEN1 | |
| SCHEMBL30674929 | 0.87 | CYP11B1 (0.58) | CYP11B1CYP11B2CYP19A1TBXAS1MEN1 | |
| SCHEMBL1509681 | 0.83 | CYP11B1 (1.00) | CYP11B1CYP11B2CYP19A1TBXAS1MEN1 | |
| Iodide SCHEMBL28192688 | 0.81 | CYP11B1 (0.97) | CYP11B1CYP11B2CYP19A1TBXAS1MEN1 | |
| Hydrochloric Acid SCHEMBL28135987 | 0.81 | CYP11B1 (0.97) | CYP11B1CYP11B2CYP19A1TBXAS1MEN1 | |
| SCHEMBL9414537 | 0.80 | CYP19A1 (0.56) | CYP11B1CYP11B2CYP19A1TBXAS1 | |
| SCHEMBL15173640 | 0.80 | CYP19A1 (0.56) | CYP11B1CYP11B2CYP19A1TBXAS1 | |
| SCHEMBL11607374 | 0.80 | ALDH1A1 (0.57) | CYP11B1CYP11B2CYP19A1TBXAS1LMNA | |
| SCHEMBL27311222 | 0.80 | CYP19A1 (0.56) | CYP11B1CYP11B2CYP19A1TBXAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0588858-B1 | IMIDAZO 2,1-b] 3]BENZAZEPINE DERIVATIVES, COMPOSITIONS AND METHOD OF USE | JANSSEN PHARMACEUTICA NV (BE) | 2003-09-17 | — | — | EP | disclosed |
| CN-1142360-A | A method for preparing a medical composition conpaining imidazo[2,1-b][3] benzo azepine dericvants | YUAN ANLING (CN) | 1997-02-12 | — | — | CN | disclosed |
| US-5468743-A | Imidazo[2,1-b]benzazepine derivatives, compositions and method of use | JANSSEN PHARMACEUTICA N.V. (BE) | 1995-11-21 | — | — | US | disclosed |
| EP-0588858-A1 | IMIDAZO 2,1-b] 3]BENZAZEPINE DERIVATIVES, COMPOSITIONS AND METHOD OF USE | JANSSEN PHARMACEUTICA N.V. (BE) | 1994-03-30 | — | — | EP | disclosed |
| WO-1992022551-A1 | IMIDAZO[2,1-b][3]BENZAZEPINE DERIVATIVES, COMPOSITIONS AND METHOD OF USE | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-12-23 | — | — | WO | disclosed |
| EP-0518435-A1 | Imidazo[2,1-b][3]benzazepine derivatives, compositions and method of use | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-12-16 | — | — | EP | disclosed |