Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | CFTR | P13569 | 1/20 | 0.43 |
| ▸ | GOPC | Q9HD26 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | APEX1 | P27695 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TNK2 | Q07912 | 5/20 | 0.39 |
| ▸ | RORC | P51449 | 4/20 | 0.38 |
| ▸ | PARG | Q86W56 | 1/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.37 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.37 |
| ▸ | CASR | P41180 | 3/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9998301 | 0.73 | MAPK1 (0.43) | CYP3A4LMNAMAPTAPEX1MAPK1 | |
| SCHEMBL9906168 | 0.71 | CASR (0.54) | CYP3A4TSHRCYP2C19MEN1KMT2A | |
| SCHEMBL9998378 | 0.71 | LMNA (0.41) | CYP3A4LMNAMAPTAPEX1MAPK1 | |
| SCHEMBL6991069 | 0.70 | PLAU (0.55) | CYP3A4LMNAMAPTAPEX1MAPK1 | |
| SCHEMBL15893211 | 0.70 | LMNA (0.56) | CYP3A4CYP2C19LMNAMAPTAPEX1 | |
| SCHEMBL19130234 | 0.70 | CASR (0.54) | CYP3A4TSHRCYP2C19MEN1KMT2A | |
| SCHEMBL17295892 | 0.70 | CASR (0.54) | CYP3A4TSHRCYP2C19MEN1KMT2A | |
| SCHEMBL9906175 | 0.69 | KMT2A (0.82) | CYP3A4TSHRLMNAMAPK1MEN1 | |
| SCHEMBL16144309 | 0.69 | KMT2A (0.82) | CYP3A4TSHRLMNAMAPK1MEN1 | |
| SCHEMBL4062666 | 0.69 | KMT2A (0.82) | CYP3A4TSHRLMNAMAPK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1023268-B1 | ISOQUINOLINES AS UROKINASE INHIBITORS | PFIZER LTD (GB) | 2003-05-21 | — | — | EP | disclosed |
| US-6248738-B1 | ANTIULCER AGENTS, ANGIOGENESIS INHIBITORS, ANTIMETASTASIS AGENTS, ANTITUMOR AGENTS | PFIZER INC. | 2001-06-19 | — | — | US | disclosed |
| EP-1023268-A1 | ISOQUINOLINES AS UROKINASE INHIBITORS | Pfizer Limited (GB) | 2000-08-02 | — | — | EP | disclosed |
| WO-1999020608-A1 | ISOQUINOLINES AS UROKINASE INHIBITORS | PFIZER LIMITED (GB) | 1999-04-29 | — | — | WO | disclosed |