Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 5/20 | 0.37 |
| ▸ | GRIN2A | Q12879 | 5/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 5/20 | 0.37 |
| ▸ | PRCP | P42785 | 3/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.37 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.37 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.37 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.37 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 9/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 9/20 | 0.34 |
| ▸ | CHRNB4 | P30926 | 8/20 | 0.34 |
| ▸ | CHRNA3 | P32297 | 8/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6999026 | 0.98 | OPRM1 (0.38) | GRIN1GRIN2AGRIN2BPRCPSIGMAR1 | |
| SCHEMBL6998209 | 0.84 | SIGMAR1 (0.39) | GRIN1GRIN2AGRIN2BPRCPSIGMAR1 | |
| Hydrochloric Acid SCHEMBL6994626 | 0.83 | OPRM1 (0.40) | GRIN1GRIN2AGRIN2BPRCPSIGMAR1 | |
| SCHEMBL6992209 | 0.81 | GRIN1 (0.37) | GRIN1GRIN2AGRIN2BPRCPSIGMAR1 | |
| Hydrochloric Acid SCHEMBL6991582 | 0.80 | OPRM1 (0.38) | GRIN1GRIN2AGRIN2BPRCPSIGMAR1 | |
| SCHEMBL6995444 | 0.75 | GRIN1 (0.37) | GRIN1GRIN2AGRIN2BPRCPSIGMAR1 | |
| Hydrochloric Acid SCHEMBL7001597 | 0.74 | OPRM1 (0.38) | GRIN1GRIN2AGRIN2BPRCPSIGMAR1 | |
| SCHEMBL6990087 | 0.72 | GRIN1 (0.45) | GRIN1GRIN2AGRIN2BPRCPSIGMAR1 | |
| SCHEMBL6992429 | 0.72 | GRIN1 (0.40) | GRIN1GRIN2AGRIN2BPRCPSIGMAR1 | |
| SCHEMBL6991802 | 0.72 | GRIN1 (0.43) | GRIN1GRIN2AGRIN2BPRCPSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0970083-B1 | 7a-HETEROCYCLE-SUBSTITUTED HEXAHYDRO-1H-PYRROLIZINE COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION | ABBOTT LAB (US) | 2003-04-16 | — | — | EP | claimed |
| EP-0970083-A1 | 7a-HETEROCYCLE-SUBSTITUTED HEXAHYDRO-1H-PYRROLIZINE COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION | Abbott Laboratories (US) | 2000-01-12 | — | — | EP | claimed |
| WO-1998037082-A1 | 7a-HETEROCYCLE-SUBSTITUTED HEXAHYDRO-1H-PYRROLIZINE COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION | ABBOTT LABORATORIES (US) | 1998-08-27 | — | — | WO | claimed |
| EP-0970083-B1 | 7a-HETEROCYCLE-SUBSTITUTED HEXAHYDRO-1H-PYRROLIZINE COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION | ABBOTT LAB (US) | 2003-04-16 | — | — | EP | disclosed |
| EP-0970083-A1 | 7a-HETEROCYCLE-SUBSTITUTED HEXAHYDRO-1H-PYRROLIZINE COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION | Abbott Laboratories (US) | 2000-01-12 | — | — | EP | disclosed |
| WO-1998037082-A1 | 7a-HETEROCYCLE-SUBSTITUTED HEXAHYDRO-1H-PYRROLIZINE COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION | ABBOTT LABORATORIES (US) | 1998-08-27 | — | — | WO | disclosed |
| US-5733912-A | NERVOUS SYSTEM DISORDERS IN NERVE CELLS | ABBOTT LABORATORIES (US) | 1998-03-31 | — | — | US | disclosed |