Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.35 |
| ▸ | PDE4A | P27815 | 3/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11193538 | 0.81 | ADORA2A (0.51) | MAPK1HTTTSHRADORA2BPDE4A | |
| SCHEMBL5403546 | 0.78 | PDE5A (0.45) | PDE5AMAPK1SMN1; SMN2POLBADORA2B | |
| SCHEMBL10991845 | 0.77 | PDE4A (0.51) | MAPK1SMN1; SMN2TSHRADORA2BPDE4A | |
| SCHEMBL675547 | 0.77 | PDE5A (0.43) | PDE5AADORA2BPDE4APDE4BPDE4C | |
| SCHEMBL5410997 | 0.77 | PDE1A (0.55) | PDE5AMAPK1KMT2ATSHRMEN1 | |
| SCHEMBL10988778 | 0.75 | ADORA2A (0.49) | MAPK1KMT2ASMN1; SMN2HTTTSHR | |
| SCHEMBL11185750 | 0.74 | PDE4A (0.37) | KMT2ASMN1; SMN2TSHRMEN1ADORA2B | |
| SCHEMBL4623469 | 0.72 | PDE4A (0.68) | PDE5AMAPK1TSHRADORA2BPDE4A | |
| SCHEMBL7458328 | 0.71 | ALDH1A1 (0.50) | MAPK1KMT2APOLBTSHRMEN1 | |
| SCHEMBL3665761 | 0.70 | HPGD (0.52) | KMT2ASMN1; SMN2HTTPOLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0975636-B1 | 1H-PYRAZOLO[3,4-D]PYRIMIDINE-4,6-DIONES AS T-CELL PROLIFERATION INHIBITORS | ASTRAZENECA AB (SE) | 2003-07-23 | — | — | EP | disclosed |
| US-6028074-A | FOR TREATING ALLOGRAFT REJECTION | ASTRA PHARMACEUTICALS, LTD. (GB) | 2000-02-22 | — | — | US | disclosed |
| EP-0975636-A1 | NOVEL COMPOUNDS | Astra Pharmaceuticals Limited (GB) | 2000-02-02 | — | — | EP | disclosed |
| WO-1998046606-A1 | NOVEL COMPOUNDS | ASTRA PHARMACEUTICALS LTD. (GB) | 1998-10-22 | — | — | WO | disclosed |