Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 12/20 | 0.45 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.45 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.45 |
| ▸ | PDE4A | P27815 | 9/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 9/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 9/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 9/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.41 |
| ▸ | PARG | Q86W56 | 2/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11193538 | 0.81 | ADORA2A (0.51) | PDE4APDE4BPDE4CPDE4DADORA1 | |
| SCHEMBL6992502 | 0.78 | PDE5A (0.45) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5410997 | 0.77 | PDE1A (0.55) | PDE5APDE3BPDE3APDE4APDE4B | |
| SCHEMBL675547 | 0.77 | PDE5A (0.43) | PDE5APDE3BPDE3APDE4APDE4B | |
| SCHEMBL10988778 | 0.75 | ADORA2A (0.49) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL5407428 | 0.72 | PDE5A (0.45) | PDE5APDE3BPDE3APDE4APDE4B | |
| SCHEMBL10991845 | 0.72 | PDE4A (0.51) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL11185750 | 0.71 | PDE4A (0.37) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL7458328 | 0.71 | ALDH1A1 (0.50) | ALDH1A1LMNAPOLBPARGMAPT | |
| SCHEMBL3665761 | 0.70 | HPGD (0.52) | ALDH1A1LMNAPOLBADORA2BMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7285558-B2 | Pyrazolo[3,4-d]pyrimidines inhibiting H. pylori infections | ASTRAZENECA AB (SE) | 2007-10-23 | — | — | US | disclosed |
| US-7285558-B2 | Pyrazolo[3,4-d]pyrimidines inhibiting H. pylori infections | ASTRAZENECA AB (SE) | 2007-10-23 | — | — | US | disclosed |
| US-7285558-B2 | Pyrazolo[3,4-d]pyrimidines inhibiting H. pylori infections | ASTRAZENECA AB (SE) | 2007-10-23 | — | — | US | disclosed |
| US-20040254183-A1 | Pyrazolo[3,4-d]pyrimidines inhibiting h. pylori infections | ASTRAZENECA AB (SE) | 2004-12-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040254183-A1 | Pyrazolo[3,4-d]pyrimidines inhibiting h. pylori infections | DPYD, HPGDS, PGC | PDE5A 933/4885PDE3B 420/4885PDE3A 271/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.