Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.48 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.44 |
| ▸ | CTSL | P07711 | 10/20 | 0.38 |
| ▸ | CTSS | P25774 | 8/20 | 0.38 |
| ▸ | CTSK | P43235 | 8/20 | 0.38 |
| ▸ | CTSB | P07858 | 7/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.38 |
| ▸ | PPARG | P37231 | 2/20 | 0.38 |
| ▸ | PPARA | Q07869 | 2/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | UGCG | Q16739 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6294856 | 0.94 | KLKB1 (0.43) | USP30KLKB1CTSLCTSSCTSK | |
| SCHEMBL6699086 | 0.94 | KLKB1 (0.43) | USP30KLKB1CTSLCTSSCTSK | |
| SCHEMBL6300222 | 0.90 | CTSL (0.39) | USP30CTSLCTSSCTSKCTSB | |
| SCHEMBL6701575 | 0.90 | TRPV1 (0.44) | USP30KLKB1CTSLCYP2D6CYP2C9 | |
| SCHEMBL6300527 | 0.89 | CTSL (0.38) | USP30CTSLCTSSCTSKCTSB | |
| SCHEMBL6295797 | 0.88 | KLKB1 (0.43) | USP30KLKB1CTSLCTSSCTSK | |
| SCHEMBL6696901 | 0.88 | USP30 (0.42) | USP30CTSLCTSSCTSKCTSB | |
| SCHEMBL6703701 | 0.87 | CTSL (0.44) | CTSLCTSSCTSKCTSB | |
| SCHEMBL6300636 | 0.86 | CTSL (0.41) | USP30CTSLCTSSCTSKCTSB | |
| SCHEMBL6294795 | 0.85 | CTSB (0.49) | USP30CTSLCTSSCTSKCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1358176-A2 | INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | Amura Therapeutics Limited (GB) | 2003-11-05 | — | — | EP | disclosed |
| WO-2002057246-A2 | INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | AMURA THERAPEUTICS LIMITED (GB) | 2002-07-25 | — | — | WO | disclosed |