Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 5/20 | 0.65 |
| ▸ | PLG | P00747 | 3/20 | 0.65 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.45 |
| ▸ | PLAT | P00750 | 2/20 | 0.45 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.40 |
| ▸ | BCR | P11274 | 1/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6994679 | 0.89 | PLAU (0.53) | PLAUPLGMAP4K4PLATABL1 | |
| SCHEMBL1536456 | 0.87 | PLAU (0.49) | PLAUPLGDYRK1AKMT2AALDH1A1 | |
| SCHEMBL7001317 | 0.87 | PLAU (0.67) | PLAUPLGMAP4K4DYRK1APDGFRB | |
| SCHEMBL6991093 | 0.85 | PLAU (0.49) | PLAUPLGMAP4K4DYRK1AABL1 | |
| SCHEMBL6998335 | 0.82 | PLAU (0.62) | PLAUPLGPLATNPC1RAB9A | |
| SCHEMBL1536440 | 0.80 | PLAU (0.46) | PLAUPLGDYRK1AKMT2AALDH1A1 | |
| SCHEMBL6437504 | 0.79 | PLAU (1.00) | PLAUPLGPLAT | |
| SCHEMBL6997008 | 0.78 | PLAU (0.50) | PLAUPLGPLATALDH1A1 | |
| SCHEMBL6437497 | 0.77 | PLAU (0.63) | PLAUPLGMAP4K4DYRK1APLAT | |
| SCHEMBL6997835 | 0.77 | PLAU (0.68) | PLAUPLGMAP4K4PLATPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1023268-B1 | ISOQUINOLINES AS UROKINASE INHIBITORS | PFIZER LTD (GB) | 2003-05-21 | — | — | EP | disclosed |
| US-6248738-B1 | ANTIULCER AGENTS, ANGIOGENESIS INHIBITORS, ANTIMETASTASIS AGENTS, ANTITUMOR AGENTS | PFIZER INC. | 2001-06-19 | — | — | US | disclosed |