Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 3/20 | 0.68 |
| ▸ | PLG | P00747 | 2/20 | 0.68 |
| ▸ | PLAT | P00750 | 1/20 | 0.68 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 8/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 8/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 8/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 8/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 8/20 | 0.48 |
| ▸ | TSHR | P16473 | 7/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | DHFR | P00374 | 1/20 | 0.47 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.46 |
| ▸ | FEN1 | P39748 | 1/20 | 0.46 |
| ▸ | CLK4 | Q9HAZ1 | 5/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27527937 | 0.86 | PLG (0.53) | PLAUPLGPLATMAP4K4LMNA | |
| SCHEMBL6997008 | 0.84 | PLAU (0.50) | PLAUPLGPLATALDH1A1 | |
| SCHEMBL6434201 | 0.81 | PLAU (1.00) | PLAUPLGPLATMAP4K4 | |
| SCHEMBL6434198 | 0.80 | PLAU (0.66) | PLAUPLGPLATMAP4K4LMNA | |
| SCHEMBL3738600 | 0.78 | MAP4K4 (0.71) | PLAUPLGPLATMAP4K4LMNA | |
| SCHEMBL6992595 | 0.77 | PLAU (0.65) | PLAUPLGPLATMAP4K4LMNA | |
| SCHEMBL7001317 | 0.76 | PLAU (0.67) | PLAUPLGMAP4K4LMNACYP1A2 | |
| SCHEMBL6994679 | 0.75 | PLAU (0.53) | PLAUPLGPLATMAP4K4CYP1A2 | |
| SCHEMBL27979076 | 0.75 | PTPRC (0.57) | PLAUPLGPLATMAP4K4LMNA | |
| SCHEMBL18970603 | 0.75 | MAP4K4 (0.60) | PLAUPLGPLATMAP4K4LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1023268-B1 | ISOQUINOLINES AS UROKINASE INHIBITORS | PFIZER LTD (GB) | 2003-05-21 | — | — | EP | disclosed |
| US-6248738-B1 | ANTIULCER AGENTS, ANGIOGENESIS INHIBITORS, ANTIMETASTASIS AGENTS, ANTITUMOR AGENTS | PFIZER INC. | 2001-06-19 | — | — | US | disclosed |