Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 7/20 | 0.50 |
| ▸ | PLG | P00747 | 4/20 | 0.50 |
| ▸ | PLAT | P00750 | 2/20 | 0.50 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.42 |
| ▸ | CACNG8 | Q8WXS5 | 1/20 | 0.42 |
| ▸ | CTSA | P10619 | 3/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.36 |
| ▸ | NQO2 | P16083 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6997835 | 0.84 | PLAU (0.68) | PLAUPLGPLATALDH1A1 | |
| SCHEMBL6993461 | 0.81 | PLAU (0.77) | PLAUPLGPLAT | |
| SCHEMBL7001317 | 0.80 | PLAU (0.67) | PLAUPLGALDH1A1MAPT | |
| SCHEMBL6993459 | 0.79 | PLAU (0.50) | PLAUPLGPLATGRIA1CACNG8 | |
| SCHEMBL6992595 | 0.78 | PLAU (0.65) | PLAUPLGPLATALDH1A1 | |
| SCHEMBL6994679 | 0.77 | PLAU (0.53) | PLAUPLGPLAT | |
| SCHEMBL1536456 | 0.73 | PLAU (0.49) | PLAUPLGALDH1A1POLBMAPT | |
| SCHEMBL6998335 | 0.72 | PLAU (0.62) | PLAUPLGPLATALDH1A1MAPT | |
| SCHEMBL27527937 | 0.71 | PLG (0.53) | PLAUPLGPLATALDH1A1L3MBTL1 | |
| SCHEMBL9909315 | 0.69 | HTR5A (0.50) | PLAUPLGPLATCTSAHSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1023268-B1 | ISOQUINOLINES AS UROKINASE INHIBITORS | PFIZER LTD (GB) | 2003-05-21 | — | — | EP | disclosed |
| US-6248738-B1 | ANTIULCER AGENTS, ANGIOGENESIS INHIBITORS, ANTIMETASTASIS AGENTS, ANTITUMOR AGENTS | PFIZER INC. | 2001-06-19 | — | — | US | disclosed |
| EP-1023268-A1 | ISOQUINOLINES AS UROKINASE INHIBITORS | Pfizer Limited (GB) | 2000-08-02 | — | — | EP | disclosed |
| WO-1999020608-A1 | ISOQUINOLINES AS UROKINASE INHIBITORS | PFIZER LIMITED (GB) | 1999-04-29 | — | — | WO | disclosed |