Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 2/20 | 0.58 |
| ▸ | KDR | P35968 | 12/20 | 0.49 |
| ▸ | PLK1 | P53350 | 8/20 | 0.49 |
| ▸ | CDK2 | P24941 | 5/20 | 0.45 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.45 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.45 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.45 |
| ▸ | AURKA | O14965 | 2/20 | 0.43 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.42 |
| ▸ | INSR | P06213 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7238138 | 0.99 | FYN (0.58) | FYNKDRPLK1CDK2CCNA2 | |
| SCHEMBL6997719 | 0.93 | FYN (0.58) | FYNKDRPLK1CDK2CCNA2 | |
| SCHEMBL7230541 | 0.90 | FYN (0.57) | FYNKDRPLK1CDK2CCNA2 | |
| SCHEMBL7000795 | 0.88 | FYN (0.56) | FYNKDRPLK1CDK2CCNA2 | |
| Hydrochloric Acid SCHEMBL7000614 | 0.85 | KDR (0.64) | FYNKDRPLK1CDK2CCNA2 | |
| Hydrochloric Acid SCHEMBL7002776 | 0.85 | FYN (0.66) | FYNKDRPLK1CDK2CCNA2 | |
| SCHEMBL7235872 | 0.84 | FYN (0.59) | FYNKDRPLK1INSR | |
| SCHEMBL7241107 | 0.83 | FYN (0.51) | FYNKDRPLK1CDK2CCNA2 | |
| Hydrochloric Acid SCHEMBL6992934 | 0.82 | FYN (0.54) | FYNKDRPLK1CDK2CCNA2 | |
| SCHEMBL7230249 | 0.82 | FYN (0.56) | FYNKDRPLK1CDK2CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0989985-B1 | FUSED POLYCYCLIC 2-AMINOPYRIMIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS | CELLTECH THERAPEUTICS LTD (GB) | 2003-11-05 | — | — | EP | disclosed |
| US-6133257-A | Fused polycyclic 2-aminopyrimidine derivatives | CELLTECH THERAPEUTICS LIMITED (GB) | 2000-10-17 | — | — | US | disclosed |
| EP-0989985-A1 | FUSED POLYCYCLIC 2-AMINOPYRIMIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS | CELLTECH THERAPEUTICS LIMITED (GB) | 2000-04-05 | — | — | EP | disclosed |
| WO-1998058926-A1 | FUSED POLYCYCLIC 2-AMINOPYRIMIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS | CELLTECH THERAPEUTICS LIMITED (GB) | 1998-12-30 | — | — | WO | disclosed |