Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 2/20 | 0.57 |
| ▸ | PLK1 | P53350 | 9/20 | 0.49 |
| ▸ | KDR | P35968 | 10/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.48 |
| ▸ | KIT | P10721 | 1/20 | 0.48 |
| ▸ | FLT3 | P36888 | 1/20 | 0.48 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.48 |
| ▸ | CDK2 | P24941 | 3/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.45 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.45 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.41 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.41 |
| ▸ | INSR | P06213 | 1/20 | 0.41 |
| ▸ | CSF1R | P07333 | 1/20 | 0.41 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.41 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.41 |
| ▸ | IGF1R | P08069 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7232727 | 0.90 | FYN (0.58) | FYNPLK1KDRINSRIGF1R | |
| SCHEMBL6992927 | 0.90 | FYN (0.58) | FYNPLK1KDRCDK2AURKA | |
| Hydrochloric Acid SCHEMBL7238138 | 0.89 | FYN (0.58) | FYNPLK1KDRCDK2AURKA | |
| SCHEMBL6997719 | 0.88 | FYN (0.58) | FYNPLK1KDRCDK2AURKA | |
| SCHEMBL7242766 | 0.84 | FYN (0.60) | FYNPLK1KDRINSRIGF1R | |
| Hydrochloric Acid SCHEMBL7002776 | 0.83 | FYN (0.66) | FYNPLK1KDRCDK2AURKA | |
| SCHEMBL7239298 | 0.82 | FYN (0.62) | FYNPLK1KDRPDGFRBPLK3 | |
| Hydrochloric Acid SCHEMBL7000614 | 0.82 | KDR (0.64) | FYNPLK1KDRCDK2CCNA2 | |
| SCHEMBL7241107 | 0.82 | FYN (0.51) | FYNPLK1KDRFGFR1CDK2 | |
| SCHEMBL7000795 | 0.81 | FYN (0.56) | FYNPLK1KDRCDK2AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6599908-B1 | Potent and selective inhibitors of the protein tyrosine kinases p56lck and p59fyn | CELLTECH R & D LIMITED (GB) | 2003-07-29 | — | — | US | disclosed |
| US-6057329-A | Fused polycyclic 2-aminopyrimidine derivatives | CELLTECH THERAPEUTICS LIMITED (GB) | 2000-05-02 | — | — | US | disclosed |