Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 2/20 | 0.56 |
| ▸ | KDR | P35968 | 12/20 | 0.51 |
| ▸ | PLK1 | P53350 | 10/20 | 0.51 |
| ▸ | INSR | P06213 | 1/20 | 0.45 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.44 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.44 |
| ▸ | IKBKB | O14920 | 1/20 | 0.44 |
| ▸ | IGF1R | P08069 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7000614 | 0.85 | KDR (0.64) | FYNKDRPLK1INSRCCNA2 | |
| Hydrochloric Acid SCHEMBL6992934 | 0.84 | FYN (0.54) | FYNKDRPLK1INSRCCNA2 | |
| SCHEMBL6997719 | 0.84 | FYN (0.58) | FYNKDRPLK1INSRCCNA2 | |
| Hydrochloric Acid SCHEMBL7231258 | 0.83 | FYN (0.54) | FYNKDRPLK1INSRCCNA2 | |
| SCHEMBL6992927 | 0.82 | FYN (0.58) | FYNKDRPLK1INSRCCNA2 | |
| SCHEMBL7000795 | 0.82 | FYN (0.56) | FYNKDRPLK1CCNA2CDK2 | |
| Hydrochloric Acid SCHEMBL7238138 | 0.81 | FYN (0.58) | FYNKDRPLK1INSRCCNA2 | |
| SCHEMBL7235315 | 0.81 | FYN (0.54) | FYNKDRPLK1CCNA2CDK2 | |
| SCHEMBL7231388 | 0.81 | FYN (0.61) | FYNKDRPLK1INSRCCNA2 | |
| SCHEMBL7241122 | 0.81 | FYN (0.65) | FYNKDRPLK1INSRIKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6599908-B1 | Potent and selective inhibitors of the protein tyrosine kinases p56lck and p59fyn | CELLTECH R & D LIMITED (GB) | 2003-07-29 | — | — | US | disclosed |
| US-6057329-A | Fused polycyclic 2-aminopyrimidine derivatives | CELLTECH THERAPEUTICS LIMITED (GB) | 2000-05-02 | — | — | US | disclosed |