Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 17/20 | 0.72 |
| ▸ | HTR2A | P28223 | 3/20 | 0.59 |
| ▸ | HTR6 | P50406 | 3/20 | 0.59 |
| ▸ | DRD2 | P14416 | 2/20 | 0.59 |
| ▸ | DRD1 | P21728 | 2/20 | 0.59 |
| ▸ | HTR2C | P28335 | 2/20 | 0.59 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.59 |
| ▸ | HTR1A | P08908 | 2/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4612355 | 0.84 | HTR7 (1.00) | HTR7HTR2AHTR6DRD2DRD1 | |
| SCHEMBL4612142 | 0.77 | HTR7 (1.00) | HTR7HTR2AHTR6DRD2DRD1 | |
| SCHEMBL8011291 | 0.76 | DRD2 (0.65) | HTR7HTR2ADRD2DRD1HTR1A | |
| SCHEMBL2149070 | 0.75 | HTR7 (0.59) | HTR7HTR2AHTR6DRD2DRD1 | |
| SCHEMBL6713388 | 0.75 | DRD2 (0.55) | HTR7HTR2ADRD2DRD1HTR1A | |
| SCHEMBL4612938 | 0.74 | HTR7 (1.00) | HTR7HTR2AHTR6DRD2DRD1 | |
| SCHEMBL8001978 | 0.74 | DRD2 (0.63) | HTR7HTR2ADRD2DRD1HTR1A | |
| SCHEMBL4613162 | 0.74 | HTR7 (1.00) | HTR7HTR2AHTR6DRD2DRD1 | |
| SCHEMBL4612207 | 0.73 | HTR7 (1.00) | HTR7HTR2AHTR6DRD2DRD1 | |
| SCHEMBL8001944 | 0.73 | DRD2 (0.65) | HTR7HTR2ADRD2DRD1HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6207677-B1 | ADMINISERING SIGMA RECEPTOR BINDING PIPERIDINE DERIVATIVE FOR TREATING ANXIETY, EPILEPSY, CONVULSION, MOVEMENT DISORDER, AMNESIA | H. LUNDBECK A/S (DK) | 2001-03-27 | — | — | US | claimed |
| EP-0859004-B1 | Piperidine derivatives having anxiolytic effect | LUNDBECK & CO AS H (DK) | 2003-05-02 | — | — | EP | disclosed |
| US-6207677-B1 | ADMINISERING SIGMA RECEPTOR BINDING PIPERIDINE DERIVATIVE FOR TREATING ANXIETY, EPILEPSY, CONVULSION, MOVEMENT DISORDER, AMNESIA | H. LUNDBECK A/S (DK) | 2001-03-27 | — | — | US | disclosed |
| US-6031099-A | Piperidine derivates having anxiolytic effect | H. LUNDBECK A/S (DK) | 2000-02-29 | — | — | US | disclosed |
| EP-0859004-A1 | Piperidine derivatives having anxiolytic effect | H. LUNDBECK A/S (DK) | 1998-08-19 | — | — | EP | disclosed |
| EP-0853085-A1 | Piperidine derivatives having anxiolytic effect | H. LUNDBECK A/S (DK) | 1998-07-15 | — | — | EP | disclosed |
| US-5665725-A | Piperidine derivatives having anxiolytic effect | Lundbeck, H. (DK) | 1997-09-09 | — | — | US | disclosed |
| EP-0518805-A1 | Piperidine derivatives | H. LUNDBECK A/S (DK) | 1992-12-16 | — | — | EP | disclosed |