SCHEMBL6993091

SCHEMBL6993091

COc1cc(NC(=O)c2ccccc2-c2ccccc2)ccc1C(=O)O

nearest known ligand 0.73

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTT P42858 4/20 0.73
GAA P10253 2/20 0.66
POLB P06746 1/20 0.66
KDM4E B2RXH2 2/20 0.65
TP53 P04637 1/20 0.59
L3MBTL1 Q9Y468 1/20 0.59
CHRNB2 P17787 1/20 0.58
CHRNB4 P30926 1/20 0.58
CHRNA3 P32297 1/20 0.58
CHRNA4 P43681 1/20 0.58
LMNA P02545 2/20 0.58
AVPR2 P30518 2/20 0.58
AVPR1A P37288 1/20 0.58
AVPR1B P47901 1/20 0.58
ALDH1A1 P00352 3/20 0.56
MAPT P10636 1/20 0.56
KMT2A Q03164 1/20 0.54
KCNK3 O14649 1/20 0.53
KCNK9 Q9NPC2 1/20 0.53
MTTP P55157 3/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7417220 0.99 HTT (0.71) HTTGAAPOLBKDM4ETP53
Water SCHEMBL7417216 0.97 HTT (0.70) HTTGAAPOLBKDM4ETP53
SCHEMBL6993922 0.92 HTT (0.73) HTTGAAPOLBKDM4ETP53
SCHEMBL6992682 0.86 HTT (0.55) HTTGAAPOLBKDM4ELMNA
SCHEMBL2595461 0.86 HTT (0.63) HTTGAAPOLBKDM4ELMNA
SCHEMBL3296193 0.83 MCHR1 (0.69) POLBKDM4ETP53LMNAALDH1A1
SCHEMBL23202424 0.82 KMT2A (0.64) HTTGAAPOLBKDM4ELMNA
SCHEMBL30452420 0.82 KMT2A (0.64) HTTGAAPOLBKDM4ELMNA
SCHEMBL1458777 0.80 CHRNB2 (0.63) HTTGAAPOLBKDM4ETP53
SCHEMBL5945595 0.80 TP53 (0.80) HTTGAAPOLBKDM4ETP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1021444-B1 3-CARBOXAMIDE DERIVATIVES OF 5H-PYRROLO[2,1-c][1,4]-BENZODIAZEPINES WYETH CORP (US) 2003-09-24 EP disclosed
EP-1021444-A1 3-CARBOXAMIDE DERIVATIVES OF 5H-PYRROLO[2,1-c][1,4]-BENZODIAZEPINES AMERICAN HOME PRODUCTS CORPORATION (US) 2000-07-26 EP disclosed
EP-0915876-A1 TRICYCLIC BENZAZEPINE VASOPRESSIN ANTAGONISTS American Cyanamid Company (US) 1999-05-19 EP disclosed
US-5880122-A TREATING DISEASES CHARACTERIZED BY EXCESS RENAL REABSORPTION OF WATER AMERICAN HOME PRODUCTS CORPORATION (US) 1999-03-09 US disclosed
WO-1997049708-A9 TRICYCLIC BENZAZEPINE VASOPRESSIN ANTAGONISTS 1998-05-22 WO disclosed
US-5753648-A THREATING DISEASES CAUSED BY RENAL REABSORPTION OF WATER AMERICAN CYANAMID COMPANY (US) 1998-05-19 US disclosed
WO-1998020011-A1 3-CARBOXAMIDE DERIVATIVES OF 5H-PYRROLO[2,1-c][1,4]-BENZODIAZEPINES AMERICAN HOME PRODUCTS CORPORATION (US) 1998-05-14 WO disclosed
WO-1997049707-A1 TRICYCLIC BENZAZEPINE VASOPRESSIN ANTAGONISTS AMERICAN CYANAMID COMPANY (US) 1997-12-31 WO disclosed
WO-1997049708-A1 TRICYCLIC BENZAZEPINE VASOPRESSIN ANTAGONISTS AMERICAN CYANAMID COMPANY (US) 1997-12-31 WO disclosed
US-5700796-A USEFUL FOR TREATING CONGESTIVE HEART FAILURE, DISEASE CONDITIONS WITH EXCESS RENAL WATER REABSORPTION AND CONDITIONS WITH INCREASED VASULAR RESISTANCE AND CORONARY VASOCONSTRICTION AMERICAN CYANAMID COMPANY (US) 1997-12-23 US disclosed