Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 1/20 | 0.55 |
| ▸ | GLS | O94925 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | MAOA | P21397 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | CASP3 | P42574 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.49 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.49 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29459546 | 1.00 | DRD3 (0.55) | DRD3GLSALDH1A1MAOAMAOB | |
| SCHEMBL5889451 | 0.89 | MAPT (0.60) | DRD3GLSALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL29459491 | 0.89 | MAPT (0.60) | DRD3GLSALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL5840903 | 0.87 | TDP1 (0.56) | DRD3ALDH1A1MAOBRAB9ASMN1; SMN2 | |
| SCHEMBL8688325 | 0.85 | TDP1 (0.58) | ALDH1A1MAOBMAPTTDP1L3MBTL1 | |
| SCHEMBL10061543 | 0.85 | TDP1 (0.58) | ALDH1A1MAOBMAPTTDP1L3MBTL1 | |
| SCHEMBL18410088 | 0.82 | HTR1A (0.62) | DRD3GLSALDH1A1MAOAMAOB | |
| SCHEMBL7349154 | 0.82 | GLS (0.57) | GLSRAB9ACASP3SMN1; SMN2NPC1 | |
| SCHEMBL11419367 | 0.80 | CES1 (0.71) | ALDH1A1MAOAMAOBMAPT | |
| SCHEMBL6699936 | 0.80 | GLS (0.71) | GLSRAB9ACASP3SMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-55147246-A | — | — | None | — | — | JP | disclosed |
| EP-4004002-B1 | MACROCYCLIC COMPOUNDS AS STING AGONISTS AND METHODS AND USES THEREOF | LUPIN LTD (IN) | 2024-07-10 | — | — | EP | disclosed |
| CN-114174303-B | Macrocyclic compounds as STING agonists and methods and uses thereof | 印度鲁宾有限公司 | 2024-06-25 | — | — | CN | disclosed |
| CN-114174303-A | Macrocyclic compounds as STING agonists, methods and uses thereof | 印度鲁宾有限公司 | 2022-03-11 | — | — | CN | disclosed |
| WO-2021014365-A1 | MACROCYCLIC COMPOUNDS AS STING AGONISTS AND METHODS AND USES THEREOF | LUPIN LIMITED (IN) | 2021-01-28 | — | — | WO | disclosed |
| EP-2753604-B1 | PDE10 MODULATORS | HOFFMANN LA ROCHE (CH) | 2015-08-19 | — | — | EP | disclosed |
| US-8772510-B2 | PDE10 modulators | HOFFMANN-LA ROCHE INC. (US) | 2014-07-08 | — | — | US | disclosed |
| CN-103781768-A | PDE10 modulators | HOFFMANN LA ROCHE | 2014-05-07 | — | — | CN | disclosed |
| EP-2574607-A1 | PDE10 modulators | F. Hoffmann-La Roche AG (CH) | 2013-04-03 | — | — | EP | disclosed |
| WO-2013034506-A1 | PDE10 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2013-03-14 | — | — | WO | disclosed |
| US-5834499-A | TREATING GASTROINTESTINAL DISORDERS | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1998-11-10 | — | — | US | disclosed |
| CN-1040210-C | Fused benzazepine derivative and pharmaceutical composition containing the same | YAMANOUCHI PHARMA CO LTD (JP) | 1998-10-14 | — | — | CN | disclosed |
| US-5723606-A | Condensed benzazepine derivative and pharmaceutical composition thereof | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1998-03-03 | — | — | US | disclosed |
| CN-1143364-A | 5-HT3 receptor agonist, novel thiazole derivative, and intermediate thereof | YAMANOUCHI PHARMA CO LTD (JP) | 1997-02-19 | — | — | CN | disclosed |
| EP-0749966-A1 | 5-HT 3 RECEPTOR AGONIST, NOVEL THIAZOLE DERIVATIVE, AND INTERMEDIATE THEREFOR | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1996-12-27 | — | — | EP | disclosed |
| CN-1127508-A | Fused benzazepine * derivatives and pharmaceutical compositions thereof | YAMANOUCHI PHARMA CO LTD (JP) | 1996-07-24 | — | — | CN | disclosed |
| EP-0709386-A1 | FUSED BENZAZEPINE DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1996-05-01 | — | — | EP | disclosed |
| EP-0074229-A1 | Triazole gastric anti-secretory agents | PFIZER INC. (US) | 1983-03-16 | — | — | EP | disclosed |
| JP-S55147246-A | PREPARATION OF ALPHA-CHLORO-BETA-ALANINE | MITSUI TOATSU CHEM INC | 1980-11-17 | — | — | JP | disclosed |
| US-3993437-A | Process for the dyeing of polyamide fibers with sulphur dyestuffs | CASSELLA FARBWERKE MAINKUR AKTIENGESELLSCHAFT (DT) | 1976-11-23 | — | — | US | disclosed |