Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 19/20 | 0.44 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.36 |
| ▸ | FBP1 | P09467 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6990256 | 0.92 | EGFR (0.46) | EGFRERBB2HPGDHTTGRM1 | |
| SCHEMBL6995684 | 0.92 | EGFR (0.48) | EGFR | |
| SCHEMBL6993350 | 0.81 | EGFR (0.43) | EGFRERBB2HPGDHTTGRM1 | |
| SCHEMBL6992624 | 0.81 | EGFR (0.43) | EGFRERBB2HPGDHTTGRM1 | |
| SCHEMBL8318338 | 0.81 | EGFR (0.51) | EGFRERBB2HPGDHTTGRM1 | |
| SCHEMBL6994181 | 0.78 | EGFR (0.58) | EGFRERBB2HPGDHTTGRM1 | |
| SCHEMBL8316782 | 0.76 | LMNA (0.50) | EGFRERBB2FBP1MAPT | |
| SCHEMBL8313726 | 0.75 | EGFR (0.59) | EGFRERBB2HTTMAPT | |
| SCHEMBL8317436 | 0.75 | EGFR (0.69) | EGFRERBB2 | |
| SCHEMBL6999541 | 0.74 | EGFR (0.52) | EGFRERBB2HPGDHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888351-B1 | PYRIMIDO 5,4-D]PYRIMIDINES, MEDICAMENTS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PRODUCTION | THOMAE GMBH DR K (DE) | 2003-10-15 | — | — | EP | disclosed |