Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 19/20 | 0.69 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.55 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6992120 | 0.87 | EGFR (0.70) | EGFRERBB2 | |
| SCHEMBL8314131 | 0.86 | EGFR (0.53) | EGFR | |
| SCHEMBL8313726 | 0.86 | EGFR (0.59) | EGFRMEN1ERBB2KMT2A | |
| SCHEMBL8320191 | 0.85 | EGFR (0.65) | EGFRERBB2 | |
| SCHEMBL8314069 | 0.84 | EGFR (0.57) | EGFRTNK2 | |
| SCHEMBL8312894 | 0.84 | EGFR (0.51) | EGFR | |
| SCHEMBL8317468 | 0.83 | EGFR (0.57) | EGFR | |
| SCHEMBL7000944 | 0.83 | EGFR (0.53) | EGFRERBB2MKNK1 | |
| SCHEMBL6994562 | 0.83 | EGFR (0.50) | EGFR | |
| SCHEMBL6997172 | 0.82 | EGFR (0.50) | EGFRTNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0779888-B1 | PYRIMIDO [5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | BOEHRINGER INGELHEIM PHARMA (DE) | 1999-04-28 | — | — | EP | disclosed |