Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | F2 | P00734 | 1/20 | 0.47 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.42 |
| ▸ | IDH1 | O75874 | 1/20 | 0.41 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | RXFP3 | Q9NSD7 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7491861 | 0.90 | MAPT (0.45) | SMN1; SMN2SIRT1MAPTMEN1KMT2A | |
| SCHEMBL19360455 | 0.89 | MET (0.48) | SMN1; SMN2F2MEN1KMT2ACREBBP | |
| SCHEMBL978722 | 0.87 | F2 (0.62) | SMN1; SMN2F2MEN1KMT2ALMNA | |
| SCHEMBL19360375 | 0.84 | KDM4E (0.46) | SMN1; SMN2F2LMNANPC1RAB9A | |
| SCHEMBL6987109 | 0.84 | F2 (0.54) | SMN1; SMN2F2SIRT1FFAR1ALDH1A1 | |
| SCHEMBL19360603 | 0.83 | MRGPRX4 (0.49) | F2MAPTMEN1KMT2ALMNA | |
| SCHEMBL7495434 | 0.81 | MTNR1A (0.49) | SMN1; SMN2F2MAPTLMNANPC1 | |
| SCHEMBL29465605 | 0.80 | SMN1; SMN2 (0.47) | SMN1; SMN2F2SIRT1MAPTLMNA | |
| SCHEMBL19360311 | 0.80 | SMN1; SMN2 (0.47) | SMN1; SMN2F2SIRT1MAPTLMNA | |
| SCHEMBL5794918 | 0.80 | MEN1 (0.49) | SMN1; SMN2MEN1KMT2ALMNANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1322646-A1 | 2-(1H-INDOL-3-YL)-2-OXO-ACETIC ACID AMIDES WITH ANTITUMOR ACTIVITY | Novuspharma S.p.A. (IT) | 2003-07-02 | — | — | EP | disclosed |
| WO-2002008225-A1 | 2-(1H-INDOL-3-YL)-2-OXO-ACETIC ACID AMIDES WITH ANTITUMOR ACTIVITY | NOVUSPHARMA S.P.A. (IT) | 2002-01-31 | — | — | WO | disclosed |