Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | GPR3 | P46089 | 1/20 | 0.45 |
| ▸ | NCF1 | P14598 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12503018 | 0.80 | MAPT (0.58) | MAPTMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL103601 | 0.77 | MAPT (0.62) | MAPTKDM4EALDH1A1CYP1A2GPR3 | |
| SCHEMBL29364974 | 0.77 | MAPT (0.62) | MAPTKDM4EALDH1A1CYP1A2GPR3 | |
| SCHEMBL26534307 | 0.77 | MAPT (0.47) | MAPTMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL15256359 | 0.77 | MAPT (0.70) | MAPTMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL14067142 | 0.76 | TDP1 (0.58) | MAPTMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL5722728 | 0.75 | MAPT (0.46) | MAPTMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL10894141 | 0.75 | KDM4E (0.46) | MAPTMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL12363914 | 0.75 | ALDH1A1 (0.62) | MAPTMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL11011451 | 0.75 | MAPT (0.59) | MAPTKDM4EALDH1A1CYP1A2GPR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012065057-A2 | PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS AND METHODS OF THEIR USE | EXELIXIS, INC. (US) | 2012-05-18 | — | — | WO | disclosed |