Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | GLA | P06280 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | HTR1A | P08908 | 9/20 | 0.51 |
| ▸ | ADRA1D | P25100 | 9/20 | 0.51 |
| ▸ | HTR1B | P28222 | 9/20 | 0.51 |
| ▸ | ADRA1A | P35348 | 9/20 | 0.51 |
| ▸ | ADRA1B | P35368 | 9/20 | 0.51 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6999670 | 0.89 | HTR1A (0.64) | KDM4EALDH1A1GLAGAAMAPT | |
| SCHEMBL7719577 | 0.82 | HTR1A (0.60) | LMNAHTR1AADRA1DHTR1BADRA1A | |
| SCHEMBL7722319 | 0.80 | HTR1A (0.58) | HTR1AADRA1DHTR1BADRA1AADRA1B | |
| SCHEMBL7720235 | 0.77 | HTR1A (0.78) | HTR1AADRA1DHTR1BADRA1AADRA1B | |
| SCHEMBL6997290 | 0.76 | HTR1A (0.81) | HTR1AADRA1DHTR1BADRA1AADRA1B | |
| SCHEMBL6992079 | 0.76 | HTR1A (0.59) | LMNAHTR1AADRA1DHTR1BADRA1A | |
| SCHEMBL7717801 | 0.74 | HTR1A (0.81) | HTR1AADRA1DHTR1BADRA1AADRA1B | |
| Hydrochloric Acid SCHEMBL7719545 | 0.74 | HTR1A (0.80) | HTR1AADRA1DHTR1BADRA1AADRA1B | |
| SCHEMBL7719498 | 0.74 | HTR1A (0.56) | MAPTHTR1AADRA1DHTR1BADRA1A | |
| SCHEMBL7715005 | 0.74 | HTR1A (0.56) | HTR1AADRA1DHTR1BADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0927184-B1 | 3-SUBSTITUTED PYRIDO 4',3':4,5]THIENO 2,3-D]PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE | ABBOTT GMBH & CO KG (DE) | 2003-10-22 | — | — | EP | disclosed |
| US-6387912-B1 | STROKE THERAPY | BASF AKTIENGESELLSCHAFT (DE) | 2002-05-14 | — | — | US | disclosed |
| US-6222034-B1 | AS SEROTININ RECEPTOR ANTAGONISTS; FOR THERAPY OF DEPRESSION, CENTRAL NERVOUS SYSTEM DISORDERS | BASF AKTIENGESELLSCHAFT (DE) | 2001-04-24 | — | — | US | disclosed |