Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 4/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | RHEB | Q15382 | 1/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.42 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.41 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6990848 | 0.88 | ALOX5 (0.53) | ALOX5 | |
| SCHEMBL6990729 | 0.81 | KDM4C (0.46) | NR4A2KMT2ASLC6A4SLC6A3MEN1 | |
| SCHEMBL16686988 | 0.80 | MTNR1A (0.49) | NR4A2ALOX5MTNR1AMTNR1BCDK5 | |
| SCHEMBL7427823 | 0.80 | MTNR1A (0.48) | NR4A2KMT2AMEN1RHEBMTNR1A | |
| SCHEMBL5002616 | 0.79 | SLC6A4 (0.52) | NR4A2ALOX5KMT2ASLC6A4SLC6A3 | |
| SCHEMBL7418911 | 0.78 | MTNR1A (0.51) | NR4A2KMT2AMEN1MTNR1AMTNR1B | |
| SCHEMBL6992585 | 0.78 | RHEB (0.53) | KMT2AMEN1RHEBMTNR1AMTNR1B | |
| SCHEMBL19644057 | 0.77 | NR4A2 (0.51) | NR4A2ALOX5CDK5CDK5R1 | |
| SCHEMBL6989875 | 0.76 | PRNP (0.46) | ALOX5RHEB | |
| SCHEMBL7422802 | 0.76 | ALOX5 (0.44) | NR4A2ALOX5MTNR1AMTNR1BCDK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1322646-A1 | 2-(1H-INDOL-3-YL)-2-OXO-ACETIC ACID AMIDES WITH ANTITUMOR ACTIVITY | Novuspharma S.p.A. (IT) | 2003-07-02 | — | — | EP | disclosed |
| EP-1244652-A1 | 2-(1H-INDOL-3-YL)-2-OXO-ACETAMIDES WITH ANTITUMOR ACTIVITY | Cell Therapeutics Europe S.R.L. (IT) | 2002-10-02 | — | — | EP | disclosed |
| WO-2002008225-A1 | 2-(1H-INDOL-3-YL)-2-OXO-ACETIC ACID AMIDES WITH ANTITUMOR ACTIVITY | NOVUSPHARMA S.P.A. (IT) | 2002-01-31 | — | — | WO | disclosed |
| WO-2001047916-A1 | 2-(1H-INDOL-3-YL)-2-OXO-ACETAMIDES WITH ANTITUMOR ACTIVITY | NOVUSPHARMA S.P.A. (IT) | 2001-07-05 | — | — | WO | disclosed |