Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 20/20 | 0.57 |
| ▸ | ADRA1D | P25100 | 20/20 | 0.57 |
| ▸ | HTR1B | P28222 | 20/20 | 0.57 |
| ▸ | ADRA1A | P35348 | 20/20 | 0.57 |
| ▸ | ADRA1B | P35368 | 20/20 | 0.57 |
| ▸ | DRD2 | P14416 | 2/20 | 0.55 |
| ▸ | HTR2A | P28223 | 2/20 | 0.55 |
| ▸ | HTR7 | P34969 | 2/20 | 0.55 |
| ▸ | DRD3 | P35462 | 2/20 | 0.55 |
| ▸ | HTR2C | P28335 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7672254 | 0.94 | HTR1A (0.58) | HTR1AADRA1DHTR1BADRA1AADRA1B | |
| SCHEMBL6996817 | 0.90 | HTR1A (0.55) | HTR1AADRA1DHTR1BADRA1AADRA1B | |
| SCHEMBL6998784 | 0.87 | HTR1A (0.77) | HTR1AADRA1DHTR1BADRA1AADRA1B | |
| SCHEMBL7001787 | 0.87 | HTR1A (0.75) | HTR1AADRA1DHTR1BADRA1AADRA1B | |
| SCHEMBL6997759 | 0.87 | HTR1A (0.75) | HTR1AADRA1DHTR1BADRA1AADRA1B | |
| SCHEMBL6989359 | 0.86 | HTR1A (0.75) | HTR1AADRA1DHTR1BADRA1AADRA1B | |
| Hydrochloric Acid SCHEMBL7718451 | 0.86 | HTR1A (0.74) | HTR1AADRA1DHTR1BADRA1AADRA1B | |
| Hydrochloric Acid SCHEMBL7720215 | 0.86 | HTR1A (0.74) | HTR1AADRA1DHTR1BADRA1AADRA1B | |
| SCHEMBL6999663 | 0.85 | HTR1A (0.77) | HTR1AADRA1DHTR1BADRA1AADRA1B | |
| SCHEMBL6992679 | 0.85 | HTR1A (0.49) | HTR1AADRA1DHTR1BADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1023296-B1 | 3-SUBSTITUTED PYRIDO 3',4':4,5] THIENO 2,3-D] PYRIMIDINE DERIVATIVES, AND PRODUCTION AND USE OF THE SAME | ABBOTT GMBH & CO KG (DE) | 2003-12-17 | — | — | EP | disclosed |
| US-6387912-B1 | STROKE THERAPY | BASF AKTIENGESELLSCHAFT (DE) | 2002-05-14 | — | — | US | disclosed |
| US-6159981-A | 3-substituted pyrido [3',4':4,5] Thieno [2,3-d] pyrimidine derivatives, and production and use of the same | BASF AKTIENGESELLSCHAFT (DE) | 2000-12-12 | — | — | US | disclosed |