Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 14/20 | 0.54 |
| ▸ | ERBB2 | P04626 | 12/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.45 |
| ▸ | BCL6 | P41182 | 1/20 | 0.44 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.43 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6994603 | 1.00 | EGFR (0.54) | EGFRERBB2HPGDHTTIRAK4 | |
| SCHEMBL6999329 | 0.90 | EGFR (0.55) | EGFRERBB2HPGDHTTIRAK4 | |
| SCHEMBL6999324 | 0.90 | EGFR (0.55) | EGFRERBB2HPGDHTTIRAK4 | |
| SCHEMBL6992378 | 0.88 | EGFR (0.48) | EGFRERBB2HPGDHTTIRAK4 | |
| SCHEMBL6992382 | 0.88 | EGFR (0.48) | EGFRERBB2HPGDHTTIRAK4 | |
| SCHEMBL8314462 | 0.86 | EGFR (0.63) | EGFRERBB2HPGDHTTIRAK4 | |
| SCHEMBL8314464 | 0.86 | EGFR (0.63) | EGFRERBB2HPGDHTTIRAK4 | |
| SCHEMBL3473824 | 0.83 | EGFR (0.76) | EGFRERBB2HPGDHTTIRAK4 | |
| SCHEMBL6989676 | 0.83 | EGFR (0.76) | EGFRERBB2HPGDHTTIRAK4 | |
| SCHEMBL8316360 | 0.81 | EGFR (0.57) | EGFRERBB2HPGDHTTIRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888351-B1 | PYRIMIDO 5,4-D]PYRIMIDINES, MEDICAMENTS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PRODUCTION | THOMAE GMBH DR K (DE) | 2003-10-15 | — | — | EP | disclosed |
| EP-0888351-A1 | PYRIMIDO 5,4-D]PYRIMIDINES, MEDICAMENTS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PRODUCTION | Dr. Karl Thomae GmbH (DE) | 1999-01-07 | — | — | EP | disclosed |
| WO-1997032880-A1 | PYRIMIDO[5,4-D]PYRIMIDINES, MEDICAMENTS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PRODUCTION | DR. KARL THOMAE GMBH (DE) | 1997-09-12 | — | — | WO | disclosed |