Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 9/20 | 0.55 |
| ▸ | ERBB2 | P04626 | 7/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | ERBB3 | P21860 | 6/20 | 0.49 |
| ▸ | ERBB4 | Q15303 | 6/20 | 0.49 |
| ▸ | IRAK4 | Q9NWZ3 | 5/20 | 0.46 |
| ▸ | BCL6 | P41182 | 2/20 | 0.44 |
| ▸ | CAMK2D | Q13557 | 2/20 | 0.43 |
| ▸ | BRAF | P15056 | 1/20 | 0.43 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6999324 | 1.00 | EGFR (0.55) | EGFRERBB2HPGDHTTERBB3 | |
| SCHEMBL6994597 | 0.90 | EGFR (0.54) | EGFRERBB2HPGDHTTIRAK4 | |
| SCHEMBL6994603 | 0.90 | EGFR (0.54) | EGFRERBB2HPGDHTTIRAK4 | |
| SCHEMBL8314462 | 0.86 | EGFR (0.63) | EGFRERBB2HPGDHTTIRAK4 | |
| SCHEMBL8314464 | 0.86 | EGFR (0.63) | EGFRERBB2HPGDHTTIRAK4 | |
| SCHEMBL3473824 | 0.84 | EGFR (0.76) | EGFRERBB2HPGDHTTIRAK4 | |
| SCHEMBL6989676 | 0.84 | EGFR (0.76) | EGFRERBB2HPGDHTTIRAK4 | |
| SCHEMBL8316363 | 0.82 | EGFR (0.57) | EGFRERBB2HPGDHTTIRAK4 | |
| SCHEMBL8316360 | 0.82 | EGFR (0.57) | EGFRERBB2HPGDHTTIRAK4 | |
| SCHEMBL6992378 | 0.80 | EGFR (0.48) | EGFRERBB2HPGDHTTERBB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888351-B1 | PYRIMIDO 5,4-D]PYRIMIDINES, MEDICAMENTS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PRODUCTION | THOMAE GMBH DR K (DE) | 2003-10-15 | — | — | EP | disclosed |