Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.34 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.33 |
| ▸ | RELA | Q04206 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | CASP3 | P42574 | 1/20 | 0.33 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6994616 | 0.74 | SIGMAR1 (0.46) | SIGMAR1KDM4EALDH1A1HTTGLA | |
| SCHEMBL27548530 | 0.64 | SIGMAR1 (0.45) | SIGMAR1MAPT | |
| SCHEMBL27484472 | 0.64 | SIGMAR1 (0.45) | SIGMAR1MAPT | |
| SCHEMBL5890646 | 0.63 | KDM4E (0.52) | KDM4ELMNARXFP1ALDH1A1HTT | |
| SCHEMBL31087243 | 0.63 | KDM4E (0.52) | KDM4ELMNARXFP1ALDH1A1HTT | |
| SCHEMBL6428849 | 0.63 | SMN1; SMN2 (0.49) | SIGMAR1LMNAALDH1A1HTTGAA | |
| SCHEMBL24042759 | 0.62 | KDM4E (0.44) | KDM4ELMNARXFP1ALDH1A1HTT | |
| SCHEMBL19240125 | 0.62 | KDM4E (0.41) | KDM4ELMNARXFP1ALDH1A1HTT | |
| SCHEMBL28420767 | 0.57 | NPSR1 (0.37) | KDM4ELMNAALDH1A1HTTHPGD | |
| SCHEMBL28421057 | 0.57 | PDK2 (0.38) | KDM4EALDH1A1HTTGAARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1109799-B1 | 4,5-DIARYL-3(2H)-FURANONE DERIVATIVES AS CYCLOOXYGENASE-2 INHIBITORS | PACIFIC CORP (KR) | 2003-12-17 | — | — | EP | disclosed |
| US-6492416-B1 | TREATING INFLAMMATION AND ASSOCIATED DISORDERS | PACIFIC CORPORATION (KR) | 2002-12-10 | — | — | US | disclosed |