Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 8/20 | 0.63 |
| ▸ | PLK1 | P53350 | 6/20 | 0.63 |
| ▸ | IKBKB | O14920 | 2/20 | 0.62 |
| ▸ | FYN | P06241 | 1/20 | 0.61 |
| ▸ | CDK2 | P24941 | 2/20 | 0.53 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.53 |
| ▸ | CDK1 | P06493 | 1/20 | 0.53 |
| ▸ | CDK4 | P11802 | 1/20 | 0.53 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.53 |
| ▸ | CCND1 | P24385 | 1/20 | 0.53 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.53 |
| ▸ | CDK7 | P50613 | 1/20 | 0.53 |
| ▸ | CDK9 | P50750 | 1/20 | 0.53 |
| ▸ | CCNH | P51946 | 1/20 | 0.53 |
| ▸ | AURKA | O14965 | 3/20 | 0.52 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.51 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.51 |
| ▸ | EGFR | P00533 | 1/20 | 0.51 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7249337 | 0.89 | IKBKB (0.62) | KDRPLK1IKBKBFYNCDK2 | |
| SCHEMBL6999967 | 0.88 | KDR (0.65) | KDRPLK1IKBKBFYNCDK2 | |
| SCHEMBL6992464 | 0.87 | KDR (0.65) | KDRPLK1IKBKBFYNCA12 | |
| SCHEMBL6998752 | 0.87 | IKBKB (0.58) | KDRPLK1IKBKBFYNCDK4 | |
| Hydrochloric Acid SCHEMBL7240389 | 0.86 | IKBKB (0.60) | KDRPLK1IKBKBFYNCDK2 | |
| SCHEMBL7003524 | 0.86 | FYN (0.60) | KDRPLK1IKBKBFYNEGFR | |
| Hydrochloric Acid SCHEMBL6991972 | 0.86 | FYN (0.68) | KDRPLK1IKBKBFYNCDK2 | |
| SCHEMBL17560321 | 0.85 | KDR (0.64) | KDRPLK1IKBKBFYNCDK2 | |
| SCHEMBL3522231 | 0.85 | IKBKB (0.86) | KDRPLK1IKBKBFYNCA12 | |
| SCHEMBL7232580 | 0.84 | KDR (0.63) | KDRPLK1IKBKBFYNAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0989985-B1 | FUSED POLYCYCLIC 2-AMINOPYRIMIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS | CELLTECH THERAPEUTICS LTD (GB) | 2003-11-05 | — | — | EP | disclosed |
| US-6133257-A | Fused polycyclic 2-aminopyrimidine derivatives | CELLTECH THERAPEUTICS LIMITED (GB) | 2000-10-17 | — | — | US | disclosed |
| EP-0989985-A1 | FUSED POLYCYCLIC 2-AMINOPYRIMIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS | CELLTECH THERAPEUTICS LIMITED (GB) | 2000-04-05 | — | — | EP | disclosed |
| WO-1998058926-A1 | FUSED POLYCYCLIC 2-AMINOPYRIMIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS | CELLTECH THERAPEUTICS LIMITED (GB) | 1998-12-30 | — | — | WO | disclosed |