Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 10/20 | 0.65 |
| ▸ | PLK1 | P53350 | 7/20 | 0.65 |
| ▸ | FYN | P06241 | 1/20 | 0.58 |
| ▸ | CDK2 | P24941 | 3/20 | 0.57 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.57 |
| ▸ | CDK1 | P06493 | 1/20 | 0.57 |
| ▸ | CDK4 | P11802 | 1/20 | 0.57 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.57 |
| ▸ | CCND1 | P24385 | 1/20 | 0.57 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.57 |
| ▸ | CDK7 | P50613 | 1/20 | 0.57 |
| ▸ | CDK9 | P50750 | 1/20 | 0.57 |
| ▸ | CCNH | P51946 | 1/20 | 0.57 |
| ▸ | IKBKB | O14920 | 1/20 | 0.54 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.53 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.53 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.53 |
| ▸ | AURKA | O14965 | 2/20 | 0.52 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17560321 | 0.91 | KDR (0.64) | KDRPLK1FYNCDK2CDK1 | |
| SCHEMBL6994864 | 0.88 | KDR (0.63) | KDRPLK1FYNCDK2CCNT1 | |
| SCHEMBL17560312 | 0.88 | CDK2 (0.61) | KDRPLK1CDK2CCNT1CDK1 | |
| SCHEMBL7238444 | 0.87 | FYN (0.58) | KDRPLK1FYNCDK2IKBKB | |
| SCHEMBL7241504 | 0.87 | FYN (0.58) | KDRPLK1FYNCDK2IKBKB | |
| SCHEMBL6992464 | 0.84 | KDR (0.65) | KDRPLK1FYNIKBKBKDM4E | |
| SCHEMBL6998752 | 0.84 | IKBKB (0.58) | KDRPLK1FYNCDK4CCND1 | |
| Hydrochloric Acid SCHEMBL7000614 | 0.84 | KDR (0.64) | KDRPLK1FYNCDK2CCNT1 | |
| SCHEMBL7230962 | 0.84 | KDR (0.56) | KDRPLK1FYNCDK2CDK1 | |
| SCHEMBL7241137 | 0.84 | KDR (0.72) | KDRPLK1CDK2CCNT1CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0989985-B1 | FUSED POLYCYCLIC 2-AMINOPYRIMIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS | CELLTECH THERAPEUTICS LTD (GB) | 2003-11-05 | — | — | EP | disclosed |
| US-6599908-B1 | Potent and selective inhibitors of the protein tyrosine kinases p56lck and p59fyn | CELLTECH R & D LIMITED (GB) | 2003-07-29 | — | — | US | disclosed |
| US-6133257-A | Fused polycyclic 2-aminopyrimidine derivatives | CELLTECH THERAPEUTICS LIMITED (GB) | 2000-10-17 | — | — | US | disclosed |
| US-6057329-A | Fused polycyclic 2-aminopyrimidine derivatives | CELLTECH THERAPEUTICS LIMITED (GB) | 2000-05-02 | — | — | US | disclosed |
| EP-0989985-A1 | FUSED POLYCYCLIC 2-AMINOPYRIMIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS | CELLTECH THERAPEUTICS LIMITED (GB) | 2000-04-05 | — | — | EP | disclosed |
| WO-1998058926-A1 | FUSED POLYCYCLIC 2-AMINOPYRIMIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS | CELLTECH THERAPEUTICS LIMITED (GB) | 1998-12-30 | — | — | WO | disclosed |