Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 2/20 | 0.58 |
| ▸ | FYN | P06241 | 2/20 | 0.57 |
| ▸ | KDR | P35968 | 12/20 | 0.55 |
| ▸ | PLK1 | P53350 | 6/20 | 0.55 |
| ▸ | INSR | P06213 | 1/20 | 0.48 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | CDK4 | P11802 | 1/20 | 0.46 |
| ▸ | CCND1 | P24385 | 1/20 | 0.46 |
| ▸ | CCND2 | P30279 | 1/20 | 0.46 |
| ▸ | CCND3 | P30281 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6992464 | 0.92 | KDR (0.65) | IKBKBFYNKDRPLK1INSR | |
| SCHEMBL6997904 | 0.89 | FYN (0.61) | IKBKBFYNKDRPLK1INSR | |
| SCHEMBL17560349 | 0.88 | IKBKB (0.59) | IKBKBFYNKDRPLK1CA12 | |
| SCHEMBL6994864 | 0.87 | KDR (0.63) | IKBKBFYNKDRPLK1KDM4E | |
| SCHEMBL7237418 | 0.86 | FYN (0.65) | IKBKBFYNKDRPLK1PTK2 | |
| Hydrochloric Acid SCHEMBL7240228 | 0.84 | FYN (0.65) | IKBKBFYNKDRPLK1INSR | |
| SCHEMBL6999967 | 0.84 | KDR (0.65) | IKBKBFYNKDRPLK1KDM4E | |
| SCHEMBL17560321 | 0.84 | KDR (0.64) | IKBKBFYNKDRPLK1KDM4E | |
| SCHEMBL7249337 | 0.83 | IKBKB (0.62) | IKBKBFYNKDRPLK1INSR | |
| Hydrochloric Acid SCHEMBL6991972 | 0.82 | FYN (0.68) | IKBKBFYNKDRPLK1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0989985-B1 | FUSED POLYCYCLIC 2-AMINOPYRIMIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS | CELLTECH THERAPEUTICS LTD (GB) | 2003-11-05 | — | — | EP | disclosed |
| US-6133257-A | Fused polycyclic 2-aminopyrimidine derivatives | CELLTECH THERAPEUTICS LIMITED (GB) | 2000-10-17 | — | — | US | disclosed |
| EP-0989985-A1 | FUSED POLYCYCLIC 2-AMINOPYRIMIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS | CELLTECH THERAPEUTICS LIMITED (GB) | 2000-04-05 | — | — | EP | disclosed |
| WO-1998058926-A1 | FUSED POLYCYCLIC 2-AMINOPYRIMIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS | CELLTECH THERAPEUTICS LIMITED (GB) | 1998-12-30 | — | — | WO | disclosed |